PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Trak2 Hgs 17062640 biogrid exp G G G G G G G G Snap23 Hgs 10825299,10510169 biogrid exp G G G G G G G G Syp Hgs 10825299 biogrid exp G G G G G G G G Stx1a Hgs 10825299 biogrid exp G G G G Ntrk2 Hgs 19351881 biogrid exp, ortho G G G Snap25 Hgs 10825299,10510169 biogrid,i2d,mint,intact exp, ortho G G G G G Ubc Hgs 22871113 biogrid exp, ortho Hap1 Hgs 12021262 intact exp, ortho G G G G G G G G Tmem189 Hgs ortho HLA-B associated transcript 8, rat orthologue, Protein Ehmt2 Hgs ortho G G G G G G G G Hnrnpk Hgs ortho Lymphotoxin B receptor, Lymphotoxin beta receptor (TNFR superfamily, member 3), Protein Ltbr Hgs ortho G G G G G G G G Krt31 Hgs ortho Tfrc Hgs ortho G G G G G G G G Gga3_predicted Hgs ortho G G G G G G G Protein Cstf2t, RCG47773 Hgs ortho Hgs Ubqln1 ortho G G G G G G G G Ywhab Hgs ortho G G G G G G G G Met Hgs ortho G LOC361120 Hgs ortho Nmi Hgs ortho Gfap Hgs ortho G G G G G G Hgs Hgs ortho G G G G G G G G Trim3 Hgs ortho G G G G G G G G Il4r Hgs ortho G Golgi associated, gamma adaptin ear containing, ARF binding protein 1, Protein Gga1 Hgs ortho G G G G G G G G Tsg101 Hgs ortho G G G G G G G G Protein Snx7, RCG28719, Sorting nexin 7 Hgs ortho Hgs Smad5 ortho G G G G G Timmdc1 Hgs ortho G G G G G G G G Pik3r1 Hgs ortho G Tmem17 Hgs ortho Hgs Myo5a ortho G G G G G G G G Laptm4b Hgs ortho G G G G G G G G Nfkbia Hgs ortho G G G G G Smo Hgs ortho Pld3 Hgs ortho G G G G G G G G Protein Fjx1, RCG27341 Hgs ortho App Hgs ortho G G G G G G G G Ushbp1 Hgs ortho Pak1 Hgs ortho G G G G G G G G Ahcyl1_predicted Hgs ortho G G G G G G G G Insr Hgs ortho G G G G G G G G Smc6l1_predicted Hgs ortho Aes Hgs ortho G G G G G G G G Flna_predicted Hgs ortho G G G G G G G Tom1l1 Hgs ortho Begain Hgs ortho G G G G G G G G Adrb2 Hgs ortho G Rab4a Hgs ortho G G G G G G G Ccdc33 Hgs ortho Slk Hgs ortho Lurap1 Hgs ortho Smad3 Hgs ortho G G G Protein Vps37a, Similar to DNA segment, Chr 8, ERATO Doi 531, expressed, isoform CRA_c, Vacuolar protein sorting 37 homolog A (S. cerevisiae) Hgs ortho G G G Fbxo11 Hgs ortho G G G G G G G G RGD1563141_predicted Hgs ortho G G G G G G G G Golt1b protein, Protein Golt1b Hgs ortho Wnk1 Hgs ortho G G G G G G G G Dlg4 Hgs ortho G G G G G G Ubqln4_predicted Hgs ortho G G G G G G G G Hgs Ilkap ortho G G G G G G G G Hadha Hgs ortho G G G G G G G G Mthfd1l protein, Protein Mthfd1l Hgs ortho Pfkm Hgs ortho G G G G G G G G Nup54 Hgs ortho G G G G G G G Fibroblast growth factor receptor Hgs ortho G G G G G G G G Stx12 Hgs ortho G G G G G G G G Krt19 Hgs ortho G ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1, Protein Atp6v0d1, RCG51062, isoform CRA_a Hgs ortho G G G G G G G G Pax6 Hgs ortho G G G G Krt40 Hgs ortho Sh3kbp1 Hgs ortho G G G G G G G G Mknk1 Hgs ortho G G G G G G G G Snx1 Hgs ortho G G G G G G G G Nup205_predicted Hgs ortho G G G G G G G G Tada2a Hgs ortho G G G G Jag1 Hgs ortho G Cdk2 Hgs ortho Ndc80 Hgs ortho Protein Ints4 Hgs ortho G G G G G G G G Baculoviral IAP repeat-containing 2, Protein Birc2 Hgs ortho G G G G G G G G Rab7a Hgs ortho G G G G G G G G Pelp1 Hgs ortho G G G G G G G G Cd4 Hgs ortho G G G G G G G Smad1 Hgs ortho G G G G G G G G Atp2a2 Hgs ortho G G G G G G G G Il2rb Hgs ortho G G G G Krt18 Hgs ortho G G G G G G Protein Ppp1r16a Hgs ortho G Ap2m1 Hgs ortho G G G G G G G G Protein