PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Slc2a4 Gnb2l1 16396496 intact exp G G G Mapk3 Gnb2l1 19935650 mint,intact exp G G G G G G G Stx1a Gnb2l1 i2d exp G G G G Tollip Gnb2l1 19198660 biogrid exp G G G G G G G G Gnb2l1 Sumo3 22082260 biogrid exp G G G G G G G G Gnb2l1 Grin2b i2d exp, ortho G G Gnb2l1 Fyn i2d exp, ortho G G G G G Gnb2l1 Ubc 22871113 biogrid exp, ortho Gnb2l1 Slc9a3r1 ortho G G G G G G G G Abcc3 Gnb2l1 ortho Ube2t_predicted Gnb2l1 ortho G Gnb2l1 Vcl ortho G G G G G G G G Gnb2l1 Eif3g ortho G G G G G G G G Prkce Gnb2l1 ortho G G G G G G G G Gnb2l1 Grap2 ortho Plec Gnb2l1 ortho G G G G G G G G Gnb2l1 Sbds ortho G G G G G G G G Gnb2l1 Pan2 ortho G G G G G G G G Protein Lrp12 Gnb2l1 ortho G G G G G G G G Protein Thoc2 Gnb2l1 ortho Gnb2l1 Prkab2 ortho Gnb2l1 Psmd2 ortho G G G G G G G G Esr1 Gnb2l1 ortho Gnb2l1 Src ortho G G G G G Pik3cd_predicted Gnb2l1 ortho G Agtr1 Gnb2l1 ortho G G G G Hspa4 Gnb2l1 ortho G G G G G G G G Ntrk1 Gnb2l1 ortho Gnb2l1 Met ortho G Gnb2l1 Cdh1 ortho G G G G Rpl5 Gnb2l1 ortho Irs1 Gnb2l1 ortho Gnb2l1 Fubp1 ortho Gnb2l1 Cct2 ortho G G G G G G G G Vcam1 Gnb2l1 ortho Gnb2l1 Csf2rb ortho G G G Gnb2l1 Srek1 ortho G G G G Gnb2l1 Eif6 ortho G G G G G G G G Gnb2l1 Rpl19 ortho G G G G G G G G Psma2 Gnb2l1 ortho G G G G G G G G Usp34 Gnb2l1 ortho G G G G G G G G Gabrb3 Gnb2l1 ortho Eif3c Gnb2l1 ortho G G G G G G G G Gnb2l1 Pxn ortho G G G G G G G G Ifnar1_predicted Gnb2l1 ortho G Gnb2l1 Lrwd1 ortho G G G G G G G G Ccdc58_predicted Gnb2l1 ortho G G G G G G G G Cul3 Gnb2l1 ortho G G G G G G G G Rpl27a Gnb2l1 ortho G G G G G G G G Gnb2l1 Rps27 ortho Protein Lrrk2 Gnb2l1 ortho Kcnab1 Gnb2l1 ortho G G G G G G G G Gnb2l1 Glyr1 ortho G G G G G G G G Protein Ruvbl2, RuvB-like 2 (E. coli) Gnb2l1 ortho G G G G G G G G Gnb2l1 Pias2 ortho G G G G G G G G Hrb2 Gnb2l1 ortho G G G G G G G G Rps21 Gnb2l1 ortho Gnb2l1 Fbxo6 ortho G G G G G G G G Fbxw2 Gnb2l1 ortho Gnb2l1 Ccbl2 ortho G G G G G G G Itgb1 Gnb2l1 ortho G G G G G G G G Aldoa Gnb2l1 ortho G G G G G G G G Ywhae Gnb2l1 ortho G G G G G G G G H2afv Gnb2l1 ortho G G G G G G Actb Gnb2l1 ortho Protein Pwp2 Gnb2l1 ortho Rps2 Gnb2l1 ortho Npm1 Gnb2l1 ortho Rpl23a Gnb2l1 ortho G G G G G G G G Brca1 Gnb2l1 ortho G Rb1 Gnb2l1 ortho G G G G G G Gnb2l1 Yars ortho G G G G G G G G Syt1 Gnb2l1 ortho Fem1b Gnb2l1 ortho Gnb2l1 Syn2 ortho G G G G Protein Unk Gnb2l1 ortho G Gnb2l1 Protein Ppp2r1a, Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a, Protein