PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ten-m LD24662p, Transport and golgi organization 4 25294943 intact exp G G G G G G G CG6015, LD21931p LD24662p, Transport and golgi organization 4 22036573 biogrid exp G G G G G G G G G CG15067, isoform A, CG15067, isoform B LD24662p, Transport and golgi organization 4 14605208 biogrid,intact exp G G G G G G AT21926p, Steamer duck, isoform C LD24662p, Transport and golgi organization 4 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G CG14641, LD46870p LD24662p, Transport and golgi organization 4 22036573 biogrid exp G G G G G G G G G Spinophilin, isoform J LD24662p, Transport and golgi organization 4 25294943 intact exp G G G G G G LD24662p, Transport and golgi organization 4 Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p 22036573 biogrid exp, ortho G G G G G G G BCAS2 ortholog, LD24242p LD24662p, Transport and golgi organization 4 22036573 biogrid exp, ortho G G G G Bx42 LD24662p, Transport and golgi organization 4 22036573 biogrid exp, ortho G G G G G G G G G CG9667, isoform A, RE31520p LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G CG4572-RC LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G CG8435, LD32459p LD24662p, Transport and golgi organization 4 ortho G G G G G G G G CG11964, LD41978p LD24662p, Transport and golgi organization 4 ortho G G G CG16941, GH03554p LD24662p, Transport and golgi organization 4 ortho G G Cbp20 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G l(1)G0022 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G SD09427p, U4-U6 small nuclear riboprotein factor 60K LD24662p, Transport and golgi organization 4 ortho G G G G G G G G CG5608-RA LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G ATPsyn-beta LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G prp8 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Mitochondrial ribosomal protein L40, RE65766p LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Hsc70Cb, isoform G, Hsc70Cb, isoform H LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G LD24662p, Transport and golgi organization 4 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G c12.1 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Dhx15 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G lethal(1)10Bb LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G abs LD24662p, Transport and golgi organization 4 ortho G G G G G G G G RpL9 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G U6 snRNA phosphodiesterase LD24662p, Transport and golgi organization 4 ortho G CG6197-RA LD24662p, Transport and golgi organization 4 ortho G G G G G G G G Adaptor protein complex 2, mu subunit, isoform A, Adaptor protein complex 2, mu subunit, isoform B, Adaptor protein complex 2, mu subunit, isoform C, Clathrin-associated adaptor complex AP-2 medium chain, Clathrin-associated protein, SD05403p LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G eIF3-S9 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Hsc70-3 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Precursor RNA processing 3, isoform A LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Vha55 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G LD24662p, Transport and golgi organization 4 Fib ortho G G G G G G G G G SmD2 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G noi LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Rpb4 LD24662p, Transport and golgi organization 4 ortho CG9302-RA LD24662p, Transport and golgi organization 4 ortho G G G G G G G 14-3-3epsilon LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G r LD24662p, Transport and golgi organization 4 ortho G emb LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Pen LD24662p, Transport and golgi organization 4 ortho G U2af50 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Uch LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Eukaryotic initiation factor 4A-III, eIF-4A-III, eIF4A-III LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G l(3)72Ab LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Pkc98E LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G Hsp60 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G CG11876, isoform A, CG11876, isoform D, GH08474p LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G CG4849, LD28793p LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G U2A LD24662p, Transport and golgi organization 4 ortho G Su(z)12 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G CG8258, LD24495p LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G CG2807, isoform A, CG2807, isoform B LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G pAbp LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G GM12270p, T-complex chaperonin 5, isoform A LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G LD24662p, Transport and golgi organization 4 CG13900-RA ortho G G G G G G G G G Cullin 3, isoform F, FI19425p1 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G BcDNA.LD02793, Prp19 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G CG1375 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G LD24662p, Transport and golgi organization 4 Upf1 ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A1ZB61 Q9VYQ9 - 14605208 - X 2 Q9VYQ9 Q8INQ9 - 14605208 - X 2 Q9W0R0 Q9VYQ9 affinity chromatography technology 22036573 physical association X 2 Q9VYQ9 Q9XYA7 two hybrid 14605208 direct interaction X 2 Q9VYQ9 Q9VAY6 affinity chromatography technology 22036573 physical association X 2 Q9VYQ9 P39736 affinity chromatography technology 22036573 physical association X 2 A1ZB61 Q9VYQ9 two hybrid 14605208 direct interaction X 2 Q9VYQ9 Q95RB1 affinity chromatography technology 22036573 physical association X 2 Q9VD52 Q9VYQ9 affinity chromatography technology 22036573 physical association X 2 A1ZB61 Q9VYQ9 two hybrid 14605208 physical association X 2 Q9VYQ9 Q8INQ9 two hybrid 14605208 physical association X 2 A1ZB61 Q9VYQ9 two hybrid 14605208 physical association X 2 Q9VYQ9 Q8INR0 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CG4980 Tango4 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_72575 prey bait CG6905 Tango4 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70639 prey bait Tango4 CG15067 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_40691|UniProt_59605 prey|prey bait|bait stck Tango4 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_10669|UniProt_56439 bait|bait prey|prey Tango4 stck MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_42615 bait prey CG14641 Tango4 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74102 prey bait CG6015 Tango4 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71723 prey bait Q9V8F8 Tango4 MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_7974 bait prey Bx42 Tango4 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74429 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VYQ9 O61307 TANGO4 TEN-M 0.126 25294943 Q9VYQ9 M9NFI9 TANGO4 M9NFI9 0.236 25294943 Q9VYQ9 A1ZB61 TANGO4 A1ZB61 0.183 14605208 Q9VYQ9 Q8INR0 TANGO4 STCK 0.183 14605208