PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Grik2 Map3k11 doi:d-12-00275,22483987 mint,intact exp G G G Protein Cbl Map3k11 19546888 biogrid exp, ortho Hspa4 Map3k11 ortho G G G G G G G G Akt1 Map3k11 ortho G G G G G G G G Tnk1_predicted Map3k11 ortho Chuk_predicted Map3k11 ortho G G G G G G G G Smad4 Map3k11 ortho G G G G G G G G Nf2 Map3k11 ortho G G G G G G G G Hsp90ab1 Map3k11 ortho G G G G G G G G Protein Rhog, Ras homolog gene family, member G, Ras homolog gene family, member G (Rho G) Map3k11 ortho G G G G G G G G Kinesin-like protein Map3k11 ortho G Map3k11 Mapk8ip1 ortho G G G G G G G G Nr3c2 Map3k11 ortho G G G G G G G Igf1r Map3k11 ortho G G G G G G G G Protein Stub1, STIP1 homology and U-Box containing protein 1, isoform CRA_b Map3k11 ortho G G G G G G G G Map2k4 Map3k11 ortho Pkm Map3k11 ortho Mapk8ip3 Map3k11 ortho Map3k12 Map3k11 ortho G G G G G G G G Dlg4 Map3k11 ortho G G G G G G Map4k1_predicted Map3k11 ortho G Mitogen-activated protein kinase 8 interacting protein 2, Protein Mapk8ip2 Map3k11 ortho Cdc37 Map3k11 ortho G G G G G G G G Map2k1 Map3k11 ortho G G G G G G G G App Map3k11 ortho G G G G G G G G Traf2_predicted Map3k11 ortho Scnn1b Map3k11 ortho G G G G G G G G Mapk8 Map3k11 ortho G G G G G G G G Map3k11 Daxx ortho G G G G G G G G Gsk3a Map3k11 ortho G G G G G G G G Map3k11 Ikbkb ortho G G G G G G G G Map3k11 Sh3rf1 ortho Hsp90aa1 Map3k11 ortho Camkk2 Map3k11 ortho G G Pik3r1 Map3k11 ortho G Protein Map3k9 Map3k11 ortho Cyclin-dependent kinase 6, Protein Cdk6 Map3k11 ortho PDZ domain-containing protein 2, Peptidylprolyl cis/trans isomerase, NIMA-interacting 1, Protein (Peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Predicted), isoform CRA_a Map3k11 ortho G G G G G G G G Map3k11 Map3k11 ortho G G G G G G G G Eps8 Map3k11 ortho COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 Map3k11 ortho G G G G G G G G Map3k11 Protein Trim5, Similar to 9230105E10Rik protein ortho G G G G G G G G Cdk12 Map3k11 ortho Taok3 Map3k11 ortho Map3k11 Rac1 ortho G G G G G G G G Gsk3b Map3k11 ortho G G Map2k7 Map3k11 ortho Pkn1 Map3k11 ortho G G G Traf6 Map3k11 ortho Irak1_predicted Map3k11 ortho G G G G G G G G E2f1 Map3k11 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q66HA1 affinity chromatography technology 19546888 physical association X 2 Q66HA1 A0A024RAE4 anti tag coimmunoprecipitation 20890305 physical association X 2 P42260 Q66HA1 anti bait coimmunoprecipitation 22483987 physical association X 2 P42260 Q66HA1 anti bait coimmunoprecipitation 22483987 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Grik2 Map3k11 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 22483987 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_185741|UniProt_185740 prey|prey bait|bait Map3k11 Cbl MI:0004(affinity chromatography technology) 19546888 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335755 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q66HA1 P42260 MAP3K11 GRIK2 0.21 22483987