phosphatase 2 (Formerly 2A), regulatory subunit A, alpha isoform ortho G G G G G G G G Mapk8 Gnb2l1 ortho G G G G G G G G Gnb2l1 Rpl10 ortho Gnb2l1 Hnrnph2 ortho Tbxa2r Gnb2l1 ortho G Ywhaz Gnb2l1 ortho G G G G G G G G Gnb2l1 Shc1 ortho Gnb2l1 Grpel1 ortho G G G G G G G G Gnb2l1 Nob1 ortho G G G G G G G G Gnb2l1 Pir ortho Gnb2l1 Sgtb ortho Tnf Gnb2l1 ortho Rpl15 Gnb2l1 ortho Cul2_predicted Gnb2l1 ortho G G G G G Protein LOC100910486, Solute carrier family 27 (Fatty acid transporter), member 6 (Predicted) Gnb2l1 ortho Acat1 Gnb2l1 ortho G G G G G G G G Gnb2l1 Rnf2 ortho Stk3 Gnb2l1 ortho G G G G G Gnb2l1 Pgls ortho G G G G G G G G Gnb2l1 Xpo1 ortho G G G G G G G G Rplp0 Gnb2l1 ortho G G G G G G G G Ache Gnb2l1 ortho Gnb2l1 Baculoviral IAP repeat-containing 2, Protein Birc2 ortho G G G G G G G G Gnb2l1 Neural cell expressed, developmentally down-regulated 9, Protein Nedd9, RCG44232, isoform CRA_b ortho G G G G G G G G Gnb2l1 Ddx19b ortho Gnb2l1 Desi1 ortho Map3k4_predicted Gnb2l1 ortho Receptor protein serine/threonine kinase Gnb2l1 ortho Fbl Gnb2l1 ortho G G G G G G G G Gnb2l1 Hsp90b1 ortho G G G G G G G G Gnb2l1 Rasa3 ortho G G G G G Got1 Gnb2l1 ortho G G G G G G G G Slc4a2 Gnb2l1 ortho G G G G G G G G Jun Gnb2l1 ortho G G G G G G G G Gnb2l1 Cb1-727, Platelet-derived growth factor subunit A ortho G G G G G G G G Gnb2l1 Cdk2 ortho Gnb2l1 Ptprs ortho G G G G G G G G Gnb2l1 Prkcb ortho G G G G G G G Gnb2l1 Pag1 ortho Gnb2l1 Dnajc2 ortho G G G G G G Rps5 Gnb2l1 ortho G G G G G G G G Gnb2l1 St7 ortho Gnb2l1 Rnf185 ortho G G G G G Gnb2l1 Ikbkb ortho G G G G G G G G Gnb2l1 Mdc1 ortho G Cct8_predicted Gnb2l1 ortho G G G G G G G G Protein Nat10, RCG26113, isoform CRA_d Gnb2l1 ortho G G G Aurkb Gnb2l1 ortho G G G G Gnb2l1 Interferon activated gene 204, Protein Mnda ortho Gnb2l1 Nol10 ortho Tyrosine-protein kinase Gnb2l1 ortho G G G G Mapk9 Gnb2l1 ortho G G Gnb2l1 Lyn ortho G G G G Gnb2l1 Csnk1d ortho G G G G G G G G Mapk6 Gnb2l1 ortho G G G G G G G G Ptpn11 Gnb2l1 ortho G G G G G G G G Protein Wipi1, Wipi1 protein Gnb2l1 ortho G G G G G G G Ptn Gnb2l1 ortho G G G G G G Protein Ercc2, RCG54110 Gnb2l1 ortho G G G Gnb2l1 Chromobox homolog 8 (Drosophila, Pc class), isoform CRA_a, Chromobox homolog 8 (Pc class homolog, Drosophila), Protein Cbx8 ortho G Protein Ddx6, RCG58047 Gnb2l1 ortho G G G G G G G Protein Irs2, RCG43183 Gnb2l1 ortho G G G G G G G G Gnb2l1 Protein Zfp819, Similar to