PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Tceb1 Tceb3 19037258 biogrid,intact exp G G G G Tceb2 Tceb1 11384984,10224134 biogrid exp G G G G G G G G Nr3c1 Tceb1 16619302 intact exp G G G G G G G G Tceb1 Lrrc41 11384984 biogrid exp G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P83941 A0A024R475 affinity chromatography technology 19037258 physical association X 2 P83941 Q3TCH7 affinity chromatography technology 19037258 physical association X 2 Q5M9H1 P83941 biochemical 11384984 colocalization X 2 P83941 P40337-3 affinity chromatography technology 9341197 physical association X 2 P83941 P40337-3 pull down 9341197 direct interaction X 2 P83941 A0A024R730 affinity chromatography technology 17110338 physical association X 2 P83941 Q93034 affinity chromatography technology 19037258 physical association X 2 P83941 affinity chromatography technology 19037258 physical association X 2 P62870 P83941 pull down 10224134 direct interaction X 2 P62870 P83941 biochemical 11384984 colocalization X 2 P83941 coimmunoprecipitation 12149480 association C 5 P83941 chromatography technology 10213691 association C 5 P83941 molecular sieving 10213691 association C 5 P83941 coimmunoprecipitation 11384984 association C 5 P83941 coimmunoprecipitation 11384984 association C 5 P83941 coimmunoprecipitation 11384984 association C 5 P83941 coimmunoprecipitation 11384984 association C 5 P83941 coimmunoprecipitation 11384984 association C 5 P83941 coimmunoprecipitation 11384984 association C 5 P83941 reverse phase chromatography 8244996 association C 3 P83941 coimmunoprecipitation 15590664 association C 5 P83941 anti bait coimmunoprecipitation 16619302 association C 24 P83941 anti tag coimmunoprecipitation 19037258 association C 6 P83941 anti tag coimmunoprecipitation 19037258 association C 6 P83941 anti tag coimmunoprecipitation 19037258 association C 5 P83941 anti tag coimmunoprecipitation 19037258 association C 5 P83941 anti tag coimmunoprecipitation 19037258 association C 5

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Tceb2 Tceb1 MI:0096(pull down)|MI:0004(affinity chromatography technology) 10224134,11384984 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_333565|BIOGRID_335132 bait|bait prey|prey Tceb1 Tceb3 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 10,19037258 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(biogrid) UniProt_97849|MINT_73993|MINT_73995|UniProt_97850|UniProt_168995|UniProt_183304|UniProt_183303|UniProt_168996|MINT_43852|MINT_43854|UniProt_97852|MINT_73996|UniProt_97851|MINT_73997|MINT_43856|MINT_43855|UniProt_168997|UniProt_183306|UniProt_168998|UniProt_183305|BIOGRID_334442 prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|prey bait|prey|bait|prey|bait|prey|bait|prey|prey|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait|bait Tceb1 Lrrc41 MI:0096(pull down) 11384984 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (biogrid) BIOGRID_333563 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TCEB2 TCEB1 11384984 0401 LC TCEB1 LRRC41 11384984 0401 LC NR3C1 TCEB1 16619302 0006 LC TCEB2 TCEB1 11384984,10224134 0401,0096 LC TCEB1 LRRC41 11384984 0401 LC TCEB1 TCEB3 19037258,19037258 0004,0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5M9H1 P83941 LRRC41 TCEB1 0.126 11384984 Q63187 P83941 TCEB3 TCEB1 0.21 19037258 P83941 P13569 TCEB1 CFTR 0.126 17110338 P83941 P06536 TCEB1 NR3C1 0.21 16619302 Q93034 P83941 CUL5 TCEB1 0.376 19037258 Q3TCH7 P83941 CUL4A TCEB1 0.376 19037258 P83941 P62870 TCEB1 TCEB2 0.396 11384984,10224134 P83941 P40337 TCEB1 VHL 0.454 9341197 Q13618 P83941 CUL3 TCEB1 0.21 19037258