PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG15512 DSH3PX1 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G pros DSH3PX1 14605208 biogrid,i2d,mint,intact exp G G G G AT30481p DSH3PX1 i2d exp tmod-RC DSH3PX1 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G DSH3PX1 CG13458, GH20023p 14605208 biogrid,i2d,mint,intact exp G G G GH10884p DSH3PX1 unassigned4 intact exp DSH3PX1 BcDNA.GH10777 11773052,14605208 biogrid,i2d,mint,intact exp G G G G G G G G G DSH3PX1 CG5050-RA 14605208 biogrid,i2d,mint,intact exp G scrib DSH3PX1 14605208 biogrid exp G G G G G G G G G G Irbp DSH3PX1 15710747 biogrid,i2d,intact exp G G G Mlc2 DSH3PX1 14605208 biogrid,i2d,mint,intact exp G G G G G G SmB DSH3PX1 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G DSH3PX1 Dreadlocks, isoform B, Dreadlocks, isoform C, Dreadlocks, isoform D, LD42588p 11773052 biogrid exp G G G G G G G G G Dscam1 DSH3PX1 unassigned4 intact exp G G G G G G DSH3PX1 CG16717 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G CG3884-RB DSH3PX1 14605208 biogrid,mint,intact exp G G G Tab2-RA DSH3PX1 14605208 biogrid,intact exp G G G G G G G G CG17159 DSH3PX1 14605208 biogrid,mint,intact exp DSH3PX1 CG12393, isoform A, CG12393, isoform B, CG12393, isoform D 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G DSH3PX1 DSH3PX1 11773052,14605208 biogrid,intact exp, ortho G G G G G G G G G G Sos DSH3PX1 ortho G G G G G G G G G G DSH3PX1 aurA ortho G G DSH3PX1 UBR1 ortho G G G G G G G G DSH3PX1 emb ortho G G G G G G G G G G drk DSH3PX1 ortho G G G G G G G G G G lin19 DSH3PX1 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7JR80 Q9NCC3 - 14605208 - X 2 Q6NQZ7 Q9NCC3 - 14605208 - X 2 Q23976 Q9NCC3 - 15710747 - X 2 Q9VUL2 Q9NCC3 - 14605208 - X 2 Q9VT29 Q9NCC3 - 14605208 - X 2 Q9VA58 Q9NCC3 - 14605208 - X 2 Q8IMR7 Q9NCC3 - 14605208 - X 2 Q9VJD8 Q9NCC3 - 14605208 - X 2 Q9VMI6 Q9NCC3 - 14605208 - X 2 Q9VZI2 Q9NCC3 - 14605208 - X 2 Q05856 Q9NCC3 - 14605208 - X 2 Q9NCC3 Q7K1D9 - 14605208 - X 2 Q9NCC3 A8Y5B0 - 14605208 - X 2 Q9NCC3 - 14605208 - X 2 Q8SYH8 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q6NQZ7 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q23976 Q9NCC3 two hybrid 15710747 direct interaction X 2 Q9VUL2 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q9VT29 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q8IMR7 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q9VPU1 Q9NCC3 affinity chromatography technology 11773052 physical association X 2 Q9VPU1 Q9NCC3 two hybrid 11773052 direct interaction X 2 Q9VJD8 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q9VMI6 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q9VZI2 Q9NCC3 affinity chromatography technology 11773052 physical association X 2 Q9VZI2 Q9NCC3 pull down 11773052 direct interaction X 2 Q9VZI2 Q9NCC3 two hybrid 11773052 direct interaction X 2 Q9VZI2 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q05856 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q9NCC3 P29617 two hybrid 14605208 direct interaction X 2 Q9NCC3 Q7K1D9 two hybrid 14605208 direct interaction X 2 Q9NCC3 two hybrid 14605208 direct interaction X 2 Q9NCC3 Q9NCC3 two hybrid 11773052 direct interaction X 2 Q9NCC3 A8JRH3 two hybrid 14605208 direct interaction X 2 Q9NCC3 P18432 two hybrid 14605208 direct interaction X 2 Q9NCC3 two hybrid 14605208 physical association X 2 Q7JR80 Q9NCC3 two hybrid 14605208 physical association X 2 Q6NQZ7 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VUL2 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VAE7 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VT29 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VA59 Q9NCC3 two hybrid 14605208 physical association X 2 Q8IMR7 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VJD8 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VMI6 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VZI2 Q9NCC3 two hybrid 14605208 physical association X 2 Q05856 Q9NCC3 two hybrid 14605208 physical association X 2 Q9NCC3 P18432 two hybrid 14605208 physical association X 2 P29617-2 Q9NCC3 two hybrid 14605208 physical association X 2 Q8SYH8 Q9NCC3 two hybrid 14605208 physical association X 2 Q6NQZ7 Q9NCC3 two hybrid 14605208 physical association X 2 Q8MRP0 Q9NCC3 experimental interaction detection - physical association X 2 Q23976 Q9NCC3 two hybrid fragment pooling