Tbc1d15, TBC1 domain family, member 15 Hgs ortho Nedd8 Hgs ortho G G G G G G G G Protein Armc8 Hgs ortho RGD1311455_predicted Hgs ortho G G G G Arrb2 Hgs ortho G G G G G Anxa6 Hgs ortho G G G G G G G G Protein Rangrf, RCG35454 Hgs ortho G G G G G G G G Protein Atxn1l Hgs ortho Hgs Tlr4 ortho G Hspa8 Hgs ortho Bcas2_predicted Hgs ortho G G G G G G G G Actinin alpha 3, isoform CRA_a, Protein Actn3, Skeletal muscle-specific alpha-actinin 3 Hgs ortho G Grb2 Hgs ortho G G G G G G G G Cog7 Hgs ortho Protein Snx2, Sorting nexin 2 Hgs ortho G G G G G G G G Gfi1b_predicted Hgs ortho Protein Sf3b3 Hgs ortho G G G G G G G G Decr1 Hgs ortho G G G G G G G G Pogz_predicted Hgs ortho G G G G G G G Map3k7 Hgs ortho Arrdc3 Hgs ortho Notch1 Hgs ortho G G G G G G G Repin1 Hgs ortho Scnn1a Hgs ortho G G Il6st Hgs ortho G G G G G G G RGD1562370_predicted Hgs ortho Rab14 Hgs ortho G G G G G G G G Crmp1 Hgs ortho G G G G G Stam2 Hgs ortho Tfip11 Hgs ortho G G G G G G G G Il2ra Hgs ortho Ccdc114 Hgs ortho Ap2a2 Hgs ortho G G G G G G G G Cep57l1 Hgs ortho Protein Snx12 Hgs ortho G G G G G G G G Protein Mov10, RCG51996 Hgs ortho G G G G G Cog4_predicted Hgs ortho G G G G G G G G Stxbp1 Hgs ortho G G G G G G G G Litaf Hgs ortho G G G G G G G G Vps4a Hgs ortho G G G G G G G G Rab5a Hgs ortho G G G G G G G G Vps35_mapped Hgs ortho G G G G G G G G Krt15 Hgs ortho G G Cstf2 Hgs ortho Exoc7 Hgs ortho Vamp2 Hgs ortho G G G G G G G G Smad2 Hgs ortho G G G G G G G G Hgs Lyst ortho Golgi associated, gamma adaptin ear containing, ARF binding protein 2, isoform CRA_a, Protein Gga2 Hgs ortho G G G G G G G G Pef1 Hgs ortho G G G G G G G G Sumo1 Hgs ortho G G G G G G G G Gkap1 Hgs ortho G G G G G G G Hgs Actn4 ortho G G G G G G G G Sec23a_predicted Hgs ortho Apc Hgs ortho Vmp1 Hgs ortho G G G G G G G G Brinp3 Hgs ortho Avpr2 Hgs ortho G G G G Ube2i Hgs ortho G G G G G G G G Cltc Hgs ortho G G G G G G G G Nf2 Hgs ortho G G G G G G G G Protein Spry2, Sprouty homolog 2 (Drosophila) Hgs ortho G G G G LOC687208 protein, Protein Vps37d, RCG21373, isoform CRA_a Hgs ortho Gja1 Hgs ortho G G G G G G G G Protein Tom1, Target of myb1 homolog (Chicken) Hgs ortho G G G G G G G G Rab11a Hgs ortho G G G G G G G G Ugdh Hgs ortho G G G G G G G G Ube2n Hgs ortho G G G G G G G G Abca1 Hgs ortho Cep55 Hgs ortho Ptprs Hgs ortho G G G G G G G G Snx3 Hgs ortho G G G G G G G G Exoc8 Hgs ortho Tubb5 Hgs ortho G G G G G G G G Ppp1r7 Hgs ortho G G G G G G G G LOC685144 protein, Protein Sec24c, RCG41932 Hgs ortho G G G G G G G G Farp2_predicted Hgs ortho G G G G G G G G Arrb1 Hgs ortho Ctbp2 Hgs ortho G G G G G G G G Usp34 Hgs ortho G G G G G G G G Mif4gd Hgs ortho G G G G G G G G Trap1 Hgs ortho G G G G G G G G Serine hydroxymethyltransferase Hgs ortho G G G G Ap1b1 Hgs ortho G G G G G G G G RGD1307844_predicted Hgs ortho G G G G G G G G P4ha3 Hgs ortho Ocln Hgs ortho G G G G G G G Meis1 protein, Protein Meis1 Hgs ortho Hgh1 Hgs ortho G G G G G G G G Osbpl3 Hgs ortho G G G G G G G G Scrn1 Hgs ortho Abi2 Hgs ortho G G G G G G G G Esrrg Hgs ortho Protein Mark4 Hgs ortho G G G G G G G G Cttnbp2nl_predicted Hgs ortho Acly Hgs ortho G G G G G G G G Mat2a Hgs ortho G G G G G G G G Protein Trio Hgs ortho G G G G G G G Eps15 Hgs ortho G G G G G G G G Urod Hgs ortho G G G G G G G G Protein Tjp2, Tight junction protein 2 Hgs ortho G G G G G G Dctn2 Hgs