PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q09715 Q9P6Q6 two hybrid 12637515 direct interaction X 2 Q09715 Q9P6Q6 pull down 12637515 direct interaction X 2 Q09715 Q10134 affinity chromatography technology 14668334 physical association X 2 Q09715 Q10134 affinity chromatography technology 15866870 physical association X 2 Q09715 O60184 affinity chromatography technology 15632072 physical association X 2 Q09715 Q10156 affinity chromatography technology 20200159 physical association X 2 Q09715 Q10156 enzymatic study 20200159 direct interaction X 2 Q09715 Q10156 pull down 20200159 direct interaction X 2 Q09715 Q10134 two hybrid 21421748 direct interaction X 2 Q9UUG8 Q09715 affinity chromatography technology 12221110 physical association X 2 Q9UUG8 Q09715 affinity chromatography technology 12221110 physical association X 2 Q9UUG8 Q09715 affinity chromatography technology 15632072 physical association X 2 Q09715 O74954 affinity chromatography technology 22540037 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality TUP11 TUP11 26771498 0018 HT TUP11 FEP1 21421748 0018 LC TUP11 LKH1 20200159,20200159,20200159 0096,0415,0004 LC TUP11 PCT1 12637515,12637515 0096,0018 LC SSN6 TUP11 15632072 0004 LC CBF11 TUP11 22540037 0004 LC TUP11 FEP1 15866870,14668334 0004,0004 LC TUP11 LKH1 20200159,20200159,20200159 0096,0415,0004 LC TUP11 PCT1 12637515,12637515 0096,0018 LC TUP11 TUP12 15632072,12221110 0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q09715 Q09715 TUP11 TUP11 0.21 26771498 Q9UUG8 Q09715 TUP12 TUP11 0.507 12221110,15632072 Q10134 Q09715 FEP1 TUP11 0.569 14668334,15866870,21421748 Q09715 O60184 TUP11 SSN6 0.21 15632072 Q09715 O74954 TUP11 CBF11 0.126 22540037 Q10156 Q09715 LKH1 TUP11 0.623 20200159 Q9P6Q6 Q09715 PCT1 TUP11 0.523 12637515