PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ssb Sumo1 17646655 dip exp G G G G G G G G Cnr1 Sumo1 19819240 biogrid,mint,intact exp G G G G G Kcnb1 Sumo1 21518833 biogrid exp G G G G Sumo1 Sumo3 22082260 biogrid exp G G G G G G G G Cebpa Sumo1 23639777 biogrid exp Sumo1 Kcnip3 21070824 biogrid exp Grik2 Sumo1 doi:d-12-00275,22483987,17486098 mint,intact,dip exp G G G Tollip Sumo1 19198660 biogrid exp G G G G G G G G Sumo1 Daxx 17289031 mint,intact exp, ortho G G G G G G G G Pias4 protein, Protein Pias4, Protein inhibitor of activated STAT, 4 Sumo1 21454665 biogrid exp, ortho G G G Mdm2_predicted Sumo1 17000718 biogrid exp, ortho G G G G G Tp53 Sumo1 19819240 biogrid,mint,intact exp, ortho G G G G G G G G Sumo1 Ikbkg 21454665 biogrid exp, ortho Protein Dtx2, RCG21900, isoform CRA_a Sumo1 ortho G G Sumo1 Kcnk1 ortho G G G G G G Protein LOC102551846 Sumo1 ortho Protein Setx Sumo1 ortho Sumo1 Nr1h4 ortho G G Sumo1 Gcl ortho G G G G G G G G Sumo1 Sept3 ortho Sumo1 Dvl1 ortho G G G G G G G Sumo1 Pias2 ortho G G G G G G G G RGD1309944_predicted Sumo1 ortho Sumo1 Fas ortho Protein Bcl11a Sumo1 ortho Sumo1 Lef1 ortho G Senp6_predicted Sumo1 ortho G G G G G G G G Sumo1 Protein Stom, RCG45489, isoform CRA_a, Stomatin ortho G G G G G G G G Ogt Sumo1 ortho G G G G G G G G Zmym5 Sumo1 ortho Hipk3 Sumo1 ortho Fos Sumo1 ortho G G G G Sumo1 Sart1 ortho G G G G G G G G Protein Zfp462 Sumo1 ortho G G G G G G G G Zfpn1a3_predicted Sumo1 ortho Ar Sumo1 ortho G G G G G G G Zcchc7 Sumo1 ortho Sox10 Sumo1 ortho G G G Park7 Sumo1 ortho G G G G G G G G Tdp2 Sumo1 ortho G G G G G G G G Vcp Sumo1 ortho G G G G G G G G Parp1 Sumo1 ortho G G G G G G G G Ikbke_predicted Sumo1 ortho Slc1a7_predicted Sumo1 ortho G G G G G G G dnmt3b Sumo1 ortho Pias1 Sumo1 ortho Sumo1 Pabpc1 ortho G G G G G G G G Hnrnpk Sumo1 ortho Pfdn2 Sumo1 ortho G G G G G G G G Usp34 Sumo1 ortho G G G G G G G G Nup153 Sumo1 ortho G G G G G G G G Creb1 Sumo1 ortho Sumo1 Tp63 ortho Irf1 Sumo1 ortho G G G G G G G G Ube2d2 Sumo1 ortho G G G G G G G G Casp2 Sumo1 ortho G G G G G G G G Sumo1 Rnf167 ortho G G G G G G G G Anxa2 Sumo1 ortho G G G G G G G G Trp73_predicted Sumo1 ortho Mef2a Sumo1 ortho Sumo2 Sumo1 ortho G G G G G G G G Zfp451 Sumo1 ortho Protein Rara, Retinoic acid receptor, alpha, Retinoic acid receptor, alpha, isoform CRA_b Sumo1 ortho G G Parp12_predicted Sumo1 ortho LOC100363361 Sumo1 ortho G G G G G G G Nf1 Sumo1 ortho Ncoa1_predicted Sumo1 ortho G G G G G G G G Obsl1 Sumo1 ortho Sumo1 Atxn1 ortho G G Hip2_predicted Sumo1 ortho G G G G G G G G Pycs_predicted Sumo1 ortho G G G G G G Nr3c2 Sumo1 ortho G G G G G G G Psmd2 Sumo1 ortho G G G G G G G G Rps3 Sumo1 ortho G G G G G G G G Arpc1b Sumo1 ortho G G G G G G G G Npm1 Sumo1 ortho Sumo1 Methyl-CpG binding domain protein 1, Protein Mbd1 ortho RGD1562258_predicted Sumo1 ortho G Protein Hsf1 