PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus cdc2 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p 15575970 biogrid,i2d,mint,intact exp G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p CG32672-PA, LD05816p ortho G G G G G G G G G G alc-RA Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p CG17219, FI02048p ortho G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p CSN5 ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p CG3436, isoform A, CG3436, isoform C, GM13767p ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p Mad2, RE72064p ortho G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p Probable dimethyladenosine transferase ortho G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p wds ortho G G G G G G G G RpS3 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p pit ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p AMPdeam ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p emb ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p Probable nucleolar GTP-binding protein 1 ortho G G G G G G G G G G Ubi-p63E Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G WD repeat-containing protein 26 homolog Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G Gprk2 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p l(2)37Cg ortho G G G G G G G G G G Cullin 3, isoform F, FI19425p1 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p Protein BCCIP homolog ortho G G G G G G G G G G 14-3-3epsilon Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p CG9799, LD47749p ortho G G G G G G G G G His3, His3:CG31613, His3:CG33803, His3:CG33806, His3:CG33809, His3:CG33812, His3:CG33815, His3:CG33818, His3:CG33821, His3:CG33824, His3:CG33827, His3:CG33830, His3:CG33833, His3:CG33836, His3:CG33839, His3:CG33842, His3:CG33845, His3:CG33848, His3:CG33851, His3:CG33854, His3:CG33857, His3:CG33860, His3:CG33863, His3:CG33866 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho Top1 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G Cullin 4, isoform A, Cullin 4, isoform B, FI05474p, LP02965p Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G lin19 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G RpS2 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G CG9143, LD11580p Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G TER94 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G drk Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p lack ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p Pescadillo homolog ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p Nucleolar complex protein 2 homolog, Protein NOC2 homolog ortho G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p CG3335 ortho G G G G G G G G RpL3 Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p pic ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p hlc ortho G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p Cand1 ortho G G G G G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p BG:DS01068.6 ortho G G G G G G Lethal (2) 09851, isoform A, Lethal (2) 09851, isoform B, RE17371p, RE55020p sbr ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8SYL1 C0MJ66 - 15575970 - X 2 Q8SYL1 C0MJ66 two hybrid 15575970 direct interaction X 2 Q8SYL1 C0MJ66 two hybrid 15575970 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B cdc2 l(2)09851 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_21820|UniProt_41226 bait|bait prey|prey l(2)09851 CG5363 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59765 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8SYL1 P23572 L(2)09851 CDC2 0.183 15575970