PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Traf4_predicted Sqstm1 16246731 biogrid exp G G G G G G G G Traf4_predicted Ube2l3_predicted 16246731 biogrid exp G G G G G G G G Traf4_predicted Tgfb1i1 ortho G G G G G G G G Traf4_predicted Psmc3 ortho G G G G G G G G Traf4_predicted Hip1r ortho G G G G G G G G Traf4_predicted Maged1 ortho G G G G G G G G Traf4_predicted RGD1563179_predicted ortho Traf4_predicted RGD1562269_predicted ortho G G Traf4_predicted Protein Smurf1, RCG42768 ortho G G G G G G G G Traf4_predicted Cblc ortho Traf4_predicted Krt31 ortho Traf4_predicted Protein Dtx3 ortho G G G G G G G G Rnf135 Traf4_predicted ortho G G G G G G G G Traf4_predicted Arnt2 ortho G G G G G G Traf4_predicted Lymphotoxin B receptor, Lymphotoxin beta receptor (TNFR superfamily, member 3), Protein Ltbr ortho G G G G G G G G Traf4_predicted Krt40 ortho Traf4_predicted Spdl1 ortho Traf4_predicted Protein Cbl ortho Traf4_predicted Fhl2 ortho G G G G G G G Traf4_predicted Fam214b ortho G G G G G G G G Traf4_predicted Protein Spop, Speckle-type POZ protein, isoform CRA_a, Spop protein ortho G G G G G G G G Traf4_predicted Card15_predicted ortho Traf4_predicted Protein Ripk2, RCG54865 ortho Traf4_predicted Prmt5_predicted ortho G G G G G G G G Traf4_predicted Rps6kb1 ortho G Traf4_predicted Chuk_predicted ortho G G G G G G G G Traf4_predicted Homez ortho Traf4_predicted Rpl14 ortho G G G G G G G G Traf4_predicted Map3k7 ortho Traf4_predicted Myh9 ortho G G G G G G G G Traf4_predicted Kinesin-like protein ortho G Traf4_predicted Sumo1 ortho G G G G G G G G Traf4_predicted Gp1bb ortho Traf4_predicted Urkl1_predicted ortho Traf4_predicted Tyrosine-protein kinase ortho G G G G Ncf2 Traf4_predicted ortho Traf4_predicted Chromosome 6 open reading frame 4, isoform CRA_a, Protein Traf3ip2, Traf3 interacting protein 2 ortho G G G Banp_predicted Traf4_predicted ortho Traf4_predicted Exoc7 ortho Traf4_predicted Traf6 ortho Traf4_predicted Tnfrsf4 ortho G G Traf4_predicted Ngfr ortho Traf4_predicted Protein Npas2 ortho Traf4_predicted Cchcr1 ortho Traf4_predicted RGD1563127_predicted ortho G G G G G G G G Traf4_predicted Protein Tbc1d8 ortho Traf4_predicted Bckdk ortho G G G G G G G Traf4_predicted Trim37 ortho G G G G G G G G Traf4_predicted Irak1_predicted ortho G G G G G G G G Traf4_predicted Kdm1a ortho G G G G G G G G Traf4_predicted Alkbh4_predicted ortho Traf4_predicted Traf2_predicted ortho Traf4_predicted Protein LOC100911132 ortho Traf4_predicted Isyna1 ortho G G G G G G Traf4_predicted Gprasp1 ortho G G G G G G G G Traf4_predicted Ube2i ortho G G G G G G G G Traf4_predicted Traf4_predicted ortho G G G G G G G G Traf4_predicted Bysl ortho G G G G G G G G Traf4_predicted Gorasp2 ortho G G G G G G G G Traf4_predicted Map3k4_predicted ortho Traf4_predicted Ncf1 ortho G Traf4_predicted Tgfbr2 ortho Traf4_predicted Actn1 ortho G G G G G G G G Traf4_predicted Protein Tbc1d7 ortho G G G G G G G Traf4_predicted Plscr1 ortho G G Traf4_predicted LOC497876 ortho G G G G G G G G Traf4_predicted Ptk2b ortho G G Traf4_predicted Sorbs2 ortho G G G G G G G G Traf4_predicted Pde4dip ortho G G G G G G G G Traf4_predicted CD40 molecule, TNF receptor superfamily member 5, Protein Cd40, Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a ortho Traf4_predicted Protein Lipt1, RCG22417 ortho Traf4_predicted Pcgf4_predicted ortho Traf4_predicted Usp15 ortho G G G Traf4_predicted Rnf114 ortho G G G G G G G G Traf4_predicted E3 ubiquitin-protein ligase ortho G G G G Traf4_predicted Protein Tnfrsf9, Similar to T-cell antigen 4-1BB-mouse, isoform CRA_a, Tumor necrosis factor receptor superfamily, member 9 ortho Traf4_predicted Tarbp2 ortho G G G G G G G G Traf4_predicted Protein Fbxl18 ortho Traf4_predicted Ubl4a ortho G G G G G G G G Traf4_predicted Tgfbr1 ortho G G G G G G G G Traf4_predicted Usp7 ortho G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Traf4 Ube2l3 MI:0415(enzymatic study) 16246731 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334627 bait prey Sqstm1 Traf4 MI:0415(enzymatic study) 16246731 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334628 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TRAF4 UBE2L3 16246731 0004 LC TRAF4 SQSTM1 16246731 0004 LC