Sumo1 ortho G G G G G G G Ncor2_predicted Sumo1 ortho G G G G G G G G Ugdh Sumo1 ortho G G G G G G G G Sumo1 Interferon activated gene 204, Protein Mnda ortho Protein Mkl1 Sumo1 ortho G G G G G G G G Sumo1 Chd8 ortho G G G G G G G G Sumo1 Protein Trim5, Similar to 9230105E10Rik protein ortho G G G G G G G G Sumo1 Zhx1 ortho G G G G G G G G Slc2a1 Sumo1 ortho G G G G G G G G LOC683565 Sumo1 ortho Nkrf Sumo1 ortho G G G G G G G G Mx3 Sumo1 ortho G G Dnm1 Sumo1 ortho G G G G G G G G RGD1311455_predicted Sumo1 ortho G G G G ELK1, Potassium voltage-gated channel subfamily H member 8, RCG42928 Sumo1 ortho G Fsbp Sumo1 ortho Zfp592_predicted Sumo1 ortho G G G G G G G G Sumo1 Sae1 ortho G G G G G G G G Sumo1 Msx1 ortho G G G G G Sumo1 Nfkbia ortho G G G G G RGD1564010_predicted Sumo1 ortho Top2a Sumo1 ortho G Atf2 Sumo1 ortho Sumo1 Dynll2 ortho G G G G G G G G Sumo1 Nr2c1 ortho Protein LOC100909715, Putative uncharacterized protein RGD1308601_predicted Sumo1 ortho Sumo1 Ppil3 ortho G G G G G G G G Prdm1_predicted Sumo1 ortho G G G Protein Zmynd11 Sumo1 ortho G G G G G G G G Kcna5 Sumo1 ortho G Sumo1 Psip1 ortho G G G Chd2_predicted Sumo1 ortho Sumo1 Klf5 ortho G G Sin3a_predicted Sumo1 ortho Arpc4_predicted Sumo1 ortho G G G G G G G G Brca1 Sumo1 ortho G Protein Tfcp2, Tcfcp2 protein Sumo1 ortho Sumo1 Crebbp ortho G G G G G G G Traf4_predicted Sumo1 ortho G G G G G G G G Sumo1 Idh3a ortho G G G G G G G G Pygb Sumo1 ortho G G G G G G G G Protein Sox6, SRY (Sex determining region Y)-box 6 Sumo1 ortho Uba2 Sumo1 ortho G G G G G G G G Pkm Sumo1 ortho Sumo1 Card9 ortho Sumo1 Epas1 ortho Traf6 Sumo1 ortho Arid3a protein, Protein Arid3a Sumo1 ortho Protein Rsbn1 Sumo1 ortho G G G G G G G G Ppp1r10 Sumo1 ortho G G G G G G G G Sumo1 DNA-binding protein SATB ortho Topors_predicted Sumo1 ortho Sumo1 Tank ortho G G Protein Zbtb6, RCG37683 Sumo1 ortho Protein Fan1 Sumo1 ortho Jun Sumo1 ortho G G G G G G G G Srebf1 Sumo1 ortho G G G G G G G G Top2b Sumo1 ortho G G G G G G G G Faslg Sumo1 ortho G G G G Srebf2 Sumo1 ortho G G G G G G G G Sumo1 Vhl ortho G G G G G G G G Protein Uspl1 Sumo1 ortho G G G G G G G G Hipk2_predicted Sumo1 ortho G G G G G Sumo1 Interferon regulatory factor 3, Interferon regulatory factor 3, isoform CRA_c, Protein Irf3 ortho G G G G G G G G Adarb2 Sumo1 ortho G G Mtvr2 Sumo1 ortho G G G G G G G G Rreb1_predicted Sumo1 ortho G G G G G G G G Sumo1 ICSBP ortho Sumo1 Prdx5 ortho G G G G G G G G RCG41622, Sulfhydryl oxidase 1 Sumo1 ortho Eif4e Sumo1 ortho G G G G G G G G Protein Sall1 Sumo1 ortho Polr2g Sumo1 ortho G G G G G G G G Sumo1 Hgs ortho G G G G G G G G Sumo1 Tcf4 ortho G G G G G G G Pax6 Sumo1 ortho G G G G Htt Sumo1 ortho G G G G G G G Cebpb Sumo1 ortho G G G G Sumo1 Sept2 ortho G G G G G G G G Pex2 Sumo1 ortho G G G G G G G G Trim28 Sumo1 ortho G G G G G G G G Sumo1 Park2 ortho Junb Sumo1 