PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus mts CG2224-RA 14605208 biogrid,mint,intact exp G G G G G G CG2224-RA PPP5 25294943 intact exp G G G G G G CG2224-RA ND-23 14605208 biogrid,mint,intact exp G G G G G G RpS3A CG2224-RA 14605208 biogrid,i2d,mint,intact exp G G G G G G CG2224-RA CG12125-RB 14605208 biogrid,mint,intact exp G G G G G CG2224-RA RpL13A 14605208 biogrid,i2d,mint,intact exp G G G G G G Cep135, isoform B CG2224-RA 14605208 biogrid,i2d,mint,intact exp G G ATP-dependent chromatin assembly factor large subunit CG2224-RA 14605208 biogrid,i2d,mint,intact exp G G G G G G Fer1HCH-RD CG2224-RA 25294943 intact exp G G G G G G Spinophilin, isoform J CG2224-RA 14605208 biogrid exp G G G G Spn CG2224-RA 14605208 i2d,mint,intact exp G CG8726-RB CG2224-RA 14605208 biogrid,intact exp G G G G G G cbx CG2224-RA 14605208 biogrid,intact exp G G G G G G CG2224-RA vps24 14605208 biogrid,i2d,mint,intact exp, ortho G G G G G G Vps32 CG2224-RA 14605208 biogrid,i2d,mint,intact exp, ortho G G G G G G CG2224-RA Ubiquitin-conjugating enzyme E2 S ortho G G G G CG2224-RA CG11964, LD41978p ortho G G G G CG2224-RA GH01161p, TNF-receptor-associated factor 6 ortho G G G G G CG2224-RA Auxillin, isoform A, Auxillin, isoform B, SD05837p ortho G G G G G G CG2224-RA STAM ortho G G G G G G CG2224-RA Clc ortho G G G G G G RpS27A CG2224-RA ortho G G G G G G Ubi-p63E CG2224-RA ortho G G G G G G CG2224-RA CG15881-RA ortho G G G G G G CG32850-PA, RE41137p CG2224-RA ortho G G G G G epsin-like CG2224-RA ortho G G G G G G Farnesyl pyrophosphate synthase, GM06581p, RE52884p CG2224-RA ortho G G G G G G csw CG2224-RA ortho G G G G G Chc CG2224-RA ortho G G G G G G mRpS18c CG2224-RA ortho G G G G CG2224-RA vps2 ortho G G G G G G RpL40 CG2224-RA ortho G G G G G G CG2224-RA CG10581, IP06402p ortho G G G G G CG2224-RA CG11164, isoform A, CG11164, isoform B ortho G Receptor protein serine/threonine kinase CG2224-RA ortho G G G G G G LD28067p, Phosphotidylinositol 3 kinase 68D, isoform A, Phosphotidylinositol 3 kinase 68D, isoform C, Phosphotidylinositol 3 kinase 68D, isoform D CG2224-RA ortho G G G G G lack CG2224-RA ortho G G G G G G drk CG2224-RA ortho G G G G G G CG2224-RA Charged multivesicular body protein 5 ortho G G G G G G CG2224-RA CG2658, isoform A, CG2658, isoform C ortho G G G G G G Rpn8 CG2224-RA ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8T0Q4 Q9VA71 - 14605208 - X 2 Q9VA71 - 14605208 - X 2 Q9V9T4 Q9VA71 - 14605208 - X 2 Q9VNE9 Q9VA71 - 14605208 - X 2 Q9VA71 Q8MRL6 - 14605208 - X 2 Q960T6 Q9VA71 - 14605208 - X 2 Q9VN02 Q9VA71 - 14605208 - X 2 M9MSL4 Q9VA71 two hybrid 14605208 direct interaction X 2 Q9W3F7 Q9VA71 two hybrid 14605208 direct interaction X 2 Q8T0Q4 Q9VA71 two hybrid 14605208 direct interaction X 2 P23696 Q9VA71 two hybrid 14605208 direct interaction X 2 Q9V9T4 Q9VA71 two hybrid 14605208 direct interaction X 2 Q9VNE9 Q9VA71 two hybrid 14605208 direct interaction X 2 Q8MQL4 Q9VA71 two hybrid 14605208 direct interaction X 2 Q9VF27 Q9VA71 two hybrid 14605208 direct interaction X 2 P55830-2 Q9VA71 two hybrid 14605208 direct interaction X 2 Q9VN02 Q9VA71 two hybrid 14605208 direct interaction X 2 Q0E9E2 Q9VA71 two hybrid 14605208 direct interaction X 2 Q9VA71 two hybrid 14605208 direct interaction X 2 Q9W3F7 Q9VA71 two hybrid 14605208 physical association X 2 Q8T0Q4 Q9VA71 two hybrid 14605208 physical association X 2 P23696 Q9VA71 two hybrid 14605208 physical association X 2 Q9V9T4 Q9VA71 two hybrid 14605208 physical association X 2 Q9VNE9 Q9VA71 two hybrid 14605208 physical association X 2 P55830 Q9VA71 two hybrid 14605208 physical association X 2 A1Z782 Q9VA71 two hybrid 14605208 physical association X 2 Q9VA71 Q8MRL6 two hybrid 14605208 