PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O13916 - 12477395 - C 13 O13916 O74358 affinity chromatography technology 12477395 physical association X 2 O13916 O59767 affinity chromatography technology 18556659 physical association X 2 O13916 O42839 affinity chromatography technology 12477395 physical association X 2 O13916 O42839 affinity chromatography technology 16950791 physical association X 2 O13916 P41889 affinity chromatography technology 16950791 physical association X 2 O13916 P41889 affinity chromatography technology 16950791 physical association X 2 O13916 P04551 enzymatic study 16950791 direct interaction X 2 O13916 P41889 two hybrid 16950791 direct interaction X 2 O13916 P41889 biochemical 16950791 colocalization X 2 O13916 O42839 affinity chromatography technology 18082611 physical association X 2 O13916 P41889 x-ray crystallography 20924356 association X 2 O13916 O42839 affinity chromatography technology 18556659 physical association X 2 O13916 tandem affinity purification 12477395 association C 13 O13916 tandem affinity purification 12477395 association C 13 O13916 P41889 x-ray crystallography 20924356 direct interaction X 2 O13916 P41889 light scattering 20924356 direct interaction X 2

PPI - HINT Gene A Gene B PMID Method Quality HCN1 CDC2 16950791 0415 LC HCN1 CUT9 26771498,20924356,20924356,16950791,16950791,16950791 0018,0114,0067,0004,0401,0018 HT,LC HCN1 CUT20 12477395,18082611,18556659,16950791,12477395 0004,0004,0004,0004,0676 LC HCN1 MAD3 18556659 0004 LC HCN1 APC13 12477395,12477395 0004,0676 LC HCN1 CUT9 16950791,16950791,16950791 0004,0401,0018 LC