PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Protein nutcracker unc-119 14605208 biogrid,i2d,mint,intact exp G G G G G Protein nutcracker CG6576, IP10051p 14605208 biogrid,i2d,mint,intact exp G NetB Protein nutcracker 25294943 intact exp G Protein nutcracker Visual system homeobox 2 ortholog, isoform B 14605208 biogrid,i2d exp CG11138, isoform D Protein nutcracker 14605208 biogrid,mint,intact exp G G G Protein nutcracker EG:BACR37P7.5 14605208 biogrid,i2d,mint,intact exp G Act5C Protein nutcracker 14605208 biogrid,i2d,mint,intact exp G G G G G Medea Protein nutcracker 14605208 biogrid,i2d,mint,intact exp G G G G Pp1-87B Protein nutcracker 19079254 intact exp G G G G G Protein nutcracker Ell 14605208 i2d,mint,intact exp G G G G G Protein nutcracker CG10365-RD 14605208 biogrid,i2d,mint,intact exp G G G G G Protein nutcracker Prosalpha7 21529711 biogrid exp G G G G G ATPsynC Protein nutcracker 14605208 biogrid,intact exp G G G G G LD42296p Protein nutcracker 14605208 i2d,mint,intact exp Protein nutcracker Ecdysone-inducible gene E1 14605208 i2d,mint exp SkpA Protein nutcracker 16603075,15575970 biogrid,i2d,mint,intact exp G G G G G Protein nutcracker CG5783, GH05617p 15575970 biogrid,i2d,mint,intact exp G G CG10263 Protein nutcracker i2d exp Protein nutcracker CG13067 14605208 biogrid,i2d,mint,intact exp G G G G CG12723 Protein nutcracker 14605208 biogrid,i2d,mint,intact exp Ef1alpha48D Protein nutcracker 14605208 biogrid,i2d,mint,intact exp G G G G G Protein nutcracker PI31 21529711,14605208 biogrid,i2d,mint,intact,dip exp G G G G G Ecdysone-inducible gene E1, isoform A, Ecdysone-inducible gene E1, isoform C Protein nutcracker 14605208 biogrid,i2d,intact exp CG34353, isoform A, CG34353, isoform B Protein nutcracker 14605208 biogrid exp Protein nutcracker CG15656 14605208 i2d,mint,intact exp G G Hakai, isoform F Protein nutcracker 14605208 biogrid,i2d,mint,intact exp G G G Protein nutcracker Protein nutcracker 14605208 intact exp G G G G G SkpB Protein nutcracker 16603075,15575970 biogrid,intact exp G Protein nutcracker LD22449p, Transferrin 2 14605208 biogrid,i2d,mint,intact exp G G G G CG9083 Protein nutcracker 14605208 biogrid exp RE41430p Protein nutcracker i2d exp Protein nutcracker SkpF 14605208 biogrid,i2d,mint,intact exp G Protein nutcracker Cuticular protein 72Ea 14605208 biogrid,i2d,mint,intact exp Act42A Protein nutcracker i2d exp G G G G G Prosalpha6 Protein nutcracker 21529711 intact exp G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8SX86 Q7KJ69 - 15575970 - X 2 Q8SX86 - 14605208 - X 2 Q9V637 Q8SX86 - 14605208 - X 2 Q9VJ98 Q8SX86 - 15575970 - X 2 Q8SX86 Q9W1Q0 - 14605208 - X 2 Q8SX86 Q7KJ69 two hybrid 15575970 direct interaction X 2 Q9V637 Q8SX86 affinity chromatography technology 21529711 physical association X 2 Q9V637 Q8SX86 two hybrid 14605208 direct interaction X 2 Q9VJ98 Q8SX86 two hybrid 15575970 direct interaction X 2 Q9W4B3 Q8SX86 two hybrid 14605208 direct interaction X 2 Q9V5C6 Q8SX86 affinity chromatography technology 21529711 physical association X 2 Q8SX86 Q9W1Q0 two hybrid 14605208 direct interaction X 2 Q8SX86 O77430 two hybrid 15575970 direct interaction X 2 Q8SX86 two hybrid 14605208 physical association X 2 Q9V637 Q8SX86 two hybrid 14605208 physical association X 2 Q8SX86 Q9W1Q0 two hybrid 14605208 physical association X 2 Q8SX86 Q7KJ69 two hybrid 15575970 physical association X 2 Q8SX86 Q7KJ69 two hybrid 16603075 physical association X 2 Q8SX86 Q7KJ69 two hybrid array 16603075 physical association X 2 Q9V637 Q8SX86 two hybrid 14605208 physical association X 2 Q9V637 Q8SX86 fluorescence microscopy 21529711 colocalization X 2 Q9V637 Q8SX86 anti tag coimmunoprecipitation 21529711 physical association X 2 Q9V637 Q8SX86 anti tag coimmunoprecipitation 21529711 physical association X 2 Q9VJ98 Q8SX86 two hybrid 15575970 physical association X 2 Q8SX86 anti tag coimmunoprecipitation 21529711 association C 3 Q8SX86 anti tag coimmunoprecipitation 21529711 association C 3 Q8SX86 Q9W1Q0 two hybrid 14605208 physical association X 2 Q8SX86 O77430 two hybrid 15575970 physical association X 2 Q8SX86 O77430 two hybrid 16603075 physical association X 2 Q8SX86 O77430 two hybrid array 16603075 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B skpA ntc MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970,16603075 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact)|(intact)|(intact) MINT_21604|BIOGRID_58339|UniProt_44560|UniProt_39702|UniProt_44281 bait|bait|prey|bait|prey prey|prey|bait|prey|bait ntc CG8979 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 14605208,21529711 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(biogrid)|(intact)|MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact)|(intact) UniProt_43988|UniProt_43990|UniProt_53766|BIOGRID_30142|UniProt_43989|DIP_7691|MINT_23030|BIOGRID_75627|UniProt_43992|UniProt_43991 bait|neutral component|bait|bait|bait|-|bait|bait|bait|bait prey|neutral component|prey|prey|prey|-|prey|prey|prey|prey ntc Prosalpha7 MI:0004(affinity chromatography technology) 21529711 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75626 bait prey ntc Q9V660 MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_21074 prey bait ntc CG5783 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_59068|MINT_21106|UniProt_40457 prey|prey|prey bait|bait|bait skpB ntc MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970,16603075 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(intact) UniProt_44600|BIOGRID_58338|UniProt_44364|UniProt_39701 prey|bait|prey|bait bait|prey|bait|prey ntc skpF MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|MI:0465(dip)|(intact) BIOGRID_30141|MINT_23028|DIP_7689|UniProt_53764 bait|bait|-|bait prey|prey|-|prey ntc Vsx2 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_60591 bait prey ntc Q9W4B4 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_53765|MINT_23029 bait|bait prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8SX86 O77430 NTC SKPA 0.416 16603075,15575970 Q8SX86 P12881 NTC PROSALPHA6 0.21 21529711 Q8SX86 Q7KJ69 NTC SKPB 0.416 16603075,15575970 Q9V5C6 Q8SX86 PROSALPHA7 NTC 0.21 21529711 Q9VJ98 Q8SX86 Q9VJ98 NTC 0.183 15575970 Q9W1Q0 Q8SX86 SKPF NTC 0.21 14605208 Q9V637 Q8SX86 PI31 NTC 0.722 21529711,14605208