RIKEN cDNA 4933405K07, Zinc finger protein 819 ortho Gnb2l1 DnaJ (Hsp40) homolog, subfamily A, member 4, Protein Dnaja4 ortho G G G G G G G G Prkar2a Gnb2l1 ortho G G G G G G G G Gnb2l1 Eif3b ortho G G G G G G G G Rps9 Gnb2l1 ortho Rpl7 Gnb2l1 ortho G G G G G G G G Gnb2l1 Anxa2 ortho G G G G G G G G Adrb2 Gnb2l1 ortho G Trim45_predicted Gnb2l1 ortho Denr Gnb2l1 ortho G G G G G G G G Hspa9 Gnb2l1 ortho Habp4_predicted Gnb2l1 ortho G G G G G G G G Gnb2l1 Vhl ortho G G G G G G G G Slc6a3 Gnb2l1 ortho G G G G G Ak2 Gnb2l1 ortho G G G G G G G G Gnb2l1 Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14, Protein Psmd14, Psmd14 protein, RCG26455, isoform CRA_b ortho Gnb2l1 Prkd1 ortho Rpl4 Gnb2l1 ortho G G G G G G G G Protein Atl2 Gnb2l1 ortho G G G G G G G G Cish Gnb2l1 ortho Protein Tln1, RCG55135, isoform CRA_b Gnb2l1 ortho G G G G G G G G Insr Gnb2l1 ortho G G G G G G G G Gnb2l1 Tp63 ortho Gnb2l1 Cyclin-dependent kinase inhibitor 1A, Cyclin-dependent kinase inhibitor 1A (P21, Cip1), P21, P21 protein, Protein Cdkn1a ortho G G G G G G G RGD1307179_predicted Gnb2l1 ortho G1p2_predicted Gnb2l1 ortho Integrin beta Gnb2l1 ortho G G G Htt Gnb2l1 ortho G G G G G G G Rps3 Gnb2l1 ortho G G G G G G G G Gnb1 Gnb2l1 ortho G G G G G G G G Psmb2 Gnb2l1 ortho G G G G G G G G Chuk_predicted Gnb2l1 ortho G G G G G G G G Nr3c1 Gnb2l1 ortho G G G G G G G G Rpl37a Gnb2l1 ortho Kinesin-like protein Gnb2l1 ortho G Park7 Gnb2l1 ortho G G G G G G G G Rps27l Gnb2l1 ortho G G Gnb2l1 Hdac1 ortho G G Igf1r Gnb2l1 ortho G G G G G G G G Rab7a Gnb2l1 ortho G G G G G G G G Eef1a1 Gnb2l1 ortho G G G G G G G G Gnb2l1 Ywhah ortho G G G G G G G G Elavl4 Gnb2l1 ortho G G G G G G G G Protein Pbx1 Gnb2l1 ortho Protein Helz Gnb2l1 ortho G G G G G G G G Gnb2l1 Mid1 ortho Tnfrsf1a Gnb2l1 ortho G G G G G G G G Gnb2l1 Hsd17b4 ortho G G G G G G G G Gnb2l1 Cd81 ortho G G G G G G G G Rpsa Gnb2l1 ortho Pak1 Gnb2l1 ortho G G G G G G G G Eif3s12_predicted Gnb2l1 ortho G G G G G G G G Pts Gnb2l1 ortho G G G G G G G Rps20 Gnb2l1 ortho Pde4d Gnb2l1 ortho G G G G G G Gnb2l1 Poly(RC) binding protein 2, Protein Pcbp2 ortho G G G G G G G G Gnb2l1 Tubb5 ortho G G G G G G G G Gnb2l1 Bysl ortho G G G G G G G G Arf4 Gnb2l1 ortho G G G G G G G G Gnb2l1 Nsmaf ortho G G G G G G G G Rhoa Gnb2l1 ortho G G G G G G G G DEAH (Asp-Glu-Ala-His) box polypeptide 15 (Predicted), isoform CRA_b, Protein Dhx15 Gnb2l1 ortho Rpl21 Gnb2l1 ortho Ubl4a Gnb2l1 ortho G G G G G