PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rpn13 GH11341p, Hypothetical 55kDa protein, Regulatory particle non-ATPase 5 22036573 biogrid exp G G G G G G G G G G Rpn13 26S proteasome regulatory complex subunit p50, GH12068p, Regulatory particle triple-A ATPase 5 22036573 biogrid exp G G G G G G G G G G Rpn13 26S proteasome regulatory complex subunit p30, CG4157-PA, RE36854p 22036573 biogrid exp G G G G G G G G G G Rpn13 Rpn2 14605208,22036573 biogrid,i2d,intact exp G G G G G G G G G G Rpn13 Rpn11 22036573 biogrid exp G G G G G G G G G G Rpn13 CG15262-RA 14605208 biogrid,i2d,intact exp G Rpn13 LD40758p, Ras association family member 15710747 biogrid,i2d exp G G G G G G G G G G Prosalpha3 Rpn13 22036573 biogrid exp G G G G G G G G G G Rpn13 VhaM9.7-b i2d exp Rpn13 Rpn13R 14605208 biogrid,i2d,intact exp G Rpn13 Prosalpha1 22036573 biogrid exp RpS27A Rpn13 24292889 biogrid exp G G G G G G G G G G Rpn3 Rpn13 22036573 biogrid exp G G G G G G G G G G Rpn13 Rpn7 22036573 biogrid exp G G G G G G G G G G Rpn13 Prosbeta2R1 22036573 biogrid exp G G G G G G G G G G Rpn13 FI02825p, Vacuolar H[+] ATPase M9.7 subunit b, isoform A, Vacuolar H[+] ATPase M9.7 subunit b, isoform B 14605208 biogrid,intact exp G G G G G G G G G G Rpn13 Regulatory particle triple-A ATPase 4 22036573 biogrid exp G G G G G G G G G G Prosalpha6 Rpn13 22036573 biogrid exp G G G G G G G G G G Rpn13 26S proteasome regulatory complex subunit p97, Regulatory particle non-ATPase 1 22036573 biogrid exp G G G G G G G G G G Rpn8 Rpn13 22036573 biogrid exp G G G G G G G G G G AT01380p, CG12857, isoform A Rpn13 14605208 biogrid,intact exp G Act42A Rpn13 i2d exp G G G G G G G G G G Rpn13 Rpn6 22036573 biogrid exp G G G G G G G G G G Rpn13 Prosalpha5 22036573 biogrid exp G G G G G G G G G G Rpn13 Prosbeta3 22036573 biogrid exp G G G G G G G G G G Act5C Rpn13 14605208 biogrid,intact exp G G G G G G G G G G Rpn13 AT13539p, CG11885 22036573 biogrid exp G G G G G G G G G G Rpn13 CG11870-RD 14605208 biogrid,intact exp G G G G G G bnb Rpn13 14605208 biogrid,i2d,intact exp G G G G G Rpn13 Centrocortin, isoform A, Centrocortin, isoform B, LD41224p 14605208 biogrid,i2d,intact exp G G G G G G G G G Rpn13 CG1324, isoform A, CG1324, isoform C, GH11587p 16603075 intact exp G Rpn13 Prosalpha7 22036573 biogrid exp G G G G G G G G G G Prosalpha2 Rpn13 22036573 biogrid exp G G G G G G G G G G Uch Rpn13 14605208,22036573 biogrid,i2d,intact exp G G G G G G G G G G Prosalpha4 Rpn13 22036573 biogrid exp G G G G G G G G G G Rpt6 Rpn13 22036573 biogrid exp G G G G G G G G G G Prosbeta6 Rpn13 22036573 biogrid exp G G G G G G G G G G Rpn13 Rpt3-RA 22036573 biogrid exp G G G G G G G G G G Rpn13 26S proteasome regulatory complex subunit p39A, LD17530p, Regulatory particle non-ATPase 9, isoform A, Regulatory particle non-ATPase 9, isoform B 22036573 biogrid exp G G G G G G G G G G Rpn13 CG12321-RA 22036573 biogrid exp G G G G G G G G G G Rpn13 26S proteasome regulatory complex subunit p48B, Regulatory particle triple-A ATPase 1, SD07148p 22036573 biogrid exp G G G G G G G G G G Rpn13 CG2046, GH13924p 22036573 biogrid exp G G G G G G G G G G Rpt2 Rpn13 22036573 biogrid exp G G G G G G G G G G Rpn13 Prosbeta7 22036573 biogrid exp G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7K2G1 Q7JWV5 - 14605208 - X 2 Q7K2G1 Q9V3P6 - 14605208 - X 2 Q7K2G1 Q9W4E6 - 14605208 - X 2 Q7K2G1 Q9XZ61 - 14605208 - X 2 Q9VIK6 Q7K2G1 - 14605208 - X 2 Q7K2G1 Q0KI87 - 14605208 - X 2 Q7K2G1 - 15710747 - X 2 Q7K2G1 Q9VP18 - 14605208 - X 2 Q7K2G1 Q9V3I9 - 14605208 - X 2 Q7K2G1 Q9V3P6 two hybrid 14605208 physical association X 2 Q7K2G1 Q7JWV5 two hybrid 14605208 physical association X 2 