PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG3511, isoform A, CG3511, isoform B, LD39850p eIF-2b(epsilon) 22036573 biogrid exp G G G G G G CG3511, isoform A, CG3511, isoform B, LD39850p CG17544-RA 22036573 biogrid exp G G G G G G EG:BACR7A4.11 CG3511, isoform A, CG3511, isoform B, LD39850p 22036573 biogrid exp G G G G G Conserved oligomeric Golgi complex subunit 4, COG complex subunit 4 CG3511, isoform A, CG3511, isoform B, LD39850p 22036573 biogrid exp G G G G G G CG3511, isoform A, CG3511, isoform B, LD39850p CG9925, RE70955p 14605208 biogrid,i2d,mint,intact exp G CG3511, isoform A, CG3511, isoform B, LD39850p CG12241, LD32196p 22036573 biogrid exp G G G G G G 14-3-3epsilon CG3511, isoform A, CG3511, isoform B, LD39850p ortho G G G G G G Probable peroxisomal acyl-coenzyme A oxidase 1 CG3511, isoform A, CG3511, isoform B, LD39850p ortho G G G G G G me31B CG3511, isoform A, CG3511, isoform B, LD39850p ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VFP5 Q960Q8 - 14605208 - X 2 Q95TN4 Q960Q8 affinity chromatography technology 22036573 physical association X 2 O96989 Q960Q8 affinity chromatography technology 22036573 physical association X 2 Q9VFB6 Q960Q8 affinity chromatography technology 22036573 physical association X 2 Q9W541 Q960Q8 affinity chromatography technology 22036573 physical association X 2 Q960Q8 Q9W3U0 affinity chromatography technology 22036573 physical association X 2 Q9VFP5 Q960Q8 two hybrid 14605208 direct interaction X 2 Q9VFP5 Q960Q8 two hybrid 14605208 physical association X 2 Q9VFP5 Q960Q8 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CG3511 CG7456 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68533 prey bait CG3511 eIF2B-epsilon MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68299 prey bait CG3511 CG4586 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65276 prey bait CG3511 CG9925 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_33059|MINT_14217|UniProt_49606 bait|prey|prey prey|bait|bait CG3511 CG12241 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70500 bait prey