G G G Gnb2l1 Lias ortho G G G G G G G G Cftr Gnb2l1 ortho Riok3_predicted Gnb2l1 ortho Ttyh3_predicted Gnb2l1 ortho G G G G G G G G LOC312299 Gnb2l1 ortho G Lsm1_predicted Gnb2l1 ortho Gnb2l1 Coronin ortho G G G G G G G G Cul1_predicted Gnb2l1 ortho G G G G G G G G Acetyl-coenzyme A synthetase Gnb2l1 ortho G G G G G G Cyp3a2 Gnb2l1 ortho G Gnb2l1 Ptov1 ortho G G G G G G G Hsd3b7 Gnb2l1 ortho G G G G G G G G Hif1a Gnb2l1 ortho G G G G G G G G Atp6v1b2 Gnb2l1 ortho G G G G G G G G Gnb2l1 Eif3a ortho G G G G G G G G Gnb2l1 Wdr83 ortho Gnb2l1 COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 ortho G G G G G G G G Gnb2l1 Mapkap1 ortho G G G G G G G Gnb2l1 Pabpc1 ortho G G G G G G G G Bcl2l11 Gnb2l1 ortho Mtor Gnb2l1 ortho G G G G G G G G Gnb2l1 Rad17 ortho RGD1309441_predicted Gnb2l1 ortho G G G G G G G G Rps25 Gnb2l1 ortho Gnb2l1 Gnb2l1 ortho G G G G G G G G Cherp_predicted Gnb2l1 ortho G G G G G G G G Gnb2l1 Ago2 ortho G G G G G G G Sirt7 Gnb2l1 ortho G G G G G G G G Gnb2l1 Ccna1 ortho Elovl4_predicted Gnb2l1 ortho G G G G G G G G Gnb2l1 Ak6 ortho Gnb2l1 Yipf5 ortho G G G G G G G G Smpd3 Gnb2l1 ortho G G G G G G G Pcgf4_predicted Gnb2l1 ortho Hist1h4b, Hist1h4m, Hist4h4 Gnb2l1 ortho G G G G G Gnb2l1 Agtrap ortho G G G G G Gnb2l1 Sodium-coupled neutral amino acid transporter 1, Spermidine/spermine N1-acetyl transferase (Mapped), isoform CRA_c, Spermidine/spermine N1-acetyl transferase 1 ortho G G G G G G G G Gnb2l1 Acta1 ortho G G G G G Dynll1 Gnb2l1 ortho Rasa1 Gnb2l1 ortho G G G G G G G Antisecretory factor, Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 4, isoform CRA_a, Protein Psmd4 Gnb2l1 ortho G G G G G G G G Dnm1 Gnb2l1 ortho G G G G G G G G Gnb2l1 Nol5a ortho G G G G G G G G Gnb2l1 Dctn2 ortho G G G G G G G G Protein Pacs2 Gnb2l1 ortho Gnb2l1 Dync1li2 ortho G G G G G G G G Trp73_predicted Gnb2l1 ortho Prpf31_predicted Gnb2l1 ortho Grin1 Gnb2l1 ortho G G G G Hnrnpa1 Gnb2l1 ortho G G G G G G G Ar Gnb2l1 ortho G G G G G G G Gnb2l1 Eif3e ortho Gnb2l1 Nfkb1 ortho G G G G G G G G Rps8 Gnb2l1 ortho G G G G G G G G Rps16 Gnb2l1 ortho G G G G G G G G Kcna5 Gnb2l1 ortho G Obsl1 Gnb2l1 ortho Gnb2l1 DiGeorge syndrome critical region gene 14, DiGeorge syndrome critical region gene 14 homolog (Human), Protein Dgcr14 ortho Rpl13 Gnb2l1 ortho Il2rb Gnb2l1 ortho G G G G Gnb2l1 Stau1 ortho G G G G G G G G Eed_predicted Gnb2l1 ortho G G G G G G G G Gnb2l1 Makorin, ring finger protein, 2, Protein Mkrn2 