ortho G G G G G G G Hif1a Sumo1 ortho G G G G G G G G Glp1r Sumo1 ortho G Protein Wdr33 Sumo1 ortho G G G G G G G G Kpnb1 Sumo1 ortho G G G G G G G G Tnfrsf1a Sumo1 ortho G G G G G G G G Sumo1 Sumo1 ortho G G G G G G G G Phc1_predicted Sumo1 ortho G G G G G G G Capn2 Sumo1 ortho G G G G G G G G Protein Rangap1, RCG59652, isoform CRA_b Sumo1 ortho G G G G G G G G Sumo1 Ccdc67 ortho Ptgs2 Sumo1 ortho Nfe2l2 Sumo1 ortho G G G G G G G G Sumo1 Tdg ortho G G G G Sumo1 Cdk9 ortho G G G G G G G G Sumo1 Ubc ortho Interferon regulatory factor 7, Protein Irf7 Sumo1 ortho G G G G G G G G RGD1306498_predicted Sumo1 ortho Sumo1 Birc3 ortho G G G G G Sumo1 Rbbp7 ortho G G G G G G G G Sumo1 Actinin alpha 3, isoform CRA_a, Protein Actn3, Skeletal muscle-specific alpha-actinin 3 ortho G Nup107 Sumo1 ortho Sumo1 Zfp145 ortho Dhx30 Sumo1 ortho G G G G G G G Sumo1 Pdgfc ortho Trps1_predicted Sumo1 ortho Sumo1 Hdac4 ortho G Prox1_predicted Sumo1 ortho Protein Zfp317 Sumo1 ortho Mitf Sumo1 ortho G G G G G G Sumo1 Sptbn1 ortho G G G G G G G G Protein LOC100911267, RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae), Similar to DNA repair protein RAD51 homolog 1 (Predicted) Sumo1 ortho Histone deacetylase Sumo1 ortho LOC683923 Sumo1 ortho Rnf4 Sumo1 ortho G G G G G G G G Rwdd3 Sumo1 ortho Sumo1 Senp2 ortho G G G G G G G Cdc40 Sumo1 ortho G G G G G G G G Ptpn1 Sumo1 ortho G G Sumo1 Casp8 ortho G Bckdk Sumo1 ortho G G G G G G G Mtor Sumo1 ortho G G G G G G G G Dyrk2_predicted Sumo1 ortho G Zbtb26_predicted Sumo1 ortho Protein Casp8ap2, RCG55124 Sumo1 ortho Sumo1 Ncoa2 ortho Cdc5l Sumo1 ortho G G G G G G G G Sumo1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a, Protein Nfkb2 ortho G Ube2i Sumo1 ortho G G G G G G G G Maf Sumo1 ortho G G Fam118b Sumo1 ortho Pias3 Sumo1 ortho G G G G G G G G Uncharacterized protein C11orf65 homolog Sumo1 ortho G G Intestinal-type alkaline phosphatase 2, IAP-2, Intestinal alkaline phosphatase 2 Sumo1 ortho Prkacb Sumo1 ortho Toe1_predicted Sumo1 ortho G G Sumo1 Ppm1j ortho G Sumo1 Top1 ortho G G G G G G G G Rnf111_predicted Sumo1 ortho G G G G G G G G Irak1_predicted Sumo1 ortho G G G G G G G G Smad4 Sumo1 ortho G G G G G G G G Protein Rbak Sumo1 ortho Egr1 Sumo1 ortho G G G G G G G G Foxm1 Sumo1 ortho G Sumo1 Uimc1 ortho G G G G G G G G Ing1 Sumo1 ortho G G G G G G G G LOC299827 Sumo1 ortho G G G G G G G G Atxn3 Sumo1 ortho Zcchc12 Sumo1 ortho G G G G G G G G Ets variant 6, Protein Etv6 Sumo1 ortho Nr3c1 Sumo1 ortho G G G G G G G G Sumo1 Kat5 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5I0H3 affinity chromatography technology 16955485 physical association X 2 Q5I0H3 two hybrid 16144832 direct interaction X 2 P10361 Q5I0H3 affinity chromatography technology 19819240 physical association X 2 Q5I0H3 fluorescent resonance energy transfer 21518833 direct interaction X 2 Q5I0H3 