PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Plcb1 Cdc20 19347873 biogrid exp G G G Cdc20 Hdac6 19167333 intact exp Camk2b Cdc20 21725312 biogrid exp G G G Ywhae Cdc20 19167333 biogrid exp G G G Kras Cdc20 22045811 biogrid exp G G G Tubg1 Cdc20 19167333 biogrid exp, ortho G G G Id1 Cdc20 19167333 intact exp, ortho G G G Cdc27 Cdc20 22045811 biogrid exp, ortho Cct8_predicted Cdc20 ortho G G G Axin2 Cdc20 ortho G G G Anapc10_predicted Cdc20 ortho Raver1 Cdc20 ortho G G Protein Anapc16, RCG22080, isoform CRA_b Cdc20 ortho G G G App Cdc20 ortho G G G Prkacb Cdc20 ortho Cerebellar degeneration-related 2, Cerebellar degeneration-related 2, isoform CRA_a, Protein Cdr2 Cdc20 ortho G G G Cdc20 Stau1 ortho G G G Kinesin-like protein Cdc20 ortho G Cdc20 Cct5 ortho G G G Cdc5l Cdc20 ortho G G G Hspa5 Cdc20 ortho G G G Anapc1_predicted Cdc20 ortho G Cdc20 Ccna1 ortho Fbxw5 Cdc20 ortho G G G Cct2 Cdc20 ortho G G G Cdc20 Cdk2 ortho Cdc20 Cyclin-dependent kinase inhibitor 1A, Cyclin-dependent kinase inhibitor 1A (P21, Cip1), P21, P21 protein, Protein Cdkn1a ortho G G Chaperonin containing Tcp1, subunit 6A (Zeta 1), Chaperonin subunit 6a (Zeta), Protein Cct6a Cdc20 ortho G G G Tpx2_predicted Cdc20 ortho Protein Phf8, RCG38940 Cdc20 ortho Hdac2 Cdc20 ortho G G G CDC16 cell division cycle 16 homolog (S. cerevisiae), Protein Cdc16 Cdc20 ortho G G G Fry Cdc20 ortho G G Protein Mad1l1, RCG42782, isoform CRA_a Cdc20 ortho G G Cdc20 Cb1-727, Platelet-derived growth factor subunit A ortho G G G Rpl23 Cdc20 ortho G G G Hspa4 Cdc20 ortho G G G Ccnb1 Cdc20 ortho G G Protein Smpd5, Similar to sphingomyelin phosphodiesterase 3, neutral membrane (Predicted) Cdc20 ortho Hspa9 Cdc20 ortho Pim1 Cdc20 ortho G Protein Cct7, RCG55994, isoform CRA_c Cdc20 ortho G G G Checkpoint with forkhead and ring finger domains, Checkpoint with forkhead and ring finger domains, isoform CRA_b, Protein Chfr Cdc20 ortho Fbxo5_predicted Cdc20 ortho LOC316395 Cdc20 ortho Cdc20 hsf2 ortho G G Protein Mov10, RCG51996 Cdc20 ortho G G G Tgfbr1 Cdc20 ortho G G G Hspd1 Cdc20 ortho G G G Protein Cit Cdc20 ortho G G G Cdc20 Xpo1 ortho G G G Anapc2 protein, Anaphase promoting complex subunit 2, Protein Anapc2 Cdc20 ortho G G G Protein Ruvbl2, RuvB-like 2 (E. coli) Cdc20 ortho G G G Bub1_predicted Cdc20 ortho Clspn_predicted Cdc20 ortho Ttk_predicted Cdc20 ortho Trp73_predicted Cdc20 ortho Protein Spint2, Serine protease inhibitor, Kunitz type 2 Cdc20 ortho G G G Anaphase promoting complex subunit 4, isoform CRA_a, Protein Anapc4 Cdc20 ortho G G G Cdc20 Ccnf ortho COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 Cdc20 ortho G G G Ube2s Cdc20 ortho G G G Protein Cdc23 Cdc20 ortho G G Ccne2_predicted Cdc20 ortho G Mdh2 Cdc20 ortho G G G RGD1561880_predicted Cdc20 ortho G G G Mxi1 Cdc20 ortho G G G Yars2 Cdc20 ortho Cdc20 Rnf34 ortho G G G Cdk4 Cdc20 ortho G G G E2f1 Cdc20 ortho Mdc1 Cdc20 ortho G Hspa1l Cdc20 ortho Fgfr1 Cdc20 ortho G G G Cdc20 Cdc26 ortho G G G Tuba4a Cdc20 ortho G G G Sirt2 Cdc20 ortho G G G Tfdp1 Cdc20 ortho G G G Cdc20 Cct3 ortho G G G Protein Ube2c, RCG32249 Cdc20 ortho G G G CPVL Cdc20 ortho Cyclin A2, isoform CRA_b, Protein Ccna2 Cdc20 ortho Tubb2a Cdc20 ortho G G G Tuba1a Cdc20 ortho Cdc20 Krt32 ortho Anapc7_predicted Cdc20 ortho G G Mad2l1_predicted Cdc20 ortho G Btrc Cdc20 ortho G G G Usp34 Cdc20 ortho G G G Hdac1 Cdc20 ortho G Cdc20 Crebbp ortho G G Ccnb2 Cdc20 ortho G Aurkb Cdc20 ortho G Gmnn_predicted Cdc20 ortho Tcp1 Cdc20 ortho G G G Ccdc59_predicted Cdc20 ortho RGD1562456_predicted Cdc20 ortho Cdc20 Fbxo43 ortho MAD2L1 binding protein, Protein Mad2l1bp Cdc20 ortho G G G Pttg1 Cdc20 ortho G G Protein Plekho2 Cdc20 ortho Cdc20 Cdc20 ortho G G G Prkaca Cdc20 ortho G G G Rnh1 Cdc20 ortho G G G Ris2_predicted Cdc20 ortho Protein Anapc13, RCG26082, isoform CRA_a Cdc20 ortho G G G Fez1 Cdc20 ortho G Cdc6_predicted Cdc20 ortho Hdac11_predicted Cdc20 ortho G Cdc20 RelA ortho G G G Aurka Cdc20 ortho G Ist1 Cdc20 ortho G G G Cdc20 Sostdc1 ortho G Cdc20 Krt31 ortho Polymerase (RNA) II (DNA directed) polypeptide C, 33kDa, Polymerase (RNA) II (DNA directed) polypeptide C, isoform CRA_b, Protein Polr2c Cdc20 ortho G G Cdc7_predicted Cdc20 ortho Cdk1 Cdc20 ortho G G G Pcna Cdc20 ortho G G G Krt85 Cdc20 ortho LOC100362620 Cdc20 ortho G G LOC497975 Cdc20 ortho G G G Dnaja2 Cdc20 ortho G G G Pou2f1 Cdc20 ortho Cuedc2 Cdc20 ortho G G Cdc20 Plk1 ortho G Apc Cdc20 ortho Protein Rassf1, Ras association (RalGDS/AF-6) domain family 1, isoform CRA_b, Ras association domain family 1 isoform A Cdc20 ortho G G Cdc20 Hnrnpf ortho G G Cdc20 Tubb4b ortho G G G Anapc5 Cdc20 ortho G G G Cdc20 Cct4 ortho G G G Cdc20 Tas2r13 ortho Uba52 Cdc20 ortho G G G Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2A, isoform CRA_a Cdc20 ortho Fzr1_predicted Cdc20 ortho G G Tubb5 Cdc20 ortho G G G Bub3 Cdc20 ortho G G G Rps3 Cdc20 ortho G G G Tk1 Cdc20 ortho G G G Protein Hsf1 Cdc20 ortho G G Hspa8 Cdc20 ortho Cdc20 Daxx ortho G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62623 biochemical 21725312 colocalization X 2 Q62623 affinity chromatography technology 21725312 physical association X 2 Q62623 Q4V8A2 affinity chromatography technology 22045811 physical association X 2 Q62623 P83888 biochemical 19167333 colocalization X 2 Q62623 affinity chromatography technology 22045811 physical association X 2 Q62623 pull down 22045811 direct interaction X 2 Q62623 biochemical 19167333 colocalization X 2 P10687 Q62623 affinity chromatography technology 19347873 physical association X 2 P10687 Q62623 affinity chromatography technology 19347873 physical association X 2 P10687 Q62623 affinity chromatography technology 19347873 physical association X 2 Q99P97 Q62623 anti bait coimmunoprecipitation 19167333 physical association X 2 Q62623 A0A024QZ26 anti tag coimmunoprecipitation 19167333 physical association X 2 Q62623 A0A024QZ26 pull down 19167333 physical association X 2 P41135 Q62623 anti tag coimmunoprecipitation 19167333 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Cdc20 Hdac6 MI:0007(anti tag coimmunoprecipitation) 19167333 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (intact) UniProt_183109 bait prey Ywhae Cdc20 MI:0004(affinity chromatography technology) 19167333 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (biogrid) BIOGRID_336083 prey bait Id1 Cdc20 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 19167333 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_183108|UniProt_99471 prey|prey bait|bait Camk2b Cdc20 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21725312 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid) BIOGRID_337071|BIOGRID_337068 prey|bait bait|prey Kras Cdc20 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22045811 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_334051|BIOGRID_334053 bait|bait prey|prey Tubg1 Cdc20 MI:0004(affinity chromatography technology) 19167333 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (biogrid) BIOGRID_336084 prey bait Plcb1 Cdc20 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19347873 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_335119|BIOGRID_335118|BIOGRID_335117 prey|bait|bait bait|prey|prey Cdc27 Cdc20 MI:0004(affinity chromatography technology) 22045811 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334055 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CAMK2B CDC20 21725312,21725312 0401,0004 LC YWHAE CDC20 19167333 0401 LC TUBG1 CDC20 19167333 0401 LC CAMK2B CDC20 21725312,21725312 0401,0004 LC KRAS CDC20 22045811,22045811 0004,0096 LC PLCB1 CDC20 19347873 0004 LC ID1 CDC20 19167333 0007 LC YWHAE CDC20 19167333 0401 LC TUBG1 CDC20 19167333 0401 LC CDC27 CDC20 22045811 0004 LC CDC20 HDAC6 19167333 0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q62623 P10687 CDC20 PLCB1 0.376 19347873 Q62623 P08413 CDC20 CAMK2B 0.309 21725312 Q62623 P62260 CDC20 YWHAE 0.126 19167333 Q62623 P83888 CDC20 TUBG1 0.126 19167333 Q62623 P08644 CDC20 KRAS 0.454 22045811 Q99P97 Q62623 HDAC6 CDC20 0.21 19167333 Q9UBN7 Q62623 HDAC6 CDC20 0.376 19167333 Q62623 P41135 CDC20 ID1 0.21 19167333 Q62623 Q4V8A2 CDC20 CDC27 0.21 22045811