PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Defective in cullin neddylation protein CG6230-RA 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G dec-1 Defective in cullin neddylation protein i2d exp dec-1 Defective in cullin neddylation protein 14605208 biogrid,i2d,mint,intact exp G Defective in cullin neddylation protein RpL38 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G Defective in cullin neddylation protein CG4972-RA 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G SkpA Defective in cullin neddylation protein 19079254 intact exp G G G G G G G G G G shi Defective in cullin neddylation protein 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Cullin 4, isoform A, Cullin 4, isoform B, FI05474p, LP02965p Defective in cullin neddylation protein 14605208 biogrid,intact exp, ortho G G G G G G G G G G Defective in cullin neddylation protein Cand1 ortho G G G G G G G G G G Defective in cullin neddylation protein Ubc12 ortho G G G G G G G G G G Defective in cullin neddylation protein Cullin 2, isoform A, Cullin 2, isoform B, LD36177p ortho G G G G G G G G G G Defective in cullin neddylation protein Roc1a ortho G G G G G G G G G Defective in cullin neddylation protein Top3alpha ortho G G G G G lin19 Defective in cullin neddylation protein ortho G G G G G G G G G G Cullin 3, isoform F, FI19425p1 Defective in cullin neddylation protein ortho G G G G G G G G G G Defective in cullin neddylation protein Cullin 5, FI20194p1 ortho G G G G G G G G G G lethal(1)10Bb Defective in cullin neddylation protein ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8T8S1 Q9VKJ6 - 14605208 - X 2 Q9W5N2 Q8T8S1 - 14605208 - X 2 P18170 Q8T8S1 - 14605208 - X 2 Q8T8S1 Q9VKZ7 - 14605208 - X 2 Q5BI50 Q8T8S1 - 14605208 - X 2 Q8T8S1 A4V4J0 two hybrid 14605208 direct interaction X 2 Q8T8S1 Q9VKJ6 two hybrid 14605208 direct interaction X 2 Q9W5N2 Q8T8S1 two hybrid 14605208 direct interaction X 2 Q8T8S1 M9NG31 two hybrid 14605208 direct interaction X 2 Q8T8S1 Q9VKZ7 two hybrid 14605208 direct interaction X 2 Q5BI50 Q8T8S1 two hybrid 14605208 direct interaction X 2 P18171 Q8T8S1 two hybrid 14605208 physical association X 2 Q8T8S1 Q9VKJ6 two hybrid 14605208 physical association X 2 Q9W5N2 Q8T8S1 two hybrid 14605208 physical association X 2 A4V4I8 Q8T8S1 two hybrid 14605208 physical association X 2 Q8T8S1 Q9VKZ7 two hybrid 14605208 physical association X 2 Q5BI50 Q8T8S1 two hybrid 14605208 physical association X 2 P18171 Q8T8S1 two hybrid 14605208 physical association X 2 Q8T8S1 A4V4J0 two hybrid 14605208 physical association X 2 Q8T8S1 Q9VKJ6 two hybrid 14605208 physical association X 2 Q9W5N2 Q8T8S1 two hybrid 14605208 physical association X 2 Q8T8S1 Q9VKZ7 two hybrid 14605208 physical association X 2 Q8T8S1 O77430 two hybrid array 19079254 physical association X 2 Q5BI50 Q8T8S1 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B shi CG13322 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact) DIP_12832|MINT_18261|UniProt_52158 -|null|null -|bait|bait ANXA1 CG13322 MI:0018(two hybrid) 14605208 taxid:9606(Homo sapiens) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_12835 - - skpA CG13322 MI:0397(two hybrid array) 19079254 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_43837 bait prey Cul-4 CG13322 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_52163 prey bait dec-1 CG13322 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact) DIP_12833|MINT_27825|UniProt_52159 -|prey|prey -|bait|bait CG13322 RpL38 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_52160|MINT_27826 bait|bait prey|prey CG13322 CG4972 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_27827|UniProt_52161 bait|bait prey|prey CG13322 CG6230-RA MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip)|(intact) MINT_27828|DIP_12836|UniProt_52162 bait|-|bait prey|-|prey CG13322 Q9V365 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_27829 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8T8S1 Q5BI50 Q8T8S1 CUL4 0.183 14605208 Q8T8S1 O77430 Q8T8S1 SKPA 0.236 19079254 Q8T8S1 P18171 Q8T8S1 DEC-1 0.21 14605208 Q8T8S1 P27619 Q8T8S1 SHI 0.21 14605208 Q9VKJ6 Q8T8S1 CG6230-RA Q8T8S1 0.183 14605208 Q9VKZ7 Q8T8S1 CG4972-RA Q8T8S1 0.183 14605208 Q9W5N2 Q8T8S1 RPL38 Q8T8S1 0.183 14605208