approach 15710747 physical association X 2 Q9VUL2 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VAE7 Q9NCC3 two hybrid 14605208 physical association X 2 Q9NCC3 Q8SZ28 two hybrid 14605208 physical association X 2 Q9VT29 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VA59 Q9NCC3 two hybrid 14605208 physical association X 2 Q8IMR7 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VJD8 Q9NCC3 two hybrid 14605208 physical association X 2 Q9VMI6 Q9NCC3 two hybrid 14605208 physical association X 2 A1Z6X2 Q9NCC3 experimental interaction detection - physical association X 2 Q9VZI2 Q9NCC3 two hybrid 14605208 physical association X 2 Q05856 Q9NCC3 two hybrid 14605208 physical association X 2 Q9NCC3 P18432 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Mlc2 SH3PX1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint) BIOGRID_32575|UniProt_57454|MINT_11628 bait|prey|prey prey|bait|bait rbcS SH3PX1 MI:0018(two hybrid) 14605208 taxid:76904() taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_44065 bait prey Irbp SH3PX1 MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_42638 bait prey CG3884 SH3PX1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_14512|UniProt_49923 bait|bait prey|prey SH3PX1 CG13458 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_28092|UniProt_52431 bait|bait prey|prey CG3884 SH3PX1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_45324 bait prey SH3PX1 Ack MI:0004(affinity chromatography technology)|MI:0398(two hybrid pooling approach)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 11773052,14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|MI:0471(mint)|(biogrid)|(intact)|(biogrid)|(biogrid) BIOGRID_61793|MINT_7893|BIOGRID_61786|UniProt_59521|BIOGRID_31797|BIOGRID_61789 bait|bait|prey|bait|prey|bait prey|prey|bait|prey|bait|prey Tab2 SH3PX1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_33692|UniProt_63062 prey|prey bait|bait Ack SH3PX1 MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45316 unspecified role unspecified role pros SH3PX1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_55531|MINT_18530|BIOGRID_41968 null|null|bait bait|bait|prey CG17159 SH3PX1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid) UniProt_50187|MINT_14775|BIOGRID_61681 prey|prey|bait bait|bait|prey SH3PX1 CG31038 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint) UniProt_26418|BIOGRID_44046|MINT_12662 prey|prey|prey bait|bait|bait SH3PX1 tmod MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_31899 prey bait SH3PX1 tmod MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_60058|MINT_8414 bait|bait prey|prey SH3PX1 Dscam MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45651 unspecified role unspecified role SmB SH3PX1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_46475|MINT_15984|UniProt_62150 bait|prey|prey prey|bait|bait SH3PX1 Q9V8T0 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_16817 bait prey SH3PX1 CG12393 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_26121|UniProt_65068 prey|prey bait|bait SH3PX1 dock MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11773052 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_61794|BIOGRID_61785 bait|prey prey|bait SH3PX1 CG16717 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_9231|UniProt_60908 bait|bait prey|prey scrib SH3PX1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_26448|MINT_12691 prey|prey bait|bait SH3PX1 CG12393 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_37730 prey bait SH3PX1 CG5050-RA MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_15717|BIOGRID_33382|UniProt_61868 prey|prey|prey bait|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NCC3 Q05856 SH3PX1 SMB 0.21 14605208 Q9NCC3 A1Z6X2 SH3PX1 DSCAM1 0.126 unassigned4 Q9NCC3 Q23976 SH3PX1 IRBP 0.126 15710747 Q9NCC3 Q8MRP0 SH3PX1 ACK 0.126 unassigned4 Q9NCC3 Q8SZ28 SH3PX1 Q8SZ28 0.183 14605208 Q9VAE7 Q9NCC3 Q9VAE7 SH3PX1 0.183 14605208 Q9VJD8 Q9NCC3 CG5050-RA SH3PX1 0.183 14605208 Q9VMI6 Q9NCC3 Q9VMI6 SH3PX1 0.183 14605208 Q9NCC3 Q8SYH8 SH3PX1 CG17159 0.183 14605208 Q9NCC3 Q6NQZ7 SH3PX1 TAB2 0.183 14605208 Q9NCC3 P18432 SH3PX1 MLC2 0.21 14605208 Q9NCC3 P29617 SH3PX1 PROS 0.183 14605208 Q9VA59 Q9NCC3 TMOD SH3PX1 0.183 14605208 Q9VT29 Q9NCC3 Q9VT29 SH3PX1 0.183 14605208 Q9VUL2 Q9NCC3 Q9VUL2 SH3PX1 0.183 14605208 Q9VZI2 Q9NCC3 ACK SH3PX1 0.183 14605208