PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Trip1 mts 14605208 biogrid,i2d,mint,intact,dip exp G G G G G G G G G G Trip1 CG14671, isoform A, CG14671, isoform B 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Trip1 E2f2 14605208 biogrid,i2d,mint,intact,dip exp G G G G G G G G G G Trip1 Pixie, isoform A, Pixie, isoform B, RE71924p 17392269 intact exp G G G G G G G G G G Trip1 Dfd 15575970 biogrid,i2d,mint,intact exp Sin3A Trip1 14605208 biogrid,intact exp G G G G G G G G G G Trip1 BM-40, BM-40-SPARC, isoform A, BM-40-SPARC, isoform B, MIP10412p1 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G Trip1 CG4998, isoform B 14605208 biogrid,i2d,mint,intact exp Trip1 Insulator binding factor 2, RE22911p 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G Trip1 CG12256, IP09525p 14605208 i2d,mint,intact exp Trip1 Su(var)3-9 14605208 biogrid exp Trip1 BG5 14605208 biogrid,intact exp G G G G G G G Trip1 eIF3-S10 17392269 intact exp, ortho G G G G G G G G G G Trip1 eIF6 ortho G G G G G G G G G G CG9674, isoform F, CG9674, isoform G Trip1 ortho G G G G G G G G G G PAB-dependent poly(A)-specific ribonuclease subunit PAN2 Trip1 ortho G G G G G G G G G G Trip1 Cullin 3, isoform F, FI19425p1 ortho G G G G G G G G G G Trip1 eIF-2b(epsilon) ortho G G G G G G G G G G Trip1 hyd ortho G G G G G G G G G G Trip1 eRF1 ortho G G G G G G G G G G Tsp86D Trip1 ortho G G G G G G Trip1 Klp61F ortho G G Trip1 bel ortho G G G G G G G G G G Trip1 CHOp24, isoform A, CHOp24, isoform B, GH04989p ortho G G G G G G G G G G Trip1 CG5790-RA ortho G Trip1 RpS5a ortho G G G G G G G G G G Trip1 14-3-3epsilon ortho G G G G G G G G G G Trip1 Tango7 ortho G G G G G G G G G G Trip1 gammaCop ortho G G G G G G G G G G Trip1 dod ortho G G G G Trip1 LD21074p, Programmed cell death 4 ortholog, isoform A, Programmed cell death 4 ortholog, isoform B, Programmed cell death 4 ortholog, isoform C, Programmed cell death 4 ortholog, isoform D ortho G G G G G G G G G G Trip1 GH01161p, TNF-receptor-associated factor 6 ortho G G G G G G G G G Trip1 Eukaryotic translation initiation factor 3 subunit K, eIF3k ortho G G G G G G G G G G Trip1 RpL23a ortho G G G G G G G G G G Trip1 ttm3 ortho G Trip1 eIF-3p66 ortho G G G G G G G G G G Trip1 Kurtz arrestin, Kurtz, isoform A, Kurtz, isoform B, LD31082p ortho G G G Trip1 Protein translation factor SUI1 homolog ortho G G G G G G G G G G Trip1 CG3542, LD24714p ortho G G G G G G Trip1 Nedd4 ortho G G G G G G G G G Trip1 beta'Cop ortho G G G G G G G G G G Trip1 Sce ortho G G G G G G G Trip1 Rpb4 ortho Trip1 His3, His3:CG31613, His3:CG33803, His3:CG33806, His3:CG33809, His3:CG33812, His3:CG33815, His3:CG33818, His3:CG33821, His3:CG33824, His3:CG33827, His3:CG33830, His3:CG33833, His3:CG33836, His3:CG33839, His3:CG33842, His3:CG33845, His3:CG33848, His3:CG33851, His3:CG33854, His3:CG33857, His3:CG33860, His3:CG33863, His3:CG33866 ortho Trip1 RpS13 ortho G G G G G G G G G G Trip1 Raptor, isoform B, Raptor, isoform C ortho Trip1 DnaJ-like-2, isoform A, DnaJ-like-2, isoform B, DnaJ-like-2, isoform C, DnaJ-like-2, isoform D, DnaJ-like-2, isoform E, GM13664p ortho G G G G G G G G G G Trip1 Ergic53, isoform A, Ergic53, isoform B, LD43551p, Rhea ortho G G G G G G G G G G Trip1 Eukaryotic translation initiation factor 3 subunit L, eIF3l ortho G G G G G G G G G G Trip1 Tor ortho G G G G G G G G G G Trip1 eIF3-S5-1 ortho G G G G G G G G G G Trip1 TfIIB ortho G G G G G G G G G G Trip1 BcDNA.GH06451 ortho G G G G G G G G G G Trip1 Trip1 ortho G G G G G G G G G G Trip1 CG17219, FI02048p ortho G G G G Trip1 RpL10 ortho G G G G G G G G G G Trip1 cdc2c ortho G G G Trip1 RpL37A ortho G G G G G G G G G G Trip1 FI11703p, Rad21 mitotic cohesin, Verthandi, isoform A ortho G G G G G G G G G G Trip1 eIF3-S9 ortho G G G G G G G G G G Trip1 CG8184, isoform H ortho G G G G G G G G G G Trip1 Oligosaccharyl transferase 3 ortho G G G G G G G G G G Trip1 Cbp20 ortho G G G G G G G G G G Trip1 Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p ortho G G G G G G G Trip1 CG3756, LP03982p ortho G G G G G G G G G G Trip1 Bx42 ortho G G G G G G G G G G Trip1 grp ortho G G G G G G G G G G eIF3-S8 Trip1 ortho G G G G G G G G G G Trip1 RpL27A ortho G G G G G G G G G G Trip1 emb ortho G G G G G G G G G G Trip1 Sirt7 ortho G G G G G Trip1 CG7728-PA, LD38375p ortho G G G G G G Trip1 Myo61F ortho G G G G G G Trip1 eIF5 ortho G G G G G G G G G G Trip1 eIF3-S6 ortho G G G G G G G G G G Atg18 Trip1 ortho G G G G G G