physical association X 2 Q960T6 Q9VA71 two hybrid 14605208 physical association X 2 Q9VF27 Q9VA71 two hybrid 14605208 physical association X 2 Q9VN02 Q9VA71 two hybrid 14605208 physical association X 2 Q0E9E2 Q9VA71 two hybrid 14605208 physical association X 2 Q9W3F7 Q9VA71 two hybrid 14605208 physical association X 2 Q8T0Q4 Q9VA71 two hybrid 14605208 physical association X 2 P23696 Q9VA71 two hybrid 14605208 physical association X 2 Q9V9T4 Q9VA71 two hybrid 14605208 physical association X 2 Q9VNE9 Q9VA71 two hybrid 14605208 physical association X 2 P55830 Q9VA71 two hybrid 14605208 physical association X 2 A1Z783 Q9VA71 two hybrid 14605208 physical association X 2 Q9VA71 Q8MRL6 two hybrid 14605208 physical association X 2 Q960T6 Q9VA71 two hybrid 14605208 physical association X 2 Q9VF27 Q9VA71 two hybrid 14605208 physical association X 2 Q9VN02 Q9VA71 two hybrid 14605208 physical association X 2 Q0E9E2 Q9VA71 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B shrb CG2224-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint) BIOGRID_32590|UniProt_25397|MINT_11715 prey|prey|prey bait|bait|bait Cep135 CG2224-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0465(dip) UniProt_61361|BIOGRID_41854|MINT_9667|DIP_17403 prey|bait|prey|- bait|prey|bait|- CG2224-RA ND23 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|MI:0471(mint)|(intact)|(biogrid) DIP_19688|MINT_11713|UniProt_25395|BIOGRID_43350 -|bait|bait|bait -|prey|prey|prey CG2224-RA CG12125-RB MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_10713|MINT_25800|BIOGRID_37521|UniProt_64733 -|bait|prey|bait -|prey|bait|prey CG2224-RA RpL13A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_40391|DIP_15172|UniProt_48466|MINT_7520 prey|-|bait|bait bait|-|prey|prey CG2224-RA vps24 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|(biogrid) MINT_11717|UniProt_25399|BIOGRID_32591 bait|bait|bait prey|prey|prey RpS3A CG2224-RA MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0465(dip)|(biogrid) UniProt_57404|MINT_11582|DIP_19540|BIOGRID_43237 prey|prey|-|bait bait|bait|-|prey CG8726 CG2224-RA MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_19691 - - Q8MKW5 CG2224-RA MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_8183 prey bait Q9V344 CG2224-RA MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_11716 prey bait CG2224-RA CG8726 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_43352|UniProt_25398 bait|bait prey|prey mts CG2224-RA MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|MI:0471(mint)|(intact)|(biogrid) DIP_19689|MINT_11714|UniProt_25396|BIOGRID_43351 -|prey|prey|prey -|bait|bait|bait CG1516 CG2224-RA MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_59819 prey bait Spn CG2224-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(intact)|MI:0471(mint) DIP_19687|UniProt_25394|MINT_11712 -|prey|prey -|bait|bait Acf1 CG2224-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|MI:0471(mint)|(biogrid) DIP_19311|UniProt_57170|MINT_11368|BIOGRID_43072 -|prey|prey|bait -|bait|bait|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VA71 Q0E9E2 CG2224-RA Q0E9E2 0.183 14605208 Q9VA71 Q8MRL6 CG2224-RA SPN 0.183 14605208 Q9VA71 Q8T0Q4 CG2224-RA SHRB 0.183 14605208 Q9VNE9 Q9VA71 RPL13A CG2224-RA 0.21 14605208 Q9VA71 P23696 CG2224-RA MTS 0.21 14605208 Q9VA71 Q960T6 CG2224-RA CEP135 0.183 14605208 Q9VA71 Q9V9T4 CG2224-RA ACF1 0.183 14605208 Q9VA83 Q9VA71 FER2LCH CG2224-RA 0.126 25294943 Q9VF27 Q9VA71 ND23 CG2224-RA 0.183 14605208 Q9VH81 Q9VA71 Q9VH81 CG2224-RA 0.126 25294943 Q9VN02 Q9VA71 VPS24 CG2224-RA 0.183 14605208 Q9W3F7 Q9VA71 CG12125-RB CG2224-RA 0.183 14605208 Q9VA71 A1Z783 CG2224-RA A1Z783 0.183 14605208 Q9VA71 P55830 CG2224-RA RPS3A 0.183 14605208