PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RGD1562456_predicted CDKI protein long isoform, Cyclin-dependent kinase inhibitor 1C (P57), isoform CRA_b, Protein Cdkn1c 19533683 biogrid exp RGD1562456_predicted Kras 19533683 biogrid exp RGD1562456_predicted Protein Rassf1, Ras association (RalGDS/AF-6) domain family 1, isoform CRA_b, Ras association domain family 1 isoform A 19533683 biogrid exp, ortho LOC100362620 RGD1562456_predicted 19533683 biogrid exp, ortho RGD1562456_predicted p27Kip1 19852587,19533683,17873289 biogrid exp, ortho RGD1562456_predicted Rbl2 19533683 biogrid exp, ortho RGD1562456_predicted Ufd1l ortho Protein Mef2c RGD1562456_predicted ortho RGD1562456_predicted Protein Trpc4ap, Transient receptor potential cation channel, subfamily C, member 4 associated protein, Transient receptor potential cation channel, subfamily C, member 4 associated protein, isoform CRA_a ortho RGD1562456_predicted PTEN/MMAC1 ortho RGD1562456_predicted Sp1 ortho RGD1562456_predicted Bard1 ortho RGD1562456_predicted Ccnb1 ortho RGD1562456_predicted Mybl2_predicted ortho RGD1562456_predicted Usp34 ortho RGD1562456_predicted Smad4 ortho RGD1562456_predicted Akt1 ortho RGD1562456_predicted Esr1 ortho RGD1562456_predicted Ddb1 ortho RGD1562456_predicted Nxf1 ortho RGD1562456_predicted Btg1 ortho RGD1562456_predicted Hspa8 ortho RGD1562456_predicted Protein Cul4a, RGD1563853 protein ortho RGD1562456_predicted Tp53 ortho RGD1562456_predicted Protein Sf3b3 ortho RGD1562456_predicted Pak1 ortho RGD1562456_predicted Cdh1 ortho Fzr1_predicted RGD1562456_predicted ortho RGD1562456_predicted Asb2 ortho RGD1562456_predicted Rad50 ortho RGD1562456_predicted Ccnd1 ortho RGD1562456_predicted Ccng2_predicted ortho RGD1562456_predicted Hsp90aa1 ortho RGD1562456_predicted Nedd8 ortho RGD1562456_predicted Rnd3 ortho Cul1_predicted RGD1562456_predicted ortho RGD1562456_predicted Ccna1 ortho RGD1562456_predicted Uxt ortho RGD1562456_predicted Btg2 ortho RGD1562456_predicted Trim21_predicted ortho RGD1562456_predicted Tcf3 ortho RGD1562456_predicted Dnajb5_predicted ortho RGD1562456_predicted Cdk2 ortho RGD1562456_predicted Nbn ortho RGD1562456_predicted Jak2 ortho RGD1562456_predicted yy1 ortho Sugt1 RGD1562456_predicted ortho RGD1562456_predicted Kpna5 ortho RGD1562456_predicted Wee1 ortho RGD1562456_predicted Protein Rnf126, Ring finger protein 126 ortho RGD1562456_predicted Cacybp ortho RGD1562456_predicted Ywhab ortho RGD1562456_predicted Mef2d ortho RGD1562456_predicted Protein Rag2, RCG27084 ortho RGD1562456_predicted Aarsd1 ortho RGD1562456_predicted Protein Cdc34, RCG29282, isoform CRA_b ortho RGD1562456_predicted Myc ortho RGD1562456_predicted Skp1 ortho RGD1562456_predicted Protein Sirt6, Sirtuin 6 (Silent mating type information regulation 2, homolog) 6 (S. cerevisiae), Sirtuin 6 (Silent mating type information regulation 2, homolog) 6 (S. cerevisiae), isoform CRA_a ortho RGD1562456_predicted Cul2_predicted ortho RGD1562456_predicted Cyclin A2, isoform CRA_b, Protein Ccna2 ortho RGD1562456_predicted Ccne1 ortho RGD1562456_predicted Cops6_predicted ortho RGD1562456_predicted Protein Elf4 ortho RGD1562456_predicted Mta1 ortho RGD1562456_predicted Brca1 ortho RGD1562456_predicted Mlf1_predicted ortho RGD1562456_predicted