PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sh3gl1 Synj2 i2d exp Sorbs2 Sh3gl1 15659545 biogrid exp G G G G G G Sh3gl1 Ubc 15659545 biogrid exp Sh3gl1 Synj1 9238017 intact exp, ortho G G G G G G Sh3gl1 Dnm1 9238017 intact exp, ortho G G G G G G Sh3gl1 Calr ortho G G G G G G Sh3gl1 Htt ortho G G G G G G Sh3gl1 Thg1l ortho Sh3gl1 Mal2A ortho G G G G G Sh3gl3 Sh3gl1 ortho G G G G Sh3gl1 Sh3kbp1 ortho G G G G G G Sh3gl1 Arpc5 ortho G G G G G G Bag1 Sh3gl1 ortho G G G G G G LOC687750 Sh3gl1 ortho G G G G G Rb1cc1_predicted Sh3gl1 ortho Sh3gl1 Cb1-727, Platelet-derived growth factor subunit A ortho G G G G G G Sh3gl1 Ptprs ortho G G G G G G Sh3gl1 Actr3 ortho Sh3gl1 Ccdc101 ortho G G G Sh3gl1 Aurka ortho G Sh3gl1 Ywhaz ortho G G G G G G Sh3gl1 Khdrbs1 ortho G G G G G G General transcription factor II E, polypeptide 1 (Alpha subunit), Protein Gtf2e1 Sh3gl1 ortho Ptk2 Sh3gl1 ortho G G G G G G Sh3gl1 Crebbp ortho G G G G G Sh3gl1 Mta1 ortho B3gat1 Sh3gl1 ortho G G G G G G Sh3gl1 Lap3 ortho G G G G G Sh3gl1 Ywhae ortho G G G G G G Calu Sh3gl1 ortho G G G G G G Sh3gl2 Sh3gl1 ortho Sh3gl1 Park2 ortho Protein Srgap3 Sh3gl1 ortho Sh3gl1 Nif3l1 ortho Sh3gl1 Pik3r2 ortho G G G G G G Sh3gl1 Axin1 ortho G G G G G G Sept8 Sh3gl1 ortho G G G G G Sh3gl1 Pik3r1 ortho Sh3gl1 Pdcd6ip ortho G G G G G G Sh3gl1 Fubp1 ortho Sh3gl1 Prmt1 ortho Arpc4_predicted Sh3gl1 ortho G G G G G G Sh3gl1 Dpysl4 ortho G G G G G Arpc5l Sh3gl1 ortho G G G G G G Sh3gl1 Vim ortho G G G G G G Sh3gl1 Sh2d4a ortho G G G Sh3gl1 Sh3gl1 ortho G G G G G G Sh3gl1 Aarsd1 ortho G G G G G G LOC102555086 Sh3gl1 ortho G G G G G Sh3gl1 Blnk ortho Dnm1l Sh3gl1 ortho G G G G G Sh3gl1 Actr2 ortho G G G G G G Sh3gl1 Sh3glb1 ortho Sh3gl1 Trmt10a ortho Nsun2_predicted Sh3gl1 ortho G G G G G G Sh3gl1 App ortho G G G G G G Sh3gl1 Gtf2f2 ortho G G G G G G Pfdn1_predicted Sh3gl1 ortho G G G G G G Sh3gl1 Dnm2 ortho G Sh3gl1 Prkaca ortho G G G G G G Sh3gl1 Arpc1a ortho G G G G G G Protein Lrrk2 Sh3gl1 ortho Sh3gl1 Protein Ttc1, Tetratricopeptide repeat domain 1 ortho G G G G G G Protein Gpkow, RCG22908, isoform CRA_a Sh3gl1 ortho Sh3gl1 Kbp ortho G G G G G G Sh3gl1 Dnm3 ortho G G G G G G Pfdn5_predicted Sh3gl1 ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O35964 - 11498538 - X 2 O35964 - 11498538 - X 2 O35964 Q63429 affinity chromatography technology 15659545 physical association X 2 O35964 pull down 15659545 direct interaction X 2 O35964 pull down 9694653 association C 11 O35964 cosedimentation through density gradient 22036569 physical association C 11 O35964 Q62910-2 two hybrid 9238017 physical association X 2 O35964 P21575 far western blotting 9238017 physical association X 2 O35964 Q62910 far western blotting 9238017 physical association X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 fluorescence microscopy 24076656 colocalization X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 pull down 24076656 physical association X 2 O35964 Q70E73 far western blotting 24076656 direct interaction X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2 O35964 Q70E73 peptide array 24076656 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sh3gl1 Dnm1 MI:0018(two hybrid) 9238017 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (intact) UniProt_186459 bait prey Sorbs2 Sh3gl1 MI:0004(affinity chromatography technology) 15659545 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_334650 bait prey Sh3gl1 Ubc MI:0004(affinity chromatography technology) 15659545 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334648 bait prey Sh3gl1 Synj1 MI:0018(two hybrid)|MI:0018(two hybrid) 9238017 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_186460|UniProt_186455 bait|prey prey|null

PPI - HINT Gene A Gene B PMID Method Quality SH3GL1 DNM1 9238017 0047 LC SH3GL1 SYNJ1 9238017,9238017 0047,0018 LC SORBS2 SH3GL1 15659545 0096 LC SH3GL1 UBC 15659545 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O43295 O35964 SRGAP3 SH3GL1 0.454 25819436 O35964 O35413 SH3GL1 SORBS2 0.309 15659545 Q63429 O35964 UBC SH3GL1 0.21 15659545 P50570 O35964 DNM2 SH3GL1 0.21 25471590 P39053 O35964 DNM1 SH3GL1 0.21 25471590 Q9WVS6 O35964 PARK2 SH3GL1 0.21 25471590 P12023 O35964 APP SH3GL1 0.21 22036569 O60260 O35964 PARK2 SH3GL1 0.376 25471590 Q70E73 O35964 RAPH1 SH3GL1 0.671 24076656