PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O13790 P87053 - 15660136 - X 2 A0A024R1Z1 O13790 pull down 11337588 direct interaction X 2 O14170 O13790 affinity chromatography technology 23535663 physical association X 2 O14170 O13790 affinity chromatography technology 9990507 physical association X 2 O14170 O13790 affinity chromatography technology 12167173 physical association X 2 O13895 O13790 affinity chromatography technology 23535663 physical association X 2 P61201-2 O13790 enzymatic study 24421388 direct interaction X 2 O13959 O13790 affinity chromatography technology 23535663 physical association X 2 O13959 O13790 affinity chromatography technology 23535663 physical association X 2 O13959 O13790 affinity chromatography technology 11337588 physical association X 2 O13959 O13790 affinity chromatography technology 12167173 physical association X 2 O13959 O13790 affinity chromatography technology 12167173 physical association X 2 O74531 O13790 affinity chromatography technology 23535663 physical association X 2 O74531 O13790 affinity chromatography technology 19748355 physical association X 2 O13790 O94454 enzymatic study 12183637 direct interaction X 2 O13790 O94454 affinity chromatography technology 12183637 physical association X 2 O13790 Q9HFR0 affinity chromatography technology 23535663 physical association X 2 O13790 O94454 affinity chromatography technology 23535663 physical association X 2 O13790 Q13098-5 enzymatic study 24421388 direct interaction X 2 O13790 Q9UNS2 enzymatic study 24421388 direct interaction X 2 O13790 Q9HFR0 affinity chromatography technology 11337588 physical association X 2 O13790 P0CG72 pull down 11337588 direct interaction X 2 P87060 O13790 affinity chromatography technology 23535663 physical association X 2 P87060 O13790 affinity chromatography technology 10880460 physical association X 2 P87060 O13790 affinity chromatography technology 12167173 physical association X 2 Q09855 O13790 affinity chromatography technology 23535663 physical association X 2 Q9P7W4 O13790 affinity chromatography technology 23535663 physical association X 2 Q9P7W4 O13790 affinity chromatography technology 23535663 physical association X 2 Q9P7W4 O13790 affinity chromatography technology 23535663 physical association X 2 Q9P7W4 O13790 affinity chromatography technology 19748355 physical association X 2 O74381 O13790 affinity chromatography technology 23535663 physical association X 2 O74381 O13790 affinity chromatography technology 19748355 physical association X 2 Q7L5N1 O13790 enzymatic study 24421388 direct interaction X 2 Q9Y709 O13790 affinity chromatography technology 23535663 physical association X 2 Q9Y709 O13790 affinity chromatography technology 11337588 physical association X 2 Q9Y709 O13790 affinity chromatography technology 15147268 physical association X 2 Q9Y709 O13790 affinity chromatography technology 12167173 physical association X 2 Q9Y709 O13790 affinity chromatography technology 15555586 physical association X 2 O14399 O13790 affinity chromatography technology 11854407 physical association X 2 O14399 O13790 affinity chromatography technology 10880460 physical association X 2 Q9UBW8 O13790 enzymatic study 24421388 direct interaction X 2 Q99627-2 O13790 enzymatic study 24421388 direct interaction X 2 A0A024R7W9 O13790 enzymatic study 24421388 direct interaction X 2 A0A024R7W9 O13790 enzymatic study 11337588 direct interaction X 2 Q10223 O13790 affinity chromatography technology 23535663 physical association X 2 Q10223 O13790 affinity chromatography technology 17016471 physical association X 2 O42980 O13790 pull down 15769255 direct interaction X 2 O94308 O13790 affinity chromatography technology 12183637 physical association X 2 O94308 O13790 affinity chromatography technology 23535663 physical association X 2 O13790 O13790 affinity chromatography technology 23535663 physical association X 2 O13790 P87053 affinity chromatography technology 23535663 physical