PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Roc2-RA CG30409, isoform A, CG30409, isoform B 14605208 biogrid,intact exp CG7763, isoform A, CG7763, isoform B Roc2-RA 14605208 biogrid,intact exp G G Homer, isoform E Roc2-RA 14605208 biogrid,intact exp G G G G G Roc2-RA Cullin 5, FI20194p1 15331761,18698375 biogrid exp, ortho G G G G G G G G G G CkIIbeta Roc2-RA ortho G G G G G G G G G G Bgb Roc2-RA ortho G G G G G Roc2-RA TER94 ortho G G G G G G G G G G Roc2-RA Ubc12 ortho G G G G G G G G G G slmb Roc2-RA ortho G G G G G G G G G Roc2-RA RE54550p, Rab40, isoform B ortho G G G G G G G G G Roc2-RA Cullin 2, isoform A, Cullin 2, isoform B, LD36177p ortho G G G G G G G G G G eff Roc2-RA ortho G G G G G G G G G G Cullin 4, isoform A, Cullin 4, isoform B, FI05474p, LP02965p Roc2-RA ortho G G G G G G G G G G Cyt-c-p Roc2-RA ortho G G G G G G G G G G CG30493 Roc2-RA ortho G G Roc2-RA Roc2-RA ortho G G G G G G G G G G Roc2-RA Skp2, isoform A, Skp2, isoform E ortho G G G G Elongin C, isoform A, Elongin C, isoform B, RE05591p, RH71704p Roc2-RA ortho G G G G G G G G G G Roc2-RA MAT1 ortho G G G G G G G G G G lin19 Roc2-RA ortho G G G G G G G G G G Roc2-RA Nedd4 ortho G G G G G G G G G Roc2-RA Cullin 3, isoform F, FI19425p1 ortho G G G G G G G G G G gus Roc2-RA ortho G G G G G G G G G G CkIIalpha Roc2-RA ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9W1R9 Q7JWH5 - 14605208 - X 2 Q9VM94 Q7JWH5 - 14605208 - X 2 A1Z8L7 Q7JWH5 - 14605208 - X 2 Q9W1R9 Q7JWH5 two hybrid 14605208 direct interaction X 2 Q7JWH5 Q9VAQ0 affinity chromatography technology 15331761 physical association X 2 Q7JWH5 M9PB54 two hybrid 14605208 direct interaction X 2 Q7JWH5 Q9VAQ0 affinity chromatography technology 18698375 physical association X 2 A1Z8L7 Q7JWH5 two hybrid 14605208 direct interaction X 2 Q9W1R9 Q7JWH5 two hybrid 14605208 physical association X 2 Q9VM94 Q7JWH5 two hybrid 14605208 physical association X 2 A1Z8L7 Q7JWH5 two hybrid 14605208 physical association X 2 O96607 Q7JWH5 two hybrid 14605208 physical association X 2 Q9W1R9 Q7JWH5 two hybrid 14605208 physical association X 2 A1Z8L7 Q7JWH5 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Roc2 CG7763 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact) DIP_25642|BIOGRID_47488|UniProt_52886 -|prey|prey -|bait|bait Roc2 CG30409 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact) BIOGRID_32742|DIP_20419|UniProt_26133 prey|-|bait bait|-|prey Roc2 Cul-5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15331761,18698375 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_77116|BIOGRID_61817 bait|bait prey|prey homer Roc2 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_55083 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7JWH5 A1Z8L7 ROC2 A1Z8L7 0.183 14605208 Q7JWH5 O96607 ROC2 HOMER 0.183 14605208 Q9W1R9 Q7JWH5 Q9W1R9 ROC2 0.183 14605208