PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bruce AT19737p, GH26310p, Klhl10, isoform A, Klhl10, isoform B 17880263 biogrid,dip exp G AT19737p, GH26310p, Klhl10, isoform A, Klhl10, isoform B Cullin 3, isoform F, FI19425p1 17880263 biogrid,dip exp, ortho G AT19737p, GH26310p, Klhl10, isoform A, Klhl10, isoform B CG31251, RE67940p ortho AT19737p, GH26310p, Klhl10, isoform A, Klhl10, isoform B CG9617-RA ortho G aub AT19737p, GH26310p, Klhl10, isoform A, Klhl10, isoform B ortho G Hsp83 AT19737p, GH26310p, Klhl10, isoform A, Klhl10, isoform B ortho G AT19737p, GH26310p, Klhl10, isoform A, Klhl10, isoform B AT19737p, GH26310p, Klhl10, isoform A, Klhl10, isoform B ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6GKZ1 Q8IP45 two hybrid 17880263 direct interaction X 2 Q6GKZ1 Q9VH01 affinity chromatography technology 17880263 physical association X 2 Q9V475 Q6GKZ1 two hybrid 17880263 direct interaction X 2 Q9V475 Q6GKZ1 two hybrid 17880263 direct interaction X 2 Q6GKZ1 Q9VH01 anti tag coimmunoprecipitation 17880263 physical association X 2 Q6GKZ1 Q9VH01 anti tag coimmunoprecipitation 17880263 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B klhl10 Bruce MI:0007(anti tag coimmunoprecipitation) 17880263 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_28174 - - klhl10 Cul-3 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 17880263 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|MI:0465(dip) BIOGRID_75611|DIP_28177 prey|- bait|-