PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bub1 fzy-RA 20421417,23685359 biogrid,intact exp G G fzy-RA Hey 14605208 biogrid,intact exp fzy-RA CycB3 unassigned4 intact exp G G CG5174-RA fzy-RA 14605208 biogrid,intact exp G G fzy-RA AT23078p i2d exp CG8204-RA fzy-RA 14605208 biogrid,intact exp G G CycA fzy-RA 24019759,unassigned4,22036573 biogrid,intact,dip exp, ortho G G CycB fzy-RA unassigned4 intact exp, ortho G G fzy-RA Mad2, RE72064p 20421417,23685359 biogrid,intact exp, ortho G G fzy-RA cdc16 ortho G G cdc2 fzy-RA ortho G G fzy-RA LD47396p, Tcp-1eta ortho G G fzy-RA Ubiquitin-conjugating enzyme E2 S ortho G G Hsc70-5 fzy-RA ortho G G fzy-RA CG3000-PA, isoform A, GH07620p, RE20929p, Retina aberrant in pattern, isoform B ortho G G Hsc70-3 fzy-RA ortho G G fzy-RA Fbw5, GH09073p ortho G G fzy-RA fzy-RA ortho G G fzy-RA Imaginal discs arrested ortho G G Hsc70Cb, isoform G, Hsc70Cb, isoform H fzy-RA ortho G G fzy-RA HdacX-RA ortho HDAC6, isoform G fzy-RA ortho G G fzy-RA CSN5 ortho G G fzy-RA RuvB-like helicase 2 ortho G G fzy-RA beta-Tub97EF ortho G fzy-RA CG4572-RC ortho G G fzy-RA Apc7 ortho G gammaTub37C fzy-RA ortho G fzy-RA Cdc6 ortho G fzy-RA FI09619p, Mad1, TXBP181-like protein ortho G G fzy-RA Nipped-A ortho G G fzy-RA CG8184, isoform H ortho G G fzy-RA emb ortho G G fzy-RA CG7444 ortho G Receptor protein serine/threonine kinase fzy-RA ortho G G Ras85D fzy-RA ortho G G hyd fzy-RA ortho G G fzy-RA betaTub56D ortho G G fzy-RA Cell division cycle 27 ortholog, isoform A, Cell division cycle 27 ortholog, isoform B, LD12661p ortho G G Plc21C fzy-RA ortho G T-cp1 fzy-RA ortho G G fzy-RA GM12270p, T-complex chaperonin 5, isoform A ortho G G fzy-RA Cks30A ortho G G fzy-RA AT07979p2, Lemming B, isoform A, Lemming B, isoform B, Lemming B, isoform C, Lemming B, isoform D ortho fzy-RA CG9636, isoform C, LD29354p ortho G G RPB3 fzy-RA ortho G G RpS3 fzy-RA ortho fzy-RA l(1)G0022 ortho G G Pka-C1 fzy-RA ortho G fzy-RA Skp2, isoform A, Skp2, isoform E ortho G fzy-RA Rpd3 ortho G polo fzy-RA ortho G G fzy-RA RpA-70 ortho G G fzy-RA APC10 ortho G G cdc2c fzy-RA ortho G fzy-RA Bub3-RA ortho G G fzy-RA T-complex protein 1 subunit delta ortho G G Hsp60 fzy-RA ortho G G Sticky, isoform B fzy-RA ortho G G fzy-RA aurA ortho G G fzy-RA CG10103, isoform A, LD14015p ortho G G fzy-RA Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p ortho G fzy-RA APC4-RA ortho G slmb fzy-RA ortho G fzy-RA CG8258, LD24495p ortho G G fzy-RA Polybromo ortho G 14-3-3epsilon fzy-RA ortho G G RpL23 fzy-RA ortho G G PCNA fzy-RA ortho G G fzy-RA CG9198-PA, isoform A ortho G G fzy-RA vih ortho G G fzy-RA Aats-tyr-m ortho G fzy-RA l(3)psg7 ortho G G fzy-RA Anaphase-promoting complex subunit 2, LD21042p, Morula ortho G G Mtor fzy-RA ortho G G fzy-RA Sirt2 ortho G G fzy-RA CG7033, SD02216p ortho G G Hsc70-1 fzy-RA ortho fzy-RA Eukaryotic translation initiation factor 2A, eIF-2A ortho G G Cctgamma fzy-RA ortho G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A1ZB83 Q24044 - 14605208 - X 2 A1ZA28 Q24044 - 14605208 - X 2 Q7KM13 Q24044 - 14605208 - X 2 A1ZA28 Q24044 two hybrid 14605208 direct interaction X 2 Q24044 P14785-2 pull down 24019759 direct interaction X 2 Q24044 A1Z6I7 affinity chromatography technology 20421417 physical association X 2 Q24044 P14785-2 affinity chromatography technology 22036573 physical association X 2 Q9VRQ2 Q24044 affinity chromatography technology 20421417 physical association X 2 Q7KM13 Q24044 two hybrid 14605208 direct interaction X 2 Q24044 two hybrid 14605208 direct interaction X 2 A1ZB83 Q24044 two hybrid 14605208 physical association X 2 A1ZA28 Q24044 two hybrid 14605208 physical association X 2 Q7KM13 Q24044 two hybrid 14605208 physical association X 2 P14785 Q24044 pull down 24019759 direct interaction X 2 A1ZA28 Q24044 two hybrid 14605208 physical association X 2 Q24044 A1ZB77 two hybrid 14605208 physical association X 2 Q24044 Q9I7I0 experimental interaction detection - physical association X 2 P20439 Q24044 experimental interaction detection - physical association X 2 Q24044 anti bait coimmunoprecipitation 23685359 association C 3 Q24044 anti bait coimmunoprecipitation 23685359 association C 3 Q7KM13 Q24044 two hybrid 14605208 physical association X 2 P14785 Q24044 experimental interaction detection - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B fzy Hey MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip) UniProt_54688|BIOGRID_36181|DIP_8605 prey|prey|- bait|bait|- fzy CycB3 MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45567 unspecified role unspecified role CycA fzy MI:0045(experimental interaction detection)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 22036573,24019759 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_45563|BIOGRID_77139|BIOGRID_72104 unspecified role|bait|bait unspecified role|prey|prey fzy CG5174 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_23223 - - fzy Q9V7D9 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_14998 prey bait fzy Q8MLI4 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_14997 prey bait CycB fzy MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45566 unspecified role unspecified role fzy BubR1 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 20421417,23685359 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact) BIOGRID_64136|UniProt_46770|UniProt_46769 bait|prey|bait prey|bait|prey fzy Q9U9U4 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_23856 prey bait fzy CG5174 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_45696 bait prey fzy CG5174 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_50415 prey bait fzy CG8204 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact) DIP_23224|BIOGRID_45697|UniProt_50416 -|bait|prey -|prey|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q24044 A1ZA28 FZY CG8204-RA 0.183 14605208 Q24044 A1ZB77 FZY A1ZB77 0.183 14605208 Q24044 P14785 FZY CYCA 0.126 unassigned4 Q24044 P20439 FZY CYCB 0.126 unassigned4 Q9VRQ2 Q24044 MAD2 FZY 0.21 23685359 Q9I7I0 Q24044 CYCB3 FZY 0.126 unassigned4 Q7KM13 Q24044 HEY FZY 0.183 14605208 Q24044 A1Z6I7 FZY BUBR1 0.376 23685359