Q7K2G1 Q9XZ61 two hybrid 14605208 physical association X 2 Q7K2G1 Q9W4E6 two hybrid 14605208 physical association X 2 Q7K2G1 P29746 two hybrid 14605208 physical association X 2 Q9VIK6 Q7K2G1 two hybrid 14605208 physical association X 2 Q7K2G1 Q0KI87 two hybrid 14605208 physical association X 2 Q7K2G1 Q9V3I9 two hybrid 14605208 physical association X 2 Q7K2G1 P10987 two hybrid 14605208 physical association X 2 Q7K2G1 Q9VP18 two hybrid 14605208 physical association X 2 Q7K2G1 two hybrid 15710747 physical association X 2 Q7K2G1 Q9V3P6 two hybrid 14605208 physical association X 2 Q7K2G1 Q9XZ61 two hybrid 14605208 physical association X 2 Q7K2G1 Q9W4E6 two hybrid 14605208 physical association X 2 Q7K2G1 P29746 two hybrid 14605208 physical association X 2 Q7K2G1 Q7JWV5 two hybrid 14605208 physical association X 2 Q9VIK6 Q7K2G1 two hybrid 14605208 physical association X 2 Q7K2G1 Q0KI87 two hybrid 14605208 physical association X 2 Q7K2G1 Q9V3I9 two hybrid 14605208 physical association X 2 Q7K2G1 P10987 two hybrid 14605208 physical association X 2 Q7K2G1 Q9VP18 two hybrid 14605208 physical association X 2 Q7K2G1 Q9VRB7 two hybrid 16603075 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CG13349 VhaM9.7-b MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact) DIP_12880|BIOGRID_38896|UniProt_52204 -|bait|bait -|prey|prey CG13349 CG11885 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_72360 prey bait CG13349 Prosbeta7 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66870 bait prey CG13349 CG2046 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70526 bait prey CG13349 CG11981 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66164 prey bait CG13349 Prosbeta2 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68213 prey bait CG13349 CG1324 MI:0018(two hybrid) 16603075 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44382 prey bait CG13349 Rpt4 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66035 prey bait CG13349 CG6789 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip) BIOGRID_31215|UniProt_52202|DIP_12878 bait|bait|- prey|prey|- RpS27A CG13349 MI:0004(affinity chromatography technology) 24292889 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_77187 prey bait CG13349 CG12321-RA MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_73521 bait prey Pros25 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68045 prey bait Pros35 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65551 prey bait CG13349 Ssb-c31a MI:0686(unspecified method) 16606443 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_613619 prey bait CG13349 Cen MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_52199 bait prey CG13349 CG17331 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66474 prey bait CG13349 Rassf MI:0018(two hybrid)|MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_61972|DIP_27444 prey|- bait|- Pros26 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67249 bait prey CG13349 CG8979 MI:0004(affinity chromatography technology) 11805837 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_342540 prey bait CG13349 Prosalpha7 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67088 prey bait Mov34 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68247 bait prey CG13349 Rpn5 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68234 prey bait Pros26.4 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65634 bait prey CG13349 Rpn2 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(biogrid)|(intact)|(biogrid) DIP_10339|BIOGRID_64718|UniProt_64353|BIOGRID_30638 -|prey|bait|prey -|bait|prey|bait CG13349 Rpt3 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65444 