PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Tollip Pias2 19198660 biogrid exp G G G G G G G G Tollip Daxx 19198660 biogrid exp G G G G G G G G Tollip Bex1 19198660 biogrid exp Tollip Ap2b1 16903783 biogrid exp G G G G G G G G Tollip Ing1 19198660 biogrid exp G G G G G G G G Tollip Ube2i 19198660 biogrid exp G G G G G G G G Tollip Gnb2l1 19198660 biogrid exp G G G G G G G G Tollip Sumo1 19198660 biogrid exp G G G G G G G G Tollip Il1rap 19198660 biogrid exp, ortho G Tollip Protein Tom1, Target of myb1 homolog (Chicken) 19198660 biogrid exp, ortho G G G G G G G G Tollip Tollip 19198660 biogrid exp, ortho G G G G G G G G Tollip Rps27 19198660 biogrid exp, ortho Tollip Ubc 19198660 biogrid exp, ortho Tollip Il1r1 19198660 biogrid exp, ortho G Tollip Tlr9 ortho Tollip Odam ortho Tollip Xpo1 ortho G G G G G G G G Tollip Nbr1 ortho Tollip Csn2 ortho Tollip Protein LOC100911180 ortho Tollip Nt5dc2 ortho G G G Tollip Wdyhv1 ortho Tollip Atp8b2 ortho G G G G G G G Tollip Toll-like receptor ortho Tollip Tom1l1 ortho Tollip Sept1 ortho G Tollip Smad7 ortho Tollip Cpsf6_predicted ortho G G Tollip Golgi associated, gamma adaptin ear containing, ARF binding protein 2, isoform CRA_a, Protein Gga2 ortho G G G G G G G G Tollip Irak1_predicted ortho G G G G G G G G Tollip Apeh ortho G G G G G G G G Tollip Protein Sun1, Unc-84 homolog A (C. elegans) ortho Tollip Tlr3 ortho Tollip Traf6 ortho Tollip High mobility group AT-hook 2, Non-histone chromosomal architectural protein HMGI-C, Protein Hmga2 ortho Tollip Gga3_predicted ortho G G G G G G G Tollip Ptbp3 ortho G Tollip Rps25 ortho Tollip Itch ortho Tollip Tmem17 ortho Tollip SUP ortho G G G G G G G G Rbfox2 Tollip ortho G G G G G G Tollip Bhlhe40 ortho G G Tollip Oxr1 ortho G G G G G G G G Tollip Maged1 ortho G G G G G G G G Tollip Protein Secisbp2l ortho G G G G G G G G Tollip Cstf1 ortho G G G G Tollip Zhx1 ortho G G G G G G G G Tollip Siah1 ortho G G G Tollip Cav1 ortho G G G G G G Tollip Nucb1 ortho G G G G G G G G Tollip Atxn1 ortho G G Tollip Tgfbr1 ortho G G G G G G G G Tollip Ankyrin repeat domain 13a, Protein Ankrd13a, RCG21176 ortho G G G G G G G G Tollip RGD1565135_predicted ortho G G G G G G G G Tollip Sqstm1 ortho G G G G G G G G Tollip Protein Leng8, RCG22627, isoform CRA_c ortho G G G G G G G G Tollip Flot1 ortho G G G G G G G G Tollip Eif2ak2 ortho G G G G Tollip Snx8_predicted ortho Tollip Baculoviral IAP repeat-containing 2, Protein Birc2 ortho G G G G G G G G Tollip Araf ortho G G G G G Tollip Zfp145 ortho Tollip Map1lc3a ortho G G G G G G G G Tollip Htt ortho G G G G G G G Tollip Golgi associated, gamma adaptin ear containing, ARF binding protein 1, Protein Gga1 ortho G G G G G G G G Tollip Rac1 ortho G G G G G G G G Tollip Wrnip1 ortho G G G G G G G G Tollip Xrn2_predicted ortho G G G G G G G G Tollip Mapk7 ortho G G G G G G G G Tollip Ywhae ortho G G G G G G G G Tollip Xiap ortho Tollip Tcaf1 ortho G G G G G G G G Tollip Cyhr1 ortho Tollip LOC686323 protein, Protein Trip6, RCG21591, isoform CRA_a ortho G G G G Tollip Nmi ortho Tollip Ldb1_predicted ortho G G G G G G G G Tollip Tbx3 ortho G G G Tollip Elavl4 ortho G G G G G G G G Tollip Dab1 ortho Tollip Krt8 ortho G G G G G G Tollip Protein Rbpms ortho G G G G G G G G Tollip Vps35_mapped ortho G G G G G G G G Tollip Irak2 ortho Tollip Vps29 ortho G G G G G G G G Tollip Tlr4 ortho G Tollip Chd6 ortho G G G G Tollip Abcb6 ortho G G G G G G G G Tollip Pink1_predicted ortho G G G G G G G G Tollip Tom1l2_predicted ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P63281 A2RUW1 two hybrid 19198660 direct interaction X 2 P63281 A2RUW1 pull down 19198660 direct interaction X 2 P63281 A2RUW1 affinity chromatography technology 19198660 physical association X 2 Q63429 A2RUW1 two hybrid 19198660 direct interaction X 2 P62944-2 A2RUW1 affinity