PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Scnn1g Tsg101 14556380 biogrid exp G G Slc2a4 Tsg101 16396496 intact exp G G G Tsg101 Aatf i2d exp, ortho G G G G G G G G Ntrk1 Tsg101 ortho LOC690374 Tsg101 ortho G G G G G G G G Tsg101 Orc1 ortho RGD1561605_predicted Tsg101 ortho Nono Tsg101 ortho G G G G G G G G Stam2 Tsg101 ortho Tsg101 Bag6 ortho G G G G G G Fdps Tsg101 ortho G G G G G G G G Tsg101 Hgs ortho G G G G G G G G Gap junction protein Tsg101 ortho G G G G Gga3_predicted Tsg101 ortho G G G G G G G Katnal1 Tsg101 ortho Litaf Tsg101 ortho G G G G G G G G Asparagine-linked glycosylation 2 homolog (Yeast, alpha-1,3-mannosyltransferase), isoform CRA_a, Protein Alg2 Tsg101 ortho G G G G G G G G Dctn2 Tsg101 ortho G G G G G G G G Thrb Tsg101 ortho G Tp53 Tsg101 ortho G G G G G G G G Kif28p Tsg101 ortho Protein Traip, RCG25586, isoform CRA_a, TRAF-interacting protein Tsg101 ortho G Protein Rnf126, Ring finger protein 126 Tsg101 ortho G Protein Vrk3, Vaccinia related kinase 3 Tsg101 ortho G G G G G G G G Cope Tsg101 ortho G G G G G G G G Sec24b_predicted Tsg101 ortho G G G G G G Tsg101 Wars ortho G G G G G G G G Trim23 Tsg101 ortho Nr3c2 Tsg101 ortho G G G G G G G Lap3 Tsg101 ortho G G G G G G Tsg101 Aacs ortho G G G G G G G G Hck Tsg101 ortho G G G G G G G G Eukaryotic translation initiation factor 4B, Protein Eif4b Tsg101 ortho G G G G G G G G Syce1 Tsg101 ortho Krt13 Tsg101 ortho Nup54 Tsg101 ortho G G G G G G G Protein Sec23ip, RCG40648, isoform CRA_b Tsg101 ortho Cactin Tsg101 ortho Iqgap1_predicted Tsg101 ortho G G G G G G G G Tsg101 Hip1r ortho G G G G G G G G Dlat Tsg101 ortho Rock1 Tsg101 ortho Cyclin-dependent kinase inhibitor 1A, Cyclin-dependent kinase inhibitor 1A (P21, Cip1), P21, P21 protein, Protein Cdkn1a Tsg101 ortho G G G G G G G Tsg101 Actinin alpha 3, isoform CRA_a, Protein Actn3, Skeletal muscle-specific alpha-actinin 3 ortho G Nxf1 Tsg101 ortho G G G G G G G G Protein Nufip2 Tsg101 ortho Fasn Tsg101 ortho G G G G G G G G Nif3l1 Tsg101 ortho Abcb6 Tsg101 ortho G G G G G G G G Tsg101 Itsn1 ortho Protein Mov10, RCG51996 Tsg101 ortho G G G G G Mogs Tsg101 ortho G G G G G G G G Adrb2 Tsg101 ortho G Cd2ap Tsg101 ortho Polyadenylate-binding protein, PABP Tsg101 ortho Vps37b_predicted Tsg101 ortho G G G G G G G G Ehhadh Tsg101 ortho G G Ushbp1 Tsg101 ortho Pdcd6_predicted Tsg101 ortho G G G G G G G G RGD1565055_predicted Tsg101 ortho G G G G G G G G Protein Vps37a, Similar to DNA segment, Chr 8, ERATO Doi 531, expressed, isoform CRA_c, Vacuolar protein sorting 37 homolog A (S. cerevisiae) Tsg101 ortho G G G Dpysl2 Tsg101 ortho G G G G G G G G Ubc Tsg101 ortho Mgrn1 Tsg101 ortho Pold2 Tsg101 ortho G G G G G G G G Tsg101 Sptbn1 ortho G G G G G G G G Scnn1a Tsg101 ortho G G Tsg101 Ikbkg ortho Tsg101 Nt5dc2 ortho G G G Gcl Tsg101 ortho G G G G G G G G Protein Ppfibp2, Protein tyrosine phosphatase, receptor-type, F interacting protein, binding protein 2, isoform CRA_f Tsg101 ortho G G G G Krt18 Tsg101 ortho G G G G G G Ubap1 Tsg101 ortho G G G G G G G Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a, Protein Nfkb2 Tsg101 ortho G Jun Tsg101 ortho G G G G G G G G Arrdc1 protein, Arrestin domain containing 1, isoform CRA_a, Protein Arrdc1 Tsg101 ortho G G G G G G G G Pck2 Tsg101 ortho G G G Pes1 Tsg101 ortho G G Cebpd Tsg101 ortho G G G Cep55 Tsg101 ortho Tsg101 Trim25 ortho Tsg101 Ankyrin repeat, SAM and basic leucine zipper domain containing 1, GASZ, Protein Asz1 ortho Protein Tnks1bp1 Tsg101 ortho Fnbp1l Tsg101 ortho Tada3 Tsg101 ortho G G G G G G G G Grb2 Tsg101 ortho G G G G G G