PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Gch1 Gch1 9685352 biogrid,i2d exp, ortho G G G G Gch1 Gchfr 15448133,9685352,9092499,11818540 biogrid,i2d,intact exp, ortho G G G G Gch1 Rab26 ortho Gch1 Ywhaz ortho G G G G Dnajb1_predicted Gch1 ortho G G G G Rgs19 Gch1 ortho G Gch1 Ppm1b ortho G G G G Gch1 Kpnb1 ortho G G G G Sh3gl2 Gch1 ortho Protein Ppp2r5c Gch1 ortho G G G G Gch1 Mapk12 ortho G G G G Gch1 Uba1 ortho G G G G LOC681996 protein, Protein Ahsa1, RCG20659, isoform CRA_b Gch1 ortho G G G G Gch1 Cdc37 ortho G G G G Protein Calml5 Gch1 ortho G G G Gch1 Prkacb ortho Gch1 Pacsin3 ortho G G G G Gch1 Camkk1 ortho G G G Mpped1_predicted Gch1 ortho Csnk2a1 Gch1 ortho Gch1 Kpna5 ortho Protein Ipo5 Gch1 ortho G G G G Prkar2b Gch1 ortho G G G Gch1 G protein-coupled receptor kinase interacting ArfGAP 2, Protein Git2 ortho G G G Gch1 Ggps1 ortho Gch1 Rph3a ortho Gch1 Cnrip1 ortho G G G G Gch1 Csnk2b ortho G G G G Gch1 Csnk1g1 ortho G Protein Cct7, RCG55994, isoform CRA_c Gch1 ortho G G G G Protein Atl2 Gch1 ortho G G G G Gch1 Mapk10 ortho Gch1 Ntmt1 ortho G G G G Atp1b1 Gch1 ortho G G G G Gch1 Map2k4 ortho Gch1 Fut8 ortho G G G G Fdps Gch1 ortho G G G G Gch1 Hspa8 ortho Gch1 Map2k5 ortho G G G G Gch1 Ubc ortho Gch1 Eif2b2 ortho G G G Prkar2a Gch1 ortho G G G G Hspa4 Gch1 ortho G G G G Gch1 Protein Riok2, RIO kinase 2 (Yeast), RIO kinase 2 (Yeast), isoform CRA_b ortho Th Gch1 ortho G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 15448133 - X 2 P22288 P22288 - 15448133 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 15448133 - X 2 P22288 P22288 - 15448133 - X 2 P22288 P22288 - 11818540 - X 2 P22288 P22288 - 11818540 - X 2 P70552 P22288 - 11818540 - X 2 P70552 P22288 - 11818540 - X 2 P70552 P22288 - 15448133 - X 2 P70552 P22288 - 15448133 - X 2 P70552 P22288 - 11818540 - X 2 P70552 P22288 - 11818540 - X 2 P22288 P22288 pull down 9685352 direct interaction X 2 P70552 P22288 enzymatic study 9092499 direct interaction X 2 P70552 P22288 enzymatic study 9685352 direct interaction X 2 P70552 P22288 x-ray crystallography 11818540 direct interaction X 2 P70552 P22288 x-ray crystallography 11818540 direct interaction X 2 P70552 P22288 x-ray crystallography 15448133 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Gch1 Gchfr MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0096(pull down) 11818540,15448133,9092499,9685352 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(intact)|(biogrid) UniProt_180958|BIOGRID_337034|UniProt_181135|UniProt_181136|BIOGRID_334564 neutral component|bait|neutral component|neutral component|prey neutral component|prey|neutral component|neutral component|bait

PPI - HINT Gene A Gene B PMID Method Quality GCH1 GCH1 15448133,11818540 0114,0114 LC GCH1 GCHFR 15448133,9092499,9685352,11818540 0114,0415,0415,0114 LC GCH1 GCH1 9685352 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P70552 P22288 GCHFR GCH1 0.843 9685352,15448133,9092499,11818540 P22288 P22288 GCH1 GCH1 0.332 9685352