PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CSN6 Hsp60B 14605208 biogrid,i2d,mint,intact exp G Abd-B CSN6 14605208 biogrid,i2d,mint,intact exp G G CSN6 CSN6 22575649 intact exp, ortho G G G G G G G G G G CSN4 CSN6 14605208,22036573 biogrid,i2d,mint,intact exp, ortho G G G G G G G G G G CSN6 CSN5 14605208 biogrid,i2d,mint,intact exp, ortho G G G G G G G G G G CSN7 CSN6 22036573 biogrid exp, ortho G G G G G G G G G G alien CSN6 22036573 biogrid exp, ortho G G G G G G G G G G CG10465, RE57120p CSN6 ortho G G G G G G G G G G Cullin 5, FI20194p1 CSN6 ortho G G G G G G G G G G DNApol-delta CSN6 ortho G G G G No child left behind CSN6 ortho G G G G Elongin C, isoform A, Elongin C, isoform B, RE05591p, RH71704p CSN6 ortho G G G G G G G G G G CSN6 Rae1 ortho G G G G G G G G G G Cks30A CSN6 ortho G G Rpn11 CSN6 ortho G G G G G G G G G G RpL11 CSN6 ortho G G G G G G G G G G CSN6 Methyltransferase 2, isoform C, Methyltransferase 2, isoform D ortho CycA CSN6 ortho G G Cullin 3, isoform F, FI19425p1 CSN6 ortho G G G G G G G G G G cdc2c CSN6 ortho G G G MAPk-Ak2 CSN6 ortho G G G G G G G G G G CSN6 rogdi ortho G G G G G G G G G Atg18 CSN6 ortho G G G G G G G G G G CSN6 DCN1-like protein ortho G G G G G G G G G G SkpA CSN6 ortho G G G G G G G G G G Skp2, isoform A, Skp2, isoform E CSN6 ortho G G G G CSN6 Usp7 ortho G G G G G G G G G G CSN6 Nedd8 ortho G G G G G G G G G G CG10077, isoform D, CG10077-PA, isoform A, GH10652p CSN6 ortho G G G G G G G G G G CSN6 BTB (POZ) domain containing 9 ortholog, isoform A, BTB (POZ) domain containing 9 ortholog, isoform B, LD01947p ortho G G G G G G G G G G RpS4 CSN6 ortho G G G G G G G G G G Glycoprotein 93, LD23641p CSN6 ortho G G G G G G G G G G CSN6 SmG ortho G G G G G G G G G G CSN6 CG16733-RA ortho CSN6 Tumor suppressor protein 101, Tumor susceptibility gene 101 ortholog ortho G G G G G G G G G G CSN6 GH10889p, Protein interacting with APP tail-1, isoform A, Protein interacting with APP tail-1, isoform C ortho G G G G G G G G G G Bx42 CSN6 ortho G G G G G G G G G G CSN6 Ppa ortho G G G G G G G G CSN6 bel ortho G G G G G G G G G G CSN6 RpL24 ortho G G G G G G G G G G CSN3 CSN6 ortho G G G G G G G G G G Hsc70-5 CSN6 ortho G G G G G G G G G G Ubi-p63E CSN6 ortho G G G G G G G G G G RpS2 CSN6 ortho G G G G G G G G G G Rox8-RD CSN6 ortho G G G G G G G G G G CSN6 Ribosomal protein S30, isoform A, Ribosomal protein S30, isoform B, Ribosomal protein S30, isoform C ortho G G G G G G G G G G CSN6 Tgt ortho G G G RE08669p, Ribosomal protein L6, isoform B CSN6 ortho G G G G G G G G G G AT18160p, CG9945, isoform A, CG9945, isoform B CSN6 ortho G G G G G SdhA CSN6 ortho G G G G G G G G G G RpS20 CSN6 ortho G G G G G G G G G G CSN6 Loquacious, isoform B, R3D1-L, RE14437p ortho G G G G G G G G G G FeCh CSN6 ortho G G G G G G G G G G CSN6 CG3313, isoform A, CG3313, isoform B, LD21841p ortho G G G G RpS11 CSN6 ortho G G