PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG32369, isoform A, CG32369, isoform C EG:25E8.3 14605208 biogrid,i2d,mint,intact exp FK506-bp1 EG:25E8.3 25813344 biogrid exp G G G G G G G G G Pect-RB EG:25E8.3 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Myosin binding subunit, isoform O EG:25E8.3 14605208 biogrid,i2d,mint,intact exp G G G G G G G NetB EG:25E8.3 25294943 intact exp G G G G G Zinc transporter 63C, isoform F EG:25E8.3 14605208 biogrid,intact exp G G G G G G G G G Ribosomal RNA small subunit methyltransferase NEP1 EG:25E8.3 ortho G G G G G G G G G RpS8 EG:25E8.3 ortho G G G G G G G G G Fib EG:25E8.3 ortho G G G G G G G G G CG10206-PA, LD32943p, Nop5 EG:25E8.3 ortho G G G G G G G G G Dhx15 EG:25E8.3 ortho G G G G G G G G G Dbp45A EG:25E8.3 ortho G G G G G G G G G Cullin 3, isoform F, FI19425p1 EG:25E8.3 ortho G G G G G G G G G l(1)G0020 EG:25E8.3 ortho G G RpS5a EG:25E8.3 ortho G G G G G G G G G Su(z)12 EG:25E8.3 ortho G G G G G G G G G Sirt7 EG:25E8.3 ortho G G G G Nop56-RA EG:25E8.3 ortho G G G G G G G G G Ribosome biogenesis protein BRX1 homolog EG:25E8.3 ortho G G G G G G G G G mRpS4 EG:25E8.3 ortho G G G G G G G G G CG8064, GH01043p EG:25E8.3 ortho G G G G G G G Mannose-1-phosphate guanyltransferase beta EG:25E8.3 ortho G G G G G G G G G l(2)k09022 EG:25E8.3 ortho G G G G G G G CG2875-RB EG:25E8.3 ortho G G G G G G CG1671, LD47550p EG:25E8.3 ortho G G G G G G G G G HDAC6, isoform G EG:25E8.3 ortho G G G G G G G G G EG:25E8.3 RpL5 ortho G G G G G G G G G dbe EG:25E8.3 ortho G G G G G bys EG:25E8.3 ortho G G G G G G G G G CG30349-RA EG:25E8.3 ortho G G G G G G G G G Probable ATP-dependent RNA helicase DDX55 homolog, DEAD box protein 55 EG:25E8.3 ortho G CG11123, RH42110p EG:25E8.3 ortho G G G G G G G emb EG:25E8.3 ortho G G G G G G G G G betaTub56D EG:25E8.3 ortho G G G G G G G G G Lethal (3) 72Dn, isoform B EG:25E8.3 ortho G G G G G G G eIF-2alpha EG:25E8.3 ortho G G G G G G G G G Probable dimethyladenosine transferase EG:25E8.3 ortho G G G Sce EG:25E8.3 ortho G G G G G G Mat89Ba EG:25E8.3 ortho G hyd EG:25E8.3 ortho G G G G G G G G G Pacman, isoform B EG:25E8.3 ortho G G G G G G G G G r EG:25E8.3 ortho G Eukaryotic translation initiation factor 3 subunit K, eIF3k EG:25E8.3 ortho G G G G G G G G G APC10 EG:25E8.3 ortho G G G G G G G G G CG9799, LD47749p EG:25E8.3 ortho G G G G G G G G CG4554 EG:25E8.3 ortho G EG:25E8.3 EG:25E8.3 ortho G G G G G G G G G RpL23a EG:25E8.3 ortho G G G G G G G G G Ribosome biogenesis protein BOP1 homolog EG:25E8.3 ortho G G G G G G G Vha55 EG:25E8.3 ortho G G G G G G G G G CG3335 EG:25E8.3 ortho G G G G G G G LD17611p, U3 small nuclear riboprotein factor 55K EG:25E8.3 ortho CG7275-PA, LD28275p EG:25E8.3 ortho G G G G G G G G G CG7728-PA, LD38375p EG:25E8.3 ortho G G G G G G CG5589 EG:25E8.3 ortho G CG12325, isoform A, CG12325, isoform B, LD10780p EG:25E8.3 ortho G G G G G G CG17514, isoform A EG:25E8.3 ortho G G G G G G G G G CG2260, LD41718p EG:25E8.3 ortho G Pre-rRNA-processing protein TSR1 homolog EG:25E8.3 ortho G G G G G G G G G RRP12-like protein EG:25E8.3 ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8IP79 Q9W4Z9 - 14605208 - X 2 Q9W4Z9 Q9VSB2 - 14605208 - X 2 Q9W4Z9 - 14605208 - X 2 Q9W4Z9 Q7K3K5 two hybrid 14605208 direct interaction X 2 Q9W4Z9 M9NFF6 two hybrid 14605208 direct interaction X 2 Q9W4Z9 Q9VSB2 two hybrid 14605208 direct interaction X 2 Q9W4Z9 Q7KTB3 two hybrid 14605208 direct interaction X 2 Q8IQN4 Q9W4Z9 two hybrid 14605208 physical association X 2 Q9W4Z9 Q7K3K5 two hybrid 14605208 physical association X 2 Q9W4Z9 Q9VSB2 two hybrid 14605208 physical association X 2 Q9W4Z9 Q9VK25 two hybrid 14605208 physical association X 2 Q8IQN4 Q9W4Z9 two hybrid 14605208 physical association X 2 Q9W4Z9 Q7K3K5 two hybrid 14605208 physical association X 2 Q9W4Z9 Q9VSB2 two hybrid 14605208 physical association X 2 Q9W4Z9 Q9VK25 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EG:25E8.3 Q9VZR4 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_10347 bait prey CG32369 EG:25E8.3 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_43962|MINT_12532|UniProt_26280 prey|bait|bait bait|prey|prey Mbs EG:25E8.3 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_26279|MINT_12531 bait|bait prey|prey Pect EG:25E8.3 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_18727|UniProt_26281 null|bait prey|prey EG:25E8.3 Mbs MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_43961|DIP_20566 bait|- prey|- Pect EG:25E8.3 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_20568 - - Pect EG:25E8.3 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_32768 prey bait CG7388 EG:25E8.3 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_20567 - - ZnT63C EG:25E8.3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip) BIOGRID_42352|UniProt_56081|DIP_18152 bait|prey|- prey|bait|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9W4Z9 Q7K3K5 EG:25E8.3 ZNT63C 0.183 14605208 Q9W4Z9 Q8IQN4 EG:25E8.3 MBS 0.183 14605208 Q9W4Z9 Q9VK25 EG:25E8.3 PECT 0.183 14605208 Q9W4Z9 Q9VSB2 EG:25E8.3 Q9VSB2 0.183 14605208 Q9W4Z9 Q24568 EG:25E8.3 NETB 0.126 25294943