affinity chromatography technology 21454665 physical association X 2 A2RUW1 Q5I0H3 two hybrid 19198660 direct interaction X 2 A2RUW1 Q5I0H3 pull down 19198660 direct interaction X 2 A2RUW1 Q5I0H3 affinity chromatography technology 19198660 physical association X 2 P70579 Q5I0H3 affinity chromatography technology 16144832 physical association X 2 Q5I0H3 affinity chromatography technology 21070824 physical association X 2 Q5XIF4 Q5I0H3 affinity chromatography technology 22082260 physical association X 2 Q5I0H3 affinity chromatography technology 17000718 physical association X 2 Q6TMG5 Q5I0H3 affinity chromatography technology 21454665 physical association X 2 Q5I0H3 affinity chromatography technology 21454665 physical association X 2 P05554 Q5I0H3 affinity chromatography technology 23639777 physical association X 2 P20272 Q5I0H3 affinity chromatography technology 19819240 physical association X 2 Q5I0H3 anti bait coimmunoprecipitation 17486098 physical association X 2 Q5I0H3 anti bait coimmunoprecipitation 17486098 physical association X 2 Q5I0H3 anti tag coimmunoprecipitation 22089239 physical association X 2 Q5I0H3 anti bait coimmunoprecipitation 17486098 physical association X 2 P05455 Q5I0H3 anti tag coimmunoprecipitation 17646655 physical association X 2 Q5I0H3 anti bait coimmunoprecipitation 17646655 physical association X 2 Q5I0H3 anti tag coimmunoprecipitation 17646655 physical association X 2 Q5I0H3 anti bait coimmunoprecipitation 17646655 physical association X 2 P42260 Q5I0H3 anti bait coimmunoprecipitation 22483987 physical association X 2 P10361 Q5I0H3 anti bait coimmunoprecipitation 19819240 physical association X 2 Q8VIB2 Q5I0H3 imaging technique 17289031 colocalization X 2 P20272 Q5I0H3 anti bait coimmunoprecipitation 19819240 physical association X 2 P20272 Q5I0H3 fluorescence microscopy 19819240 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Tp53 Sumo1 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19819240 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_335196|MINT_73874|UniProt_183337 bait|bait|bait prey|prey|prey Kcnb1 Sumo1 MI:0055(fluorescent resonance energy transfer) 21518833 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_334170 bait prey Grm8 Sumo1 MI:0018(two hybrid) 16144832 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_337062 prey bait Grik2 Sumo1 MI:0006(anti bait coimmunoprecipitation) 22483987 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (intact) UniProt_185739 prey bait Sumo1 Ncoa3 MI:0004(affinity chromatography technology) 21454665 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334418 prey bait Sumo1 Tollip MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_335239|BIOGRID_335229|BIOGRID_335246 prey|prey|prey bait|bait|bait Sumo1 Kcnip3 MI:0018(two hybrid) 21070824 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334167 