PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FBXO11 PPP5 25294943 intact exp G G G G G G G G G CG3708 FBXO11 22036573 biogrid exp G Hrs FBXO11 15710747 biogrid,i2d,intact exp G G G G G G G G G SkpA FBXO11 15575970 biogrid,i2d,mint,intact exp, ortho G G G G G G G G G Trx-2 FBXO11 ortho G G G G G G G G G FBXO11 BTB (POZ) domain containing 9 ortholog, isoform A, BTB (POZ) domain containing 9 ortholog, isoform B, LD01947p ortho G G G G G G G G G FBXO11 Roc1a ortho G G G G G G G G FBXO11 Nedd8 ortho G G G G G G G G G FBXO11 CSN5 ortho G G G G G G G G G Spaghetti-squash activator, isoform C, Spaghetti-squash activator, isoform D FBXO11 ortho G G G Uba3 FBXO11 ortho G G G G G G G G G ire-1 FBXO11 ortho G G G G G G HDAC6, isoform G FBXO11 ortho G G G G G G G G G lin19 FBXO11 ortho G G G G G G G G G CSN6 FBXO11 ortho G G G G G G G G G FBXO11 APP-BP1 ortho G G G G G G G FBXO11 Ubc12 ortho G G G G G G G G G FBXO11 GDP dissociation inhibitor, isoform A, GDP dissociation inhibitor, isoform B, GDP dissociation inhibitor, isoform C, LD46767p, LP03430p ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VH60 B7FNJ7 - 15710747 - X 2 Q9VH60 O77430 two hybrid 15575970 direct interaction X 2 Q9VH60 B7FNJ7 two hybrid 15710747 direct interaction X 2 Q9VH60 Q9U1L4 affinity chromatography technology 22036573 physical association X 2 Q9VH60 O77430 two hybrid 15575970 physical association X 2 Q9VH60 B7FNJ7 two hybrid fragment pooling approach 15710747 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VH60 O77430 FBX011 SKPA 0.183 15575970 Q9VH60 Q960X8 FBX011 HRS 0.126 15710747 Q9VH81 Q9VH60 Q9VH81 FBX011 0.126 25294943