association X 2 O13790 P87053 affinity chromatography technology 23535663 physical association X 2 O13790 O13790 enzymatic study 11337588 direct interaction X 2 O13790 O74991 affinity chromatography technology 11809834 physical association X 2 O13790 O74991 affinity chromatography technology 11809834 physical association X 2 O13790 P87053 affinity chromatography technology 15660136 physical association X 2 O13790 P87053 affinity chromatography technology 19748355 physical association X 2 O13790 O74991 affinity chromatography technology 19748355 physical association X 2 O13612 O13790 pull down 15769255 direct interaction X 2 O14235 O13790 affinity chromatography technology 23535663 physical association X 2 O13790 anti bait coimmunoprecipitation 12167173 association C 3 O14170 O13790 anti tag coimmunoprecipitation 9990507 physical association X 2 O13790 anti bait coimmunoprecipitation 12167173 association C 4 O13790 anti bait coimmunoprecipitation 12167173 association C 4 O13790 anti bait coimmunoprecipitation 12167173 association C 4 O13790 anti bait coimmunoprecipitation 12167173 association C 5 O13790 anti bait coimmunoprecipitation 12167173 association C 5 O13790 anti bait coimmunoprecipitation 12167173 association C 5 O13790 anti bait coimmunoprecipitation 12167173 association C 5 Q9Y709 O13790 anti bait coimmunoprecipitation 15147268 physical association X 2 Q10223 O13790 anti tag coimmunoprecipitation 17016471 physical association X 2 O13790 O74991 anti tag coimmunoprecipitation 11809834 physical association X 2 O13790 O74991 anti tag coimmunoprecipitation 11809834 physical association X 2 O13790 P87053 anti tag coimmunoprecipitation 15660136 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CUL1 CUL1 11337588 0415 LC CUL1 CSN5 12183637,12183637 0415,0004 LC NEP2 CUL1 15769255 0096 LC CUL1 CUL1 23535663 0004 LC CUL1 CSN4 23535663 0004 LC CUL1 PIP1 12167173,11337588,12167173,23535663 0006,0004,0004,0004 LC CUL1 POP2 9990507,12167173,9990507,23535663,12167173 0007,0006,0004,0004,0004 LC CUL1 POF5 23535663 0004 LC CUL1 UBL1 10880460,11854407 0004,0004 LC CUL1 NEP1 15769255 0096 LC CUL1 POF9 19748355,23535663 0004,0004 LC CUL1 POF7 19748355,23535663 0004,0004 LC CUL1 POF3 19748355,11809834,11809834 0004,0007,0004 LC CUL1 CSN1 12183637,23535663 0004,0004 LC CUL1 CSN5 12183637,12183637,23535663 0415,0004,0004 LC CUL1 UBI4 11337588 0096 LC CUL1 POF1 19748355,23535663,15660136,15660136 0004,0004,0007,0004 LC CUL1 POP1 12167173,23535663,10880460,12167173 0006,0004,0004,0004 LC CUL1 POF11 23535663 0004 LC CUL1 POF14 17016471,17016471,17016471,23535663 0004,0109,0007,0004 LC CUL1 CSN2 11337588,23535663 0004,0004 LC CUL1 POF10 19748355,23535663 0004,0004 LC CUL1 SKP1 15147268,15147268,11337588,15555586,12167173,23535663,12167173 0006,0004,0004,0004,0004,0004,0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O42980 O13790 NEP1 CUL1 0.309 15769255 Q10223 O13790 POF14 CUL1 0.396 17016471,23535663 O94454 O13790 CSN5 CUL1 0.569 23535663,12183637 Q9Y709 O13790 SKP1 CUL1 0.808 15147268,23535663,11337588,12167173,15555586 Q92905 O13790 COPS5 CUL1 0.523 24421388,11337588 O14399 O13790 UBL1 CUL1 0.376 10880460,11854407 O13790 O13790 CUL1 CUL1 0.49 11337588,23535663 O94308 O13790 CSN1 CUL1 0.376 12183637,23535663 P87053 O13790 POF1 CUL1 0.692 23535663,15660136,19748355 O13959 O13790 PIP1 CUL1 0.757 12167173,23535663,11337588 O14170 O13790 POP2 CUL1 0.757 23535663,12167173,9990507 O13790 O13612 CUL1 NEP2 0.309 15769255 O13895 O13790 CSN4 CUL1 0.21 23535663 O14235 O13790 POF5 CUL1 0.21 23535663 O74381 O13790 POF9 CUL1 0.376 19748355,23535663 O74531 O13790 POF7 CUL1 0.376 19748355,23535663 O74991 O13790 POF3 CUL1 0.507 11809834,19748355 P0CG72 O13790 UBI4 CUL1 0.309 11337588 P49427 O13790 CDC34 CUL1 0.309 11337588 P87060 O13790 POP1 CUL1 0.61 10880460,23535663,12167173 Q09855 O13790 POF11 CUL1 0.21 23535663 Q9HFR0 O13790 CSN2 CUL1 0.376 11337588,23535663 Q9P7W4 O13790 POF10 CUL1 0.507 19748355,23535663