PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O13895 Q09760 enzymatic study 11504566 direct interaction X 2 Q09760 O74881 affinity chromatography technology 14527422 physical association X 2 Q09760 Q10225 affinity chromatography technology 14527422 physical association X 2 Q09760 O60079 affinity chromatography technology 12718879 physical association X 2 Q09760 O74881 affinity chromatography technology 14527422 physical association X 2 Q09760 O94454 enzymatic study 11504566 direct interaction X 2 P46595 Q09760 affinity chromatography technology 14527422 physical association X 2 O42980 Q09760 pull down 15769255 direct interaction X 2 Q09760 O74778 affinity chromatography technology 14527422 physical association X 2 Q09760 O13959 affinity chromatography technology 14527422 physical association X 2 Q09760 O14399 affinity chromatography technology 14527422 physical association X 2 Q09760 O14399 enzymatic study 11504566 direct interaction X 2 Q09760 O94308 enzymatic study 11504566 direct interaction X 2 Q09760 pull down 14527422 association C 3 Q09760 O74881 pull down 14527422 physical association X 2 Q09760 Q10225 anti tag coimmunoprecipitation 14527422 physical association X 2 Q09760 Q10225 pull down 14527422 physical association X 2 Q09760 Q10225 pull down 14527422 physical association X 2 Q09760 pull down 14527422 association C 3 Q09760 anti tag coimmunoprecipitation 14527422 association C 3 Q09760 pull down 14527422 association C 13 Q09760 O74778 pull down 14527422 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CSN4 CUL3 11504566 0415 LC UBL1 CUL3 11504566 0415 LC CSN1 CUL3 11504566 0415 LC CSN5 CUL3 11504566 0415 LC PIP1 CUL3 14527422,14527422 0004,0096 LC UBL1 CUL3 14527422,14527422 0004,0096 LC RPT1 CUL3 14527422 0096 LC NEP1 CUL3 15769255 0096 LC UBP12 CUL3 12718879 0004 LC CCT3 CUL3 14527422 0096 LC RPN2 CUL3 14527422 0096 LC BTB2 CUL3 14527422,14527422,14527422 0004,0096,0007 LC BTB1 CUL3 14527422,14527422 0004,0096 LC MTS2 CUL3 14527422 0096 LC LET1 CUL3 14527422 0096 LC UBC4 CUL3 14527422,14527422 0004,0096 LC CCT4 CUL3 14527422 0096 LC CCT8 CUL3 14527422 0096 LC ANC1 CUL3 14527422 0096 LC CUL3 BTB3 14527422,14527422,14527422 0004,0096,0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q09760 O13959 CUL3 PIP1 0.21 14527422 Q09760 O74881 CUL3 BTB1 0.376 14527422 Q09760 P46595 CUL3 UBC4 0.21 14527422 Q09760 O42980 CUL3 NEP1 0.309 15769255 Q10225 Q09760 BTB3 CUL3 0.21 14527422 Q09760 O60079 CUL3 UBP12 0.21 12718879 Q09760 O74778 CUL3 BTB2 0.21 14527422 Q09760 O94308 CUL3 CSN1 0.309 11504566 Q09760 O94454 CUL3 CSN5 0.309 11504566 Q09760 O13895 CUL3 CSN4 0.309 11504566 Q09760 O14399 CUL3 UBL1 0.454 14527422,11504566