PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus lin19 Roc1b 15331761 biogrid exp G Roc1b Ubc12 14605208 biogrid,i2d,mint,intact exp G Cullin 3, isoform F, FI19425p1 Roc1b 15331761,18698375 biogrid exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VSF3 Q9NHX0 - 14605208 - X 2 Q9VSF3 Q9NHX0 two hybrid 14605208 direct interaction X 2 Q9NHX0 Q24311 affinity chromatography technology 15331761 physical association X 2 Q9NHX0 Q8IP45 affinity chromatography technology 15331761 physical association X 2 Q9NHX0 Q8IP45 affinity chromatography technology 18698375 physical association X 2 Q9VSF3 Q9NHX0 two hybrid 14605208 physical association X 2 Q9VSF3 Q9NHX0 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B lin19 Roc1b MI:0004(affinity chromatography technology) 15331761 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_77112 prey bait Roc1b Cul-3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15331761,18698375 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_77115|BIOGRID_61816 bait|bait prey|prey Roc1b CG7375 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_32167|DIP_17300|UniProt_61257|MINT_9567 bait|-|prey|prey prey|-|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NHX0 Q24311 ROC1B LIN19 0.21 15331761 Q9VSF3 Q9NHX0 UBC12 ROC1B 0.332 14605208