G G G G G G G G Syx5 CSN6 ortho G G G G G G G G G G Hsc70-3 CSN6 ortho G G G G G G G G G G CSN6 CG9467, LD44003p ortho G G G G G G G G G G betaTub56D CSN6 ortho G G G G G G G G G G e(r) CSN6 ortho G G G G G G G G G G Set1/Ash2 histone methyltransferase complex subunit ASH2 CSN6 ortho G G G G G G G G G G CSN6 CG5313-PA, Replication factor C subunit 3, SD11293p ortho G G CSN6 SMC3 ortho G G CSN6 Toys are us ortho G G G G G G Ef1alpha100E CSN6 ortho G G G G G G CSN6 AnxB11 ortho G G G G G G G G G G EG:80H7.4 protein, LP12150p, Rab27, isoform B CSN6 ortho G G G CSN6 CSN1b ortho G G G G G G G G G G CSN6 CG9273 protein, CG9273-PA, GM04951p, Replication protein A2, isoform A, Replication protein A2, isoform B ortho G G G RpL8 CSN6 ortho G G G G G G G G G G Cpsf160 CSN6 ortho G G G G G G G CSN6 RpL18 ortho G G G G G G G G G G CG6459 protein, CG6459-PA, LD29590p, P32 CSN6 ortho G G G G G G G G G G RpL4 CSN6 ortho G G G G G G G G G G CSN6 RpL38 ortho G G G G G G G G G G DNApol-alpha50 CSN6 ortho G CoVa CSN6 ortho G G G G G G G G G G IP16020p, Phosphatase PTEN, Pten, isoform B, Pten, isoform D, Pten, isoform G, Pten, isoform H CSN6 ortho G G G G G G G G G RpL23 CSN6 ortho G G G G G G G G G G Fem-1 CSN6 ortho G G G G G G G G G G Cullin 2, isoform A, Cullin 2, isoform B, LD36177p CSN6 ortho G G G G G G G G G G CSN6 CG11586-RA ortho G G G G G G G G CSN6 RRP12-like protein ortho G G G G G G G G G G CSN6 CG14614-RA ortho G G G G G G G G G CSN6 KLHL18, isoform A, KLHL18, isoform C, LD42169p ortho G G G G G G G G G G CSN6 Sfmbt ortho G G G G G G G G G CSN6 FBXO11 ortho G G G G G G G G G Rpn6 CSN6 ortho G G G G G G G G G G CSN6 BcDNA.GH08312 ortho G G G G G G G G G G CSN6 CG12081, isoform A, CG12081, isoform B, LD20420p ortho G G G G G G G G G G EF2 CSN6 ortho G G G G G G G G G G Uch CSN6 ortho G G G G G G G G G G CSN8 CSN6 ortho G G G G G G G G G G lin19 CSN6 ortho G G G G G G G G G G CSN6 Kelch-like protein diablo ortho G G G G G G G G G MAT1 CSN6 ortho G G G G G G G G G G CSN6 GH06740p, Leucine-rich repeat 47, isoform A, Leucine-rich repeat 47, isoform B ortho G G RpL15 CSN6 ortho G G G G G G G G G G Hsc70-1 CSN6 ortho G G CSN6 Jetlag, isoform A ortho G G 14-3-3epsilon CSN6 ortho G G G G G G G G G G CSN6 SmD1 ortho G G G G G G G G G G Trx-2 CSN6 ortho G G G G G G G G G G Cullin 4, isoform A, Cullin 4, isoform B, FI05474p, LP02965p CSN6 ortho G G G G G G G G G G CSN6 Ubc12 ortho G G G G G G G G G G Ribonuclease P protein subunit p20, RNaseP protein p20 CSN6 ortho CSN6 pic ortho G G G G G G G G G G Rep CSN6 ortho G G G G G G G G G eIF3-S6 CSN6 ortho G G G G G G G G G G CSN6 CG7264, isoform A, CG7264, isoform B, RE41410p ortho G CSN6 Roc1a ortho G G G G G G G G G CSN6 CG1812, LD33804p ortho G G G G G G G CSN6 mahj ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VCY3 Q9VPS5 - 14605208 - X 2 E1JH01 Q9VCY3 - 14605208 - X 2 Q9XZ58 Q9VCY3 - 14605208 - X 2 