PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MAT1 RE28286p 15575970 intact exp MAT1 ena 15575970 biogrid,intact exp G G G G G G G G G G MAT1 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 15575970 biogrid,intact exp G G G G G G G G G G MAT1 CG33109-RA 15575970 biogrid,intact exp G G MAT1 MED15 15575970 biogrid,intact exp G G G G G G G G G G MAT1 CG12723 15575970 biogrid exp MAT1 Mesoderm-expressed 2, isoform B, SD09884p 15575970 biogrid,intact exp G G G G G G G Liprin-gamma, isoform C MAT1 15575970 biogrid,intact exp G G G G EcR MAT1 15575970 biogrid,intact exp G G G G G Vm26Ab MAT1 15575970 biogrid,intact exp G Cyclin-dependent kinase 7, IP01401p MAT1 22036573 biogrid exp, ortho G G G G G G G G G G Cyclin H, Cyclin H homolog MAT1 22036573 biogrid exp, ortho G G G G G G G G G G MAT1 Tfb5-RB ortho MAT1 Spt5 ortho G G G G G G G G G G MAT1 Marionette ortho G G G G G G G G G G Hsp60 MAT1 ortho G G G G G G G G G G MAT1 Mcm7 ortho G betaTub56D MAT1 ortho G G G G G G G G G G MAT1 Ubc12 ortho G G G G G G G G G G pug MAT1 ortho G G G G G G G G G G Cyclin-dependent kinase 9, GH21935p, Positive transcription elongation factor b small subunit MAT1 ortho G G G G G G G G G G MAT1 Rpb4 ortho TfIIE-beta MAT1 ortho G G G G G G G G G G MAT1 CG5041-PA, FI01003p ortho G G G G MAT1 MAT1 ortho G G G G G G G G G G hay MAT1 ortho G G G G G G G G G MAT1 hlc ortho G G G G G G G G G MAT1 Tfb1 ortho G G G G G G G G G G cdc2c MAT1 ortho G G G RpII215 MAT1 ortho G G G G G G G G G G MAT1 Early girl, isoform A, Early girl, isoform B, LD41235p ortho G G G G G G G G G G MAT1 CG9281, isoform B, CG9281, isoform C, CG9281, isoform D, LD02975p ortho G G G G G G G G G MAT1 Xeroderma pigmentosum D ortholog ortho G G G eff MAT1 ortho G G G G G G G G G G 14-3-3epsilon MAT1 ortho G G G G G G G G G G MAT1 CG11399-RB ortho G G G G G G G RpA-70 MAT1 ortho G G G G G G G G G G Roc2-RA MAT1 ortho G G G G G G G G G G MAT1 CG9273 protein, CG9273-PA, GM04951p, Replication protein A2, isoform A, Replication protein A2, isoform B ortho G G G MAT1 CSN6 ortho G G G G G G G G G G Mannose-1-phosphate guanyltransferase beta MAT1 ortho G G G G G G G G G G MAT1 GH08526p, Suppressor of Stem-Loop mutation ortholog, isoform A, Suppressor of Stem-Loop mutation ortholog, isoform B ortho G G G G G G G G G G Vha55 MAT1 ortho G G G G G G G G G G RPB3 MAT1 ortho G G G G G G G G G G Trim9, isoform B MAT1 ortho G G G DMAP1, LD35228p MAT1 ortho G G G G G G G G G G Hsc70Cb, isoform G, Hsc70Cb, isoform H MAT1 ortho G G G G G G G G G G MTA1-like MAT1 ortho G G G G G G G G G CG34231 MAT1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P13238 Q7KPG8 - 15575970 - X 2 Q9VFL9 Q7KPG8 - 15575970 - X 2 Q7KPG8 Q9Y149 - 15575970 - X 2 Q7Z2C5 Q7KPG8 - 15575970 - X 2 Q7KPG8 Q8T4F7 two hybrid 15575970 direct interaction X 2 P13238 Q7KPG8 two hybrid 15575970 direct interaction X 2 Q9VFL9 Q7KPG8 two hybrid 15575970 direct interaction X 2 A4UZ51 Q7KPG8 two hybrid 15575970 direct interaction X 2 Q7KPG8 Q9VNP3 two hybrid 15575970 direct interaction X 2 Q7KPG8 A8JNJ2 two hybrid 15575970 direct interaction X 2 Q7KPG8 Q9Y149 two hybrid 15575970 direct interaction X 2 Q7Z2C5 Q7KPG8 two hybrid 15575970 direct interaction X 2 Q24216 Q7KPG8 affinity chromatography technology 22036573 physical association X 2 Q7KPG8 two hybrid 15575970 direct interaction X 2 O76513 Q7KPG8 affinity chromatography technology 22036573 physical association X 2 Q9I7T8 Q7KPG8 two hybrid 15575970 physical association X 2 Q7KPG8 Q8T4F7 two hybrid 15575970 physical association X 2 P13238 Q7KPG8 two hybrid 15575970 physical association X 2 Q9W263 Q7KPG8 two hybrid 15575970 physical association X 2 Q8IG95 Q7KPG8 two hybrid 15575970 physical association X 2 Q9VFL9 Q7KPG8 two hybrid 15575970 physical association X 2 E1JGY2 Q7KPG8 two hybrid 15575970 physical association X 2 Q7KPG8 Q9Y149 two hybrid 15575970 physical association X 2 Q9VYF9 Q7KPG8 two hybrid 15575970 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Mat1 Mes2 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40625 bait prey Mat1 CG11486 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59492 bait prey Mat1 MED15 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_40909|BIOGRID_59506 bait|bait prey|prey Vm26Ab Mat1 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_40320|BIOGRID_58945 prey|prey bait|bait EcR Mat1 MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_40977|BIOGRID_59572 prey|prey bait|bait Mat1 ena MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_59466|UniProt_40867 bait|bait prey|prey Mat1 Mes2 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59243 bait prey Mat1 Liprin-gamma MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40997 bait prey Mat1 CG12723 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59265 bait prey Mat1 CG33109-RA MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_59615|UniProt_41026 bait|bait prey|prey Mat1 CG11486-RB MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40895 bait prey Cdk7 Mat1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66304 bait prey Mat1 CG12723 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40649 bait prey CycH Mat1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64965 bait prey Mat1 Liprin-gamma MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59588 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9I7T8 Q7KPG8 CG11486-RB MAT1 0.183 15575970 Q8IG95 Q7KPG8 MES2 MAT1 0.183 15575970 Q8T4F7 Q7KPG8 ENA MAT1 0.183 15575970 Q9Y149 Q7KPG8 MED15 MAT1 0.183 15575970 Q7KPG8 P13238 MAT1 VM26AB 0.183 15575970 Q7KPG8 P34021 MAT1 ECR 0.183 15575970 Q9VFL9 Q7KPG8 CG33109-RA MAT1 0.183 15575970 Q9VYF9 Q7KPG8 Q9VYF9 MAT1 0.183 15575970 Q9W263 Q7KPG8 LIPRIN-GAMMA MAT1 0.183 15575970