Impdh2 ortho RGD1562456_predicted Elavl4 ortho RGD1562456_predicted Smad7 ortho RGD1562456_predicted Orc1 ortho RGD1562456_predicted Protein Stub1, STIP1 homology and U-Box containing protein 1, isoform CRA_b ortho RGD1562456_predicted Vhl ortho RGD1562456_predicted Cul5 ortho RGD1562456_predicted Foxo3a_predicted ortho RGD1562456_predicted Hsp90ab1 ortho RGD1562456_predicted Nlk ortho RGD1562456_predicted Btrc ortho RGD1562456_predicted Ppp5c ortho RGD1562456_predicted Pfdn1_predicted ortho RGD1562456_predicted Cdk1 ortho RGD1562456_predicted Spdya ortho RGD1562456_predicted RGD1562456_predicted ortho RGD1562456_predicted Stip1 ortho RGD1562456_predicted Foxo1 ortho RGD1562456_predicted Cyclin-dependent kinase inhibitor 1A, Cyclin-dependent kinase inhibitor 1A (P21, Cip1), P21, P21 protein, Protein Cdkn1a ortho RGD1562456_predicted Ing3 ortho RGD1562456_predicted Chka ortho RGD1562456_predicted Cdc20 ortho RGD1562456_predicted Fkbpl ortho RGD1562456_predicted Mlf2_predicted ortho RGD1562456_predicted Pfdn5_predicted ortho RGD1562456_predicted COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 ortho RGD1562456_predicted Gps1 ortho RGD1562456_predicted Sirt4_predicted ortho RGD1562456_predicted Psmd9 ortho RGD1562456_predicted Ccnd2 ortho RGD1562456_predicted Mre11a ortho RGD1562456_predicted Rb1 ortho RGD1562456_predicted Protein Snrpb2, RCG27500, isoform CRA_c, Small nuclear ribonucleoprotein polypeptide B ortho RGD1562456_predicted Pim1 ortho RGD1562456_predicted Kpna6 ortho RGD1562456_predicted Ar ortho RGD1562456_predicted Dusp1 ortho RGD1562456_predicted Atm_mapped ortho RGD1562456_predicted Gabpa_predicted ortho RGD1562456_predicted E2f1 ortho RGD1562456_predicted Ris2_predicted ortho RGD1562456_predicted Ccnt1_predicted ortho RGD1562456_predicted Cdk9 ortho RGD1562456_predicted Tob1 ortho RGD1562456_predicted Src ortho RGD1562456_predicted Sirt3_predicted ortho RGD1562456_predicted Phb ortho RGD1562456_predicted Cebpa ortho RGD1562456_predicted Rnf7_predicted ortho

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Cdkn1c Skp2 MI:0004(affinity chromatography technology) 19533683 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333952 prey bait M1 Skp2 MI:0004(affinity chromatography technology) 19533683 taxid:363140() taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333955 prey bait Skp2 RGD1561797 MI:0004(affinity chromatography technology) 19533683 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333949 prey bait Rbl2 Skp2 MI:0004(affinity chromatography technology) 19533683 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333953 prey bait Kras Skp2 MI:0004(affinity chromatography technology) 19533683 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333950 prey bait Cdkn1b Skp2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17873289,19533683,19852587 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_334077|BIOGRID_334078|BIOGRID_333708|BIOGRID_333709|BIOGRID_333951 bait|prey|bait|prey|prey prey|bait|prey|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality SKP2 CKS1B 19533683 0004 LC SKP2 CDKN1B 19852587,17873289,19533683 0004,0004,0004 LC SKP2 RBL2 19533683 0004 LC SKP2 KRAS 19533683 0004 LC SKP2 RASSF1 19533683 0004 LC SKP2 CDKN1C 19533683 0004 LC