A4V304 Q9VCY3 - 14605208 - X 2 Q9VCY3 Q9VPS5 two hybrid 14605208 direct interaction X 2 E1JH01 Q9VCY3 two hybrid 14605208 direct interaction X 2 E1JH01 Q9VCY3 affinity chromatography technology 22036573 physical association X 2 Q9VCY3 two hybrid 14605208 direct interaction X 2 M9PFB5 Q9VCY3 affinity chromatography technology 22036573 physical association X 2 Q9XZ58 Q9VCY3 two hybrid 14605208 direct interaction X 2 Q9V4S8 Q9VCY3 affinity chromatography technology 22036573 physical association X 2 Q9VCY3 Q9VPS5 two hybrid 14605208 physical association X 2 E1JH01 Q9VCY3 anti tag coimmunoprecipitation 25119050 physical association X 2 E1JH01 Q9VCY3 two hybrid 14605208 physical association X 2 Q9XZ58 Q9VCY3 anti tag coimmunoprecipitation 25119050 physical association X 2 Q9XZ58 Q9VCY3 two hybrid 14605208 physical association X 2 Q9V4S8 Q9VCY3 anti tag coimmunoprecipitation 25119050 physical association X 2 P09087 Q9VCY3 two hybrid 14605208 physical association X 2 Q9VCY3 Q9VPS5 two hybrid 14605208 physical association X 2 E1JH01 Q9VCY3 two hybrid 14605208 physical association X 2 Q9VCY3 Q9VCY3 x-ray crystallography 22575649 direct interaction Y 1 Q9VCY3 Q9VCY3 x ray scattering 22575649 direct interaction Y 1 Q9XZ58 Q9VCY3 two hybrid 14605208 physical association X 2 P09087 Q9VCY3 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CSN6 CSN5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip)|MI:0471(mint) BIOGRID_31765|UniProt_48741|DIP_15444|MINT_7787 prey|prey|-|prey bait|bait|-|bait Trc8 CSN6 MI:0018(two hybrid) 15735686 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_75277 bait prey CSN7 CSN6 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_72764 bait prey alien CSN6 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_72015 bait prey CSN6 Hsp60B MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0465(dip)|(biogrid)|MI:0471(mint) UniProt_25698|DIP_19984|BIOGRID_43557|MINT_11972 prey|-|prey|prey bait|-|bait|bait CSN4 CSN6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|MI:0465(dip)|MI:0471(mint) BIOGRID_47194|UniProt_63167|BIOGRID_71136|DIP_25259|MINT_16919 prey|bait|bait|-|bait bait|prey|prey|-|prey Abd-B CSN6 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|MI:0465(dip) MINT_18137|BIOGRID_37026|UniProt_63905|DIP_9846 null|bait|null|- prey|prey|prey|- CSN6 CSN6 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 22575649 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact) UniProt_46709|UniProt_46710 neutral component|neutral component neutral component|neutral component

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VCY3 Q9VCY3 CSN6 CSN6 0.554 22575649 Q9VCY3 Q94899 CSN6 ALIEN 0.126 22036573 Q9VCY3 Q9V345 CSN6 CSN4 0.416 22036573,14605208 Q9VCY3 Q9V4S8 CSN6 CSN7 0.126 22036573 Q9VCY3 P09087 CSN6 ABD-B 0.354 14605208 Q9VPS5 Q9VCY3 HSP60B CSN6 0.354 14605208 Q9XZ58 Q9VCY3 CSN5 CSN6 0.354 14605208