PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bub1 Bub3-RA 14605208 biogrid,intact exp G G Bub3-RA PPP5 25294943 intact exp G G G G G G G G G G Bub3-RA RpL18 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G BubR1 Bub3-RA i2d exp Iap2 Bub3-RA 23749869 biogrid exp G G G G G G G G G G Rel Bub3-RA 23749869 biogrid exp G G G G G G G G G G Tab2-RA Bub3-RA 23749869 biogrid exp G G G G G G G G Bub3-RA PGRP-LE 23749869 biogrid exp G G G G G G G G G G Bub3-RA Bub1 homologue, isoform A, Bub1 homologue, isoform B, Bub1 homologue, isoform C, LD22858p 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G Bub3-RA ird5 23749869 biogrid exp G G G G G G G G Bub3-RA APC4-RA ortho G G G Bub3-RA CG9273 protein, CG9273-PA, GM04951p, Replication protein A2, isoform A, Replication protein A2, isoform B ortho G G G Bub3-RA Usp7 ortho G G G G G G G G G G Bub3-RA defl-RA ortho G G G G G G Bx42 Bub3-RA ortho G G G G G G G G G G Bub3-RA Cell division cycle 27 ortholog, isoform A, Cell division cycle 27 ortholog, isoform B, LD12661p ortho G G G G G G G G G Bub3-RA Tweek, isoform J ortho G G G G G G G G G G GM12270p, T-complex chaperonin 5, isoform A Bub3-RA ortho G G G G G G G G G G Rpd3 Bub3-RA ortho G G G G G G G G G Bub3-RA CG9198-PA, isoform A ortho G G G Bub3-RA CG32672-PA, LD05816p ortho G G G G G G G G G G Bub3-RA T-complex protein 1 subunit delta ortho G G G G G G G G G G Cullin 3, isoform F, FI19425p1 Bub3-RA ortho G G G G G G G G G G 14-3-3epsilon Bub3-RA ortho G G G G G G G G G G Bub3-RA Methyltransferase-like protein 13 ortho G G G G G G G G G Bub3-RA CG7033, SD02216p ortho G G G G G G G G G G Medea Bub3-RA ortho G G G G G G G G G Bub3-RA Imaginal discs arrested ortho G G Parp Bub3-RA ortho Bub3-RA GH01161p, TNF-receptor-associated factor 6 ortho G G G G G G G G G His3, His3:CG31613, His3:CG33803, His3:CG33806, His3:CG33809, His3:CG33812, His3:CG33815, His3:CG33818, His3:CG33821, His3:CG33824, His3:CG33827, His3:CG33830, His3:CG33833, His3:CG33836, His3:CG33839, His3:CG33842, His3:CG33845, His3:CG33848, His3:CG33851, His3:CG33854, His3:CG33857, His3:CG33860, His3:CG33863, His3:CG33866 Bub3-RA ortho Bub3-RA Bub3-RA ortho G G G G G G G G G G Bub3-RA Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p ortho G G G G G G G Sep1 Bub3-RA ortho G G G G G G G G G G emb Bub3-RA ortho G G G G G G G G G G Bub3-RA Mad2, RE72064p ortho G G fzy-RA Bub3-RA ortho G G GH24511p, Ubiquitin activating enzyme 1, isoform A Bub3-RA ortho G G G G G G G G G G RpA-70 Bub3-RA ortho G G G G G G G G G G sec6 Bub3-RA ortho G G G G G G G G Bub3-RA cdc16 ortho G G G G G G G G Bub3-RA CG8184, isoform H ortho G G G G G G G G G G Bub3-RA RpL37A ortho G G G G G G G G G G Bub3-RA Rae1 ortho G G G G G G G G G G hyd Bub3-RA ortho G G G G G G G G G G Bub3-RA CG9617-RA ortho G G G G G G G G G G Top1 Bub3-RA ortho G G G G G G G G G Bub3-RA LD47396p, Tcp-1eta ortho G G G G G G G G G G Bub3-RA CG4291-RA ortho Bub3-RA CSN5 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VAJ2 Q9VMS5 - 14605208 - X 2 Q9VAJ2 Q9VJI6 - 14605208 - X 2 Q9VAJ2 A1Z6I7 - 14605208 - X 2 Q9VAJ2 affinity chromatography technology 23749869 physical association X 2 Q9VAJ2 Q6NQZ7 affinity chromatography technology 23749869 physical association X 2 Q9VAJ2 Q9VMS5 two hybrid 14605208 direct interaction X 2 Q9VAJ2 A1Z6I7 two hybrid 14605208 direct interaction X 2 Q9VAJ2 Q9VXN9 affinity chromatography technology 23749869 physical association X 2 Q9VAJ2 Q94527-2 affinity chromatography technology 23749869 physical association X 2 Q9VAJ2 Q24307 affinity chromatography technology 23749869 physical association X 2 Q9VAJ2 Q9VJI6 two hybrid 14605208 direct interaction X 2 Q9VAJ2 Q9VMS5 two hybrid 14605208 physical association X 2 Q9VAJ2 Q9VJI6 two hybrid 14605208 physical association X 2 Q9VAJ2 A1Z6I7 two hybrid 14605208 physical association X 2 Q9VAJ2 Q9VMS5 two hybrid 14605208 physical association X 2 Q9VAJ2 Q9VJI6 two hybrid 14605208 physical association X 2 Q9VAJ2 A1Z6I7 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Bub3 PGRP-LE MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75761 prey bait Bub3 CG17912 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_18408 - - Bub3 BubR1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_33786|UniProt_52830 bait|bait prey|prey Bub3 Q9XZ59 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_17241 bait prey Bub3 CG17912 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint) UniProt_56338|BIOGRID_32385|MINT_10572 bait|prey|bait prey|bait|prey Bub3 Bub1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0465(dip)|(biogrid)|MI:0471(mint) UniProt_47277|DIP_13961|BIOGRID_31421|MINT_28907 bait|-|prey|bait prey|-|bait|prey Tab2 Bub3 MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_76246 bait prey Bub3 ird5 MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75969 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VH81 Q9VAJ2 Q9VH81 BUB3 0.126 25294943 Q9VJI6 Q9VAJ2 Q9VJI6 BUB3 0.183 14605208 Q9VMS5 Q9VAJ2 BUB1 BUB3 0.183 14605208 Q9VAJ2 A1Z6I7 BUB3 BUBR1 0.183 14605208