ortho G G G G G G G G LOC100360914 Gnb2l1 ortho Protein Sfn, RCG31390 Gnb2l1 ortho Gnb2l1 Cct3 ortho G G G G G G G G Plcg1 Gnb2l1 ortho G G G G G G G G Gnb2l1 Tial1_mapped ortho G G G G G G G G RGD1311099_predicted Gnb2l1 ortho Il7r_predicted Gnb2l1 ortho Stat3 Gnb2l1 ortho G G G G G G G G Gnb2l1 Ik ortho G G G G G G G G Prkcd Gnb2l1 ortho G G G G G G G G Stip1 Gnb2l1 ortho G G G G G G G G Gnb2l1 Esr2 ortho Gnb2l1 Rps12 ortho Gnb2l1 Psmc3 ortho G G G G G G G G Gnb2l1 Ikbkg ortho Gnb2l1 Tpp2 ortho G G G G G G G G Gnb2l1 Epor ortho G G G G G G G Gnb2l1 Cand1 ortho G G G G G G G G Gnb2l1 Il4r ortho G Rpl7a Gnb2l1 ortho Protein Zcchc3, RCG37285 Gnb2l1 ortho G G G G G G G G Bag2 Gnb2l1 ortho G G G G G G G DNA-directed RNA polymerase Gnb2l1 ortho G G G G G G G G Gnb2l1 Naa11 ortho Ncam1 Gnb2l1 ortho G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q63429 P63245 affinity chromatography technology 22871113 physical association X 2 P63245 A2RUW1 two hybrid 19198660 direct interaction X 2 P63245 Q5XIF4 affinity chromatography technology 22082260 physical association X 2 P63245 anti bait coimmunoprecipitation 12388589 association C 4 P21708 P63245 anti bait coimmunoprecipitation 19935650 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Gnb2l1 Tollip MI:0018(two hybrid) 19198660 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335232 prey bait Gnb2l1 Ubc MI:0004(affinity chromatography technology) 22871113 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336437 prey bait Gnb2l1 Sumo3 MI:0004(affinity chromatography technology) 22082260 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334265 prey bait Mapk3 Gnb2l1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19935650 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0914(association)|MI:0914(association) (intact)|MI:0471(mint) UniProt_185469|MINT_71312 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality TOLLIP RACK1 19198660 0018 LC STX1A RACK1 15202772 0019 LC RACK1 GRIN2B 11943848,11943848,11943848,11943848 0405,0018,0047,0019 LC RACK1 FYN 11943848,11943848,11943848 0018,0047,0019 LC SLC2A4 RACK1 16396496 0007 LC MAPK3 RACK1 19935650 0006 LC RACK1 SUMO3 22082260 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5XIF4 P63245 SUMO3 GNB2L1 0.126 22082260 Q63429 P63245 UBC GNB2L1 0.126 22871113 P63245 A2RUW1 GNB2L1 TOLLIP 0.309 19198660 P63245 P19357 GNB2L1 SLC2A4 0.126 16396496 P63245 P21708 GNB2L1 MAPK3 0.126 19935650