PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Retinoblastoma-binding protein 5 homolog CG6434 22036573 biogrid exp Histone-lysine N-methyltransferase SETD1 Retinoblastoma-binding protein 5 homolog 21694722 intact exp G G G G G Retinoblastoma-binding protein 5 homolog Vps36 14605208 biogrid,i2d,mint,intact exp G G G G G Set1/Ash2 histone methyltransferase complex subunit ASH2 Retinoblastoma-binding protein 5 homolog 21694722 intact exp, ortho G G G G G wds Retinoblastoma-binding protein 5 homolog ortho G G G G G Retinoblastoma-binding protein 5 homolog Retinoblastoma-binding protein 5 homolog ortho G G G G G 14-3-3epsilon Retinoblastoma-binding protein 5 homolog ortho G G G G G BcDNA.GM09489 Retinoblastoma-binding protein 5 homolog ortho G G G G G RnrS Retinoblastoma-binding protein 5 homolog ortho G G G WD repeat-containing protein 82 Retinoblastoma-binding protein 5 homolog ortho G G G G G Retinoblastoma-binding protein 5 homolog pic ortho G G G G G Kdm4A Retinoblastoma-binding protein 5 homolog ortho G G G G Retinoblastoma-binding protein 5 homolog LD13601p, UGP, isoform A ortho Bx42 Retinoblastoma-binding protein 5 homolog ortho G G G G G Retinoblastoma-binding protein 5 homolog CG1375 ortho G G G G Retinoblastoma-binding protein 5 homolog Cfp1 ortho G G G G G Menin 1, isoform A, Menin 1, isoform C Retinoblastoma-binding protein 5 homolog ortho G G blw Retinoblastoma-binding protein 5 homolog ortho G G G G G Cullin 4, isoform A, Cullin 4, isoform B, FI05474p, LP02965p Retinoblastoma-binding protein 5 homolog ortho G G G G G cdc2c Retinoblastoma-binding protein 5 homolog ortho G G G Retinoblastoma-binding protein 5 homolog CG10418-PA ortho G G G G G Prosalpha7 Retinoblastoma-binding protein 5 homolog ortho G G G G G mof Retinoblastoma-binding protein 5 homolog ortho G Ars2 Retinoblastoma-binding protein 5 homolog ortho G G G G G His3, His3:CG31613, His3:CG33803, His3:CG33806, His3:CG33809, His3:CG33812, His3:CG33815, His3:CG33818, His3:CG33821, His3:CG33824, His3:CG33827, His3:CG33830, His3:CG33833, His3:CG33836, His3:CG33839, His3:CG33842, His3:CG33845, His3:CG33848, His3:CG33851, His3:CG33854, His3:CG33857, His3:CG33860, His3:CG33863, His3:CG33866 Retinoblastoma-binding protein 5 homolog ortho ik2-RB Retinoblastoma-binding protein 5 homolog ortho G Protein archease-like Retinoblastoma-binding protein 5 homolog ortho G G G Retinoblastoma-binding protein 5 homolog RpL23a ortho G G G G G Retinoblastoma-binding protein 5 homolog Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p ortho G G G G arm Retinoblastoma-binding protein 5 homolog ortho G G G G G Hyrax, Hyrax, isoform A, Hyrax, isoform B, LD47989p Retinoblastoma-binding protein 5 homolog ortho G G G G G Ef1alpha-like factor, isoform A, Ef1alpha-like factor, isoform B, Ef1alpha-like factor, isoform D, RE07731p Retinoblastoma-binding protein 5 homolog ortho G G G G G Utx Retinoblastoma-binding protein 5 homolog ortho G G G G G Retinoblastoma-binding protein 5 homolog Bap60 ortho G G G G G Sce Retinoblastoma-binding protein 5 homolog ortho G G G G G CG3018-PA, isoform A, Dorsal interacting protein 4, GM08377p, Lesswright, isoform A, Lesswright, isoform C, Lesswright, isoform D, RE25737p, Ubiquitin-conjugating enzyme, Ubiquitin-conjugating enzyme 9, Ubiquitin-conjugating enzyme 9 homolog Retinoblastoma-binding protein 5 homolog ortho G G G G G nero Retinoblastoma-binding protein 5 homolog ortho G G G G G O-glycosyltransferase, SD06381p, Super sex combs, isoform A, Super sex combs, isoform B, Super sex combs, isoform C Retinoblastoma-binding protein 5 homolog ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VPH8 Q9VU87 - 14605208 - X 2 Q9VPH8 affinity chromatography technology 22036573 physical association X 2 Q9VPH8 Q9VU87 two hybrid 14605208 direct interaction X 2 Q9VPH8 Q9VU87 two hybrid 14605208 physical association X 2 Q9VPH8 cosedimentation through density gradient 21694722 association C 8 Q9VPH8 tandem affinity purification 21694722 association C 8 Q9VPH8 Q9VU87 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Rbbp5 Vps36 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_53568|MINT_22836|BIOGRID_35357 bait|bait|prey prey|prey|bait Rbbp5 CG6434 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_73271 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VPH8 Q5LJZ2 RBBP5 SET1 0.21 21694722 Q9VU87 Q9VPH8 VPS36 RBBP5 0.332 14605208 Q9VPH8 Q94545 RBBP5 ASH2 0.21 21694722