prey bait Ssb Sumo1 MI:0007(anti tag coimmunoprecipitation) 17646655 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) MI:0465(dip) DIP_5251 - - Sumo1 Syt7 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21266332 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_334228|BIOGRID_334227 bait|prey prey|bait Sumo1 Park2 MI:0004(affinity chromatography technology) 16955485 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333736 bait prey Cnr1 Sumo1 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19819240 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) BIOGRID_335199|UniProt_183339|UniProt_183338|MINT_73875|MINT_73876 bait|neutral component|bait|bait|neutral component prey|neutral component|prey|prey|neutral component Sumo1 Pias4 MI:0004(affinity chromatography technology) 21454665 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334422 prey bait Sumo1 Daxx MI:0428(imaging technique)|MI:0428(imaging technique) 17289031 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization)|MI:0403(colocalization) (intact)|MI:0471(mint) UniProt_183265|MINT_86602 neutral component|neutral component neutral component|neutral component Sumo1 Sumo3 MI:0004(affinity chromatography technology) 22082260 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334306 prey bait Sumo1 Ikbkg MI:0004(affinity chromatography technology) 21454665 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334419 prey bait Sumo1 Mdm2 MI:0004(affinity chromatography technology) 17000718 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334583 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TOLLIP SUMO1 19198660,19198660,19198660 0096,0018,0004 LC KCNB1 SUMO1 21518833 0055 LC CNR1 SUMO1 19819240,19819240,19819240 0004,0416,0006 LC TOLLIP SUMO1 19198660,19198660,19198660 0096,0018,0004 LC PIAS4 SUMO1 21454665 0004 LC MDM2 SUMO1 17000718 0004 LC CEBPA SUMO1 23639777 0004 LC TP53 SUMO1 19819240,19819240 0004,0006 LC CNR1 SUMO1 19819240,19819240,19819240 0004,0416,0006 LC SSB SUMO1 17646655,17646655 0006,0007 LC GRIK2 SUMO1 17486098,22483987,22089239 0006,0006,0007 LC SUMO1 SUMO3 22082260 0004 LC SUMO1 SYT7 21266332 0004 LC SUMO1 IKBKG 21454665 0004 LC SUMO1 DAXX 17289031 0428 LC SUMO1 PARK2 16955485 0004 LC SUMO1 KCNIP3 21070824 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5I0H3 P05455 SUMO1 SSB 0.21 17646655 Q5I0H3 P42260 SUMO1 GRIK2 0.21 22483987 Q5XIF4 Q5I0H3 SUMO3 SUMO1 0.126 22082260 Q9JM47 Q5I0H3 KCNIP3 SUMO1 0.21 21070824 Q6TMG5 Q5I0H3 IKBKG SUMO1 0.21 21454665 Q5I0H3 P05554 SUMO1 CEBPA 0.21 23639777 Q8VIB2 Q5I0H3 DAXX SUMO1 0.236 17289031 Q5I0H3 P10361 SUMO1 TP53 0.376 19819240 Q5I0H3 P38656 SUMO1 SSB 0.376 17646655 Q5I0H3 A2RUW1 SUMO1 TOLLIP 0.623 19198660 Q5I0H3 P47743 SUMO1 GRM8 0.309 16144832 Q5I0H3 P20272 SUMO1 CNR1 0.454 19819240 Q5I0H3 P15387 SUMO1 KCNB1 0.309 21518833