prey bait CG13349 Tbp-1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65348 prey bait CG13349 Rpn12 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68768 prey bait CG13349 Prosalpha5 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66383 prey bait CG13349 CG15262 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact) BIOGRID_31214|DIP_12874|UniProt_52198 bait|-|bait prey|-|prey CG13349 Rpn11 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66323 prey bait CG13349 Rpn7 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67528 prey bait bnb CG13349 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact) BIOGRID_38895|DIP_12879|UniProt_52203 prey|-|prey bait|-|bait Pros29 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65900 prey bait Prosbeta5 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67920 bait prey Act5C CG13349 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|(biogrid) UniProt_52201|DIP_12877|BIOGRID_38894 prey|-|prey bait|-|bait CG13349 Rpn6 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67166 prey bait CG13349 Rpn9 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66947 prey bait CG13349 Rpt1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66674 prey bait CG13349 Prosalpha1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_72169 prey bait CG13349 Uch-L3 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(biogrid) BIOGRID_65038|UniProt_52200|BIOGRID_38893 prey|bait|bait bait|prey|prey CG11870 CG13349 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_64274|BIOGRID_30613 bait|bait prey|prey uniprotkb:(gene name) CG13349 MI:0018(two hybrid) 14605208 taxid:358() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_12876 - - CG13349 Prosbeta1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66451 prey bait CG13349 CG11870-RD MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_10264 - - Pros28.1 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66276 bait prey CG13349 CG12857 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0465(dip) BIOGRID_38236|UniProt_51237|DIP_11912 prey|bait|- bait|prey|- CG13349 Rpn1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65907 prey bait Pros45 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66026 bait prey Rpn3 CG13349 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68938 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7K2G1 P22769 RPN13 PROSALPHA4 0.126 22036573 Q7K2G1 O18413 RPN13 RPT6 0.126 22036573 Q9XYN7 Q7K2G1 PROSBETA3 RPN13 0.126 22036573 Q9XZ61 Q7K2G1 UCH-L5 RPN13 0.183 14605208 Q9XZJ4 Q7K2G1 PROSALPHA1 RPN13 0.126 22036573 Q7K2G1 Q7JWV5 RPN13 Q7JWV5 0.183 14605208 Q7K2G1 P10987 RPN13 ACT5C 0.354 14605208 Q7K2G1 P12881 RPN13 PROSALPHA6 0.126 22036573 Q7K2G1 P15357 RPN13 RPS27A 0.21 24292889 Q7K2G1 P18053 RPN13 PROSALPHA3 0.126 22036573 Q7K2G1 P25161 RPN13 RPN3 0.126 22036573 Q7K2G1 P29746 RPN13 BNB 0.354 14605208 Q7K2G1 P40301 RPN13 PROSALPHA2 0.126 22036573 Q7K2G1 Q0KI87 RPN13 Q0KI87 0.183 14605208 Q9VNA5 Q7K2G1 PROSBETA7 RPN13 0.126 22036573 Q7KLV9 Q7K2G1 RPN6 RPN13 0.126 22036573 Q9V3P6 Q7K2G1 RPN2 RPN13 0.416 22036573,14605208 Q95083 Q7K2G1 PROSALPHA5 RPN13 0.126 22036573 Q7K2G1 P26270 RPN13 RPN8 0.126 22036573 Q9V3G7 Q7K2G1 RPN7 RPN13 0.126 22036573 Q9V3H2 Q7K2G1 RPN11 RPN13 0.126 22036573 Q9V3I9 Q7K2G1 CG15262-RA RPN13 0.183 14605208 Q9V5C6 Q7K2G1 PROSALPHA7 RPN13 0.126 22036573 Q7K2G1 P40304 RPN13 PROSBETA6 0.126 22036573 Q9VIK6 Q7K2G1 CEN RPN13 0.183 14605208 Q9VP18 Q7K2G1 VHAM9.7-B RPN13 0.183 14605208 Q9VRB7 Q7K2G1 Q9VRB7 RPN13 0.183 16603075 Q9W4E6 Q7K2G1 RPN13R RPN13 0.183 14605208 Q7K2G1 P48601 RPN13 RPT2 0.126 22036573