G G Ndfip1 Tsg101 ortho G G G G G G G G Protein Scamp3 Tsg101 ortho G G G G G G G G Ptprs Tsg101 ortho G G G G G G G G Ube2i Tsg101 ortho G G G G G G G G Dapk3 Tsg101 ortho G G G G G G G G Tsg101 Scgb3a1 ortho Kinesin-like protein Tsg101 ortho G Tff1 Tsg101 ortho G G G G Vasp Tsg101 ortho G G G G G G G G Tsg101 Actn4 ortho G G G G G G G G Protein Rab11fip4, RCG34082 Tsg101 ortho Tsg101 Tsg101 ortho G G G G G G G G LOC687208 protein, Protein Vps37d, RCG21373, isoform CRA_a Tsg101 ortho Arfgap2 Tsg101 ortho G G G G G G G G Protein Mvb12b Tsg101 ortho G G G G G G G G Ctdsp1 protein, Protein Ctdsp1, RCG23761 Tsg101 ortho G G G G G G G G Tsg101 Sars ortho G G G G G G G G Immt Tsg101 ortho G G G G G G G G Tsg101 Ndrg1 ortho G G G G G G G G Golgi associated, gamma adaptin ear containing, ARF binding protein 1, Protein Gga1 Tsg101 ortho G G G G G G G G Ppp1cc Tsg101 ortho G G G G G G G G Krt15 Tsg101 ortho G G LOC684558 Tsg101 ortho Mdm2_predicted Tsg101 ortho G G G G G Tsg101 Xpo1 ortho G G G G G G G G Cdc5l Tsg101 ortho G G G G G G G G Gjc1 Tsg101 ortho Tsg101 Daxx ortho G G G G G G G G Sfpq Tsg101 ortho G G G G G G G Dnajb1_predicted Tsg101 ortho G G G G G G G G Protein Tom1, Target of myb1 homolog (Chicken) Tsg101 ortho G G G G G G G G Caprin1 Tsg101 ortho G G G G G G G G Vps11_predicted Tsg101 ortho G G G G G G G G Tsg101 Pabpc1 ortho G G G G G G G G Hnrpul1_predicted Tsg101 ortho G G G G G G G G Snf8 Tsg101 ortho G G G G G G G G Cops6_predicted Tsg101 ortho G G G G G G G G Tax1bp1 Tsg101 ortho G G G G G G G G Tsg101 Baculoviral IAP repeat-containing 2, Protein Birc2 ortho G G G G G G G G Gjb3 Tsg101 ortho Phosphatidylinositol glycan anchor biosynthesis, class Q, Phosphatidylinositol glycan, class Q, Protein Pigq Tsg101 ortho G G G G G G G G Protein Chmp4b, RCG63680 Tsg101 ortho Tsg101 Pdcd6ip ortho G G G G G G G G Gja1 Tsg101 ortho G G G G G G G G Vcp Tsg101 ortho G G G G G G G G Vps36 Tsg101 ortho G G G G G G G Trim35 Tsg101 ortho G G G G G G G G Tom1l1 Tsg101 ortho Tsg101 Cds2 ortho G Thrsp Tsg101 ortho G G G G G G Tsg101 Sh3kbp1 ortho G G G G G G G G Kallikrein 6, isoform CRA_a, Myelencephalon specific protease, Prostatic glandular kallikrein-6 Tsg101 ortho G G G Wdr12 Tsg101 ortho G G G G G G G G Eno1 Tsg101 ortho G G G G G G G G Cpsf7 Tsg101 ortho G G G G G G G G Tsg101 Men1 ortho G G G G G G G G Tsg101 Mvb12a ortho G G G G G G G G Rad18_predicted Tsg101 ortho Dph2 Tsg101 ortho G G G Protein Ddx6, RCG58047 Tsg101 ortho G G G G G G G Protein Rnf41, Ring finger protein 41 Tsg101 ortho Nfe2 Tsg101 ortho G DNA methyltransferase 1-associated protein 1, Protein Dmap1, RCG50328, isoform CRA_b Tsg101 ortho RGD1561926_predicted Tsg101 ortho Rnf111_predicted Tsg101 ortho G G G G G G G G Protein Adam19, RCG34059 Tsg101 ortho G G G G G G G G Tsg101 Pdlim7 ortho G G G Tsg101 Kcnn4 ortho G Nr3c1 Tsg101 ortho G G G G G G G G Tsg101 Kif5a ortho G G G Ar Tsg101 ortho G G G G G G G Krt31 Tsg101 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9QYW0 Q6IRE4 - 14761944 - X 2 Q6IRE4 Q9NY61 two hybrid 14761944 direct interaction X 2 Q6IRE4 Q9NY61 pull down 14761944 direct interaction X 2 Q6IRE4 pull down 14556380 direct interaction X 2

PPI - HINT Gene A Gene B PMID Method Quality TSG101 AATF 14761944,14761944,14761944 0004,0428,0018 LC SLC2A4 TSG101 16396496 0007 LC SCNN1G TSG101 14556380 0096 LC TSG101 AATF 14761944,14761944,14761944 0004,0428,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NY61 Q6IRE4 AATF TSG101 0.523 14761944 Q6IRE4 P37091 TSG101 SCNN1G 0.309 14556380 Q6IRE4 P19357 TSG101 SLC2A4 0.126 16396496