G G G G Trip1 Lig4-RA ortho G G G G G Trip1 Arf51F ortho G G G G G G G G G G Trip1 eIF-3p40 ortho G G G G G G G G G G Trip1 ND-SGDH ortho G G G G G G G G G G Trip1 Adam ortho G G G G G G G G G G Trip1 ran ortho G G G G G G G G G G Trip1 HERC2 ortho G G G G G G G G G G Trip1 Taf5 ortho G G G G G G G G Trip1 eIF-2alpha ortho G G G G G G G G G G Trip1 not ortho G G G G G G G G G G Trip1 RpS20 ortho G G G G G G G G G G Trip1 l(1)G0022 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VHG6 O02195 - 14605208 - X 2 P07548 O02195 - 15575970 - X 2 O02195 Q9VV38 - 14605208 - X 2 A1Z928 O02195 - 14605208 - X 2 O02195 O97365 - 14605208 - X 2 O02195 O77051 - 14605208 - X 2 O02195 Q9VND4 - 14605208 - X 2 O02195 Q7K4Z4 - 14605208 - X 2 O02195 P23696 - 14605208 - X 2 O02195 - 14605208 - X 2 Q9VHG6 O02195 two hybrid 14605208 direct interaction X 2 P07548 O02195 two hybrid 15575970 direct interaction X 2 O02195 two hybrid 14605208 direct interaction X 2 O02195 O77051 two hybrid 14605208 direct interaction X 2 O02195 Q9VGB9 two hybrid 14605208 direct interaction X 2 O02195 Q9VND4 two hybrid 14605208 direct interaction X 2 O02195 Q0E8E2 two hybrid 14605208 direct interaction X 2 O02195 Q7K4Z4 two hybrid 14605208 direct interaction X 2 O02195 O97365 two hybrid 14605208 direct interaction X 2 O02195 P23696 two hybrid 14605208 direct interaction X 2 Q9VHG6 O02195 two hybrid 14605208 physical association X 2 O02195 Q9VV38 two hybrid 14605208 physical association X 2 O02195 Q5U0Y0 two hybrid 14605208 physical association X 2 O02195 O77051 two hybrid 14605208 physical association X 2 O02195 Q9VGB9 two hybrid 14605208 physical association X 2 O02195 Q9VND4 two hybrid 14605208 physical association X 2 O02195 Q7K4Z4 two hybrid 14605208 physical association X 2 O02195 O97365 two hybrid 14605208 physical association X 2 O02195 P23696 two hybrid 14605208 physical association X 2 Q9VHG6 O02195 two hybrid 14605208 physical association X 2 P07548 O02195 two hybrid 15575970 physical association X 2 O02195 tandem affinity purification 17392269 association C 4 O02195 Q9VV38 two hybrid 14605208 physical association X 2 O02195 Q5U0Y0 two hybrid 14605208 physical association X 2 O02195 cosedimentation through density gradient 17392269 association C 7 O02195 O77051 two hybrid 14605208 physical association X 2 O02195 Q9VGB9 two hybrid 14605208 physical association X 2 O02195 Q9VND4 two hybrid 14605208 physical association X 2 O02195 Q7K4Z4 two hybrid 14605208 physical association X 2 O02195 O97365 two hybrid 14605208 physical association X 2 O02195 P23696 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Trip1 CG9740 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0471(mint)|(intact) DIP_26029|BIOGRID_47775|MINT_17678|UniProt_53287 -|bait|prey|prey -|prey|bait|bait Trip1 CG12256 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(intact)|(biogrid)|MI:0471(mint) DIP_10890|UniProt_64912|BIOGRID_37650|MINT_25971 -|prey|prey|prey -|bait|bait|bait Trip1 Q9V8H5 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_16180 prey bait Trip1 mts MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact)|MI:0471(mint) DIP_25357|BIOGRID_47277|UniProt_63267|MINT_17013 -|prey|prey|prey -|bait|bait|bait Trip1 Sin3A MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_26008 - - Trip1 Sin3A MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_47759 prey bait Trip1 BM-40-SPARC MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip)|MI:0471(mint) UniProt_62829|BIOGRID_46949|DIP_24929|MINT_16594 prey|prey|-|prey bait|bait|-|bait Trip1 Sin3A MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_53266 prey bait Trip1 Q8ML45 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_17658 prey bait Trip1 Dfd MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_39991|MINT_20729|BIOGRID_58633 bait|bait|bait prey|prey|prey Trip1 imd MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip) BIOGRID_46631|UniProt_62364|DIP_24474 prey|prey|- bait|bait|- Trip1 CG4998 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0465(dip)|(intact) MINT_15680|BIOGRID_46267|DIP_23949|UniProt_61830 prey|prey|-|prey bait|bait|-|bait Trip1 E2f2 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_7481|MINT_22824|BIOGRID_35347|UniProt_53555 -|prey|prey|prey -|bait|bait|bait Trip1 CG14671 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip)|(biogrid)|(intact) MINT_29837|DIP_15034|BIOGRID_40288|UniProt_48325 prey|-|prey|prey bait|-|bait|bait