PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SD10969p hiw 16603075 intact exp ptc hiw 15710747 biogrid,i2d,intact exp hiw CG5059-PA, isoform A, RE48077p 25294943 intact exp G G G G G Spinophilin, isoform J hiw 25294943 intact exp G G G G hiw sec5 15710747 biogrid,i2d,intact exp G G G G G hiw Vps26 ortho G G G G G hiw Rep ortho G G G G SAK hiw ortho G hiw Non-specific serine/threonine protein kinase ortho G G G G G hiw MED4 ortho G hiw CG8665-RA ortho hiw Sirt7 ortho G G G hiw Gigas, isoform A ortho G G G G G hiw Sesn ortho G G G G hiw Rae1 ortho G G G G G 14-3-3zeta hiw ortho G G G hiw Fsn ortho G G G G G Cullin 4, isoform A, Cullin 4, isoform B, FI05474p, LP02965p hiw ortho G G G G G hiw HdacX-RA ortho G G G Ubi-p63E hiw ortho G G G G G WD repeat-containing protein 48 homolog hiw ortho G G G G hiw As ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NB71 P18502 two hybrid 15710747 direct interaction X 2 Q9VQQ9 Q9NB71 two hybrid 15710747 direct interaction X 2 Q8IGE8 Q9NB71 two hybrid fragment pooling approach 15710747 physical association X 2 Q9NB71 Q95R37 two hybrid 16603075 physical association X 2 Q9VQQ9 Q9NB71 two hybrid fragment pooling approach 15710747 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ptc hiw MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_41948 bait prey hiw sec5 MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_41549 prey bait CG12393 hiw MI:0018(two hybrid) 16603075 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44444 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NB71 Q8IGE8 HIW PTC 0.126 15710747 Q9NB71 Q95R37 HIW Q95R37 0.183 16603075 Q9NB71 Q8IPU8 HIW Q8IPU8 0.126 25294943 Q9VQQ9 Q9NB71 SEC5 HIW 0.286 15710747 Q9NB71 P18502 HIW PTC 0.183 15710747 Q9NB71 M9NFI9 HIW M9NFI9 0.126 25294943