PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ubiquitin thioesterase otubain-like Ubc7 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G Ubiquitin thioesterase otubain-like CG11164, isoform A, CG11164, isoform B 14605208 biogrid,i2d,mint,intact exp G Ubi-p63E Ubiquitin thioesterase otubain-like ortho G G G G G G G G G G eff Ubiquitin thioesterase otubain-like ortho G G G G G G G G G G 14-3-3epsilon Ubiquitin thioesterase otubain-like ortho G G G G G G G G G G Medea Ubiquitin thioesterase otubain-like ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VL00 Q9VYA4 - 14605208 - X 2 Q9VXE8 Q9VL00 - 14605208 - X 2 Q9VL00 Q9VYA4 two hybrid 14605208 direct interaction X 2 Q9VXE8 Q9VL00 two hybrid 14605208 direct interaction X 2 Q9VL00 Q9VYA4 two hybrid 14605208 physical association X 2 Q9VXE8 Q9VL00 two hybrid 14605208 physical association X 2 Q9VL00 Q9VYA4 two hybrid 14605208 physical association X 2 Q9VXE8 Q9VL00 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CG4968 CG11164 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|MI:0471(mint)|(biogrid) UniProt_54504|DIP_8423|MINT_23698|BIOGRID_36031 bait|-|bait|prey prey|-|prey|bait CG4968 crl MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|(biogrid) MINT_15179|UniProt_50608|BIOGRID_33265 bait|bait|prey prey|prey|bait