chromatography technology 16903783 physical association X 2 A2RUW1 pull down 19198660 direct interaction X 2 A2RUW1 two hybrid 19198660 direct interaction X 2 A2RUW1 two hybrid 19198660 direct interaction X 2 A2RUW1 Q5I0H3 two hybrid 19198660 direct interaction X 2 A2RUW1 Q5I0H3 pull down 19198660 direct interaction X 2 A2RUW1 Q63621 pull down 19198660 direct interaction X 2 A2RUW1 Q5I0H3 affinity chromatography technology 19198660 physical association X 2 A2RUW1 affinity chromatography technology 23695782 physical association X 2 A2RUW1 two hybrid 19198660 direct interaction X 2 A2RUW1 pull down 19198660 direct interaction X 2 A2RUW1 two hybrid 19198660 direct interaction X 2 A2RUW1 pull down 19198660 direct interaction X 2 A2RUW1 affinity chromatography technology 19198660 physical association X 2 Q71TY3 A2RUW1 two hybrid 19198660 direct interaction X 2 A2RUW1 two hybrid 19198660 direct interaction X 2 A2RUW1 A2RUW1 two hybrid 19198660 direct interaction X 2 A2RUW1 A2RUW1 pull down 19198660 direct interaction X 2 P63245 A2RUW1 two hybrid 19198660 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Il1r1 Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335243 prey bait Tollip COI MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:691974() MI:0407(direct interaction) (biogrid) BIOGRID_335235 bait prey Gnb2l1 Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335232 prey bait Rps27 Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335236 prey bait Ubc Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335233 prey bait Sumo1 Tollip MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_335239|BIOGRID_335229|BIOGRID_335246 prey|prey|prey bait|bait|bait Ube2i Tollip MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_335225|BIOGRID_335237|BIOGRID_335244 prey|prey|prey bait|bait|bait Ap2b1 Tollip MI:0004(affinity chromatography technology) 16903783 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335410 bait prey Daxx Tollip MI:0018(two hybrid)|MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_335226|BIOGRID_335238 prey|prey bait|bait Pias2 Tollip MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_335228|BIOGRID_335245|BIOGRID_335241 prey|prey|prey bait|bait|bait Ing1 Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335234 prey bait Tom1 Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335227 prey bait Bex1 Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335231 prey bait Il1rap Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335242 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TOLLIP TOLLIP 19198660,19198660 0096,0018 LC TOLLIP RACK1 19198660 0018 LC TOLLIP UBE2I 19198660,19198660,19198660 0096,0018,0004 LC TOLLIP ING1 19198660 0018 LC TOLLIP BEX1 19198660 0018 LC TOLLIP SUMO1 19198660,19198660,19198660 0096,0018,0004 LC TOLLIP TOM1 19198660 0018 LC TOLLIP UBC 19198660 0018 LC TOLLIP PIAS2 19198660,19198660,19198660 0096,0018,0004 LC TOLLIP RPS27 19198660 0018 LC TOLLIP DAXX 19198660,19198660 0096,0018 LC TOLLIP TOLLIP 19198660,19198660 0096,0018 LC TOLLIP AP2B1 16903783 0004 LC TOLLIP UBE2I 19198660,19198660,19198660 0096,0018,0004 LC TOLLIP IL1R1 19198660 0096 LC TOLLIP SUMO1 19198660,19198660,19198660 0096,0018,0004 LC TOLLIP IL1RAP 19198660 0096 LC TOLLIP PIAS2 19198660,19198660,19198660 0096,0018,0004 LC TOLLIP DAXX 19198660,19198660 0096,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID A2RUW1 A2RUW1 TOLLIP TOLLIP 0.554 19198660 P63281 A2RUW1 UBE2I TOLLIP 0.623 19198660 Q5I0H3 A2RUW1 SUMO1 TOLLIP 0.623 19198660 Q6AZ28 A2RUW1 PIAS2 TOLLIP 0.623 19198660 P63245 A2RUW1 GNB2L1 TOLLIP 0.309 19198660 Q3MKQ2 A2RUW1 BEX1 TOLLIP 0.309 19198660 Q63429 A2RUW1 UBC TOLLIP 0.309 19198660 Q63621 A2RUW1 IL1RAP TOLLIP 0.309 19198660 Q71TY3 A2RUW1 RPS27 TOLLIP 0.309 19198660 P62944 A2RUW1 AP2B1 TOLLIP 0.21 16903783