ortho G G G G G G G G Protein Cit Hgs ortho G G G G G G G G Bsg Hgs ortho G G G G G G G G Protein Scamp3 Hgs ortho G G G G G G G G Smad4 Hgs ortho G G G G G G G G Tubb2a Hgs ortho G G G G G G G G Protein Sf3a3, Splicing factor 3a, subunit 3 Hgs ortho G G G G G G G G Cask Hgs ortho Nxf1 Hgs ortho G G G G G G G G Mest Hgs ortho G G G G G Napa Hgs ortho G G G G G G G G LOC100911235 Hgs ortho G G G G G G G G Hgs Itsn1 ortho LOC293551 Hgs ortho G G G G G G G G Ntrk1 Hgs ortho Sptbn1 Hgs ortho G G G G G G G G Mapk8 Hgs ortho G G G G G G G G Protein Npas2 Hgs ortho Arfip2 Hgs ortho G G G G G G G G Pcdhgc5 Hgs ortho Itch Hgs ortho Uba1 Hgs ortho G G G G G G G G Vegfa Hgs ortho G G G G G G G G Protein Stam, RCG55706, Signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 Hgs ortho Atp1a1 Hgs ortho G G G G G G G G Pitx1 Hgs ortho G RGD1561880_predicted Hgs ortho G G G G G G G G Rhobtb3_predicted Hgs ortho G G Scnn1b Hgs ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P60881 Q9JJ50 - 10825299 - X 2 P60881 Q9JJ50 affinity chromatography technology 10510169 physical association X 2 P60881 Q9JJ50 two hybrid 10825299 direct interaction X 2 P60881 Q9JJ50 affinity chromatography technology 10825299 physical association X 2 P32851 Q9JJ50 affinity chromatography technology 10825299 physical association X 2 Q63429 Q9JJ50 affinity chromatography technology 22871113 physical association X 2 O70377 Q9JJ50 affinity chromatography technology 10510169 physical association X 2 O70377 Q9JJ50 two hybrid 10825299 direct interaction X 2 Q9JJ50 affinity chromatography technology 19351881 physical association X 2 P07825 Q9JJ50 biochemical 10825299 colocalization X 2 Q8R2H7 Q9JJ50 affinity chromatography technology 17062640 physical association X 2 Q8R2H7 Q9JJ50 affinity chromatography technology 17062640 physical association X 2 Q9JJ50 affinity chromatography technology 12847087 association C 4 Q9JJ50 pull down 12021262 association C 3 Q9JJ50 cosedimentation through density gradient 12021262 colocalization C 3 P60881 Q9JJ50 pull down 10825299 direct interaction X 2 P60881 Q9JJ50 two hybrid 10825299 physical association X 2 P54256 Q9JJ50 pull down 12021262 direct interaction X 2 P54256 Q9JJ50 two hybrid 12021262 physical association X 2 P54256 Q9JJ50 anti bait coimmunoprecipitation 12021262 physical association X 2 P54256 Q9JJ50 confocal microscopy 12021262 colocalization X 2 P54256 Q9JJ50 two hybrid 12021262 physical association X 2 P42566 Q9JJ50 coimmunoprecipitation 10514494 physical association X 2 P42566 Q9JJ50 two hybrid 10514494 physical association X 2 P42566 Q9JJ50 pull down 10514494 direct interaction X 2 P42566 Q9JJ50 coimmunoprecipitation 10809762 physical association X 2 P42566 Q9JJ50 two hybrid 10809762 physical association X 2 Q9JJ50 P54256-2 pull down 12021262 direct interaction X 2 Q9JJ50 P54256-2 confocal microscopy 12021262 colocalization X 2 Q9JJ50 P54256-2 confocal microscopy 12021262 colocalization X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JJ50 Q63604 HGS NTRK2 0.21 19351881 Q9JJ50 Q8R2H7 HGS TRAK2 0.376 17062640 Q9JJ50 Q63429 HGS UBC 0.126 22871113 Q9JJ50 P07825 HGS SYP 0.126 10825299 Q9JJ50 P60881 HGS SNAP25 0.794 10825299,10510169 Q9JJ50 O70377 HGS SNAP23 0.454 10825299,10510169 Q9JJ50 P42566 HGS EPS15 0.794 10514494,10809762 Q9JJ50 P32851 HGS STX1A 0.21 10825299