PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P41878 - 16096059 - C 5 Q9UQY2 P41878 affinity chromatography technology 20838651 physical association X 2 Q9USR1 P41878 pull down 21091378 direct interaction X 2 Q10335 P41878 affinity chromatography technology 20838651 physical association X 2 P36612 P41878 affinity chromatography technology 20838651 physical association X 2 P41836 P41878 affinity chromatography technology 20838651 physical association X 2 O74894 P41878 affinity chromatography technology 22307589 physical association X 2 O74894 P41878 affinity chromatography technology 20838651 physical association X 2 O14126 P41878 affinity chromatography technology 20838651 physical association X 2 Q9Y7Y6 P41878 affinity chromatography technology 20838651 physical association X 2 O59770 P41878 affinity chromatography technology 20838651 physical association X 2 Q09682 P41878 affinity chromatography technology 20838651 physical association X 2 Q9UT97 P41878 affinity chromatography technology 20838651 physical association X 2 Q9UUB6 P41878 pull down 15533439 direct interaction X 2 Q9UUB6 P41878 affinity chromatography technology 20838651 physical association X 2 Q9UUB6 P41878 affinity chromatography technology 20838651 physical association X 2 O60125 P41878 affinity chromatography technology 23779158 physical association X 2 O60125 P41878 pull down 24497846 direct interaction X 2 Q9P7S2 P41878 affinity chromatography technology 20838651 physical association X 2 P41878 O14250 affinity chromatography technology 20838651 physical association X 2 P41878 Q9USQ9 affinity chromatography technology 20838651 physical association X 2 Q09720 P41878 affinity chromatography technology 20838651 physical association X 2 P40236 P41878 affinity chromatography technology 24055157 physical association X 2 O43063 P41878 affinity chromatography technology 20838651 physical association X 2 Q9P7I7 P41878 affinity chromatography technology 25002536 physical association X 2 O59739 P41878 pull down 24497846 direct interaction X 2 Q9USM1 P41878 affinity chromatography technology 20838651 physical association X 2 O42897 P41878 affinity chromatography technology 22307589 physical association X 2 O42897 P41878 affinity chromatography technology 20838651 physical association X 2 O94444 P41878 affinity chromatography technology 12783882 physical association X 2 O94444 P41878 affinity chromatography technology 20838651 physical association X 2 O74762 P41878 affinity chromatography technology 20838651 physical association X 2 P38937 P41878 affinity chromatography technology 16096059 physical association X 2 O42931 P41878 affinity chromatography technology 20838651 physical association X 2 O94579 P41878 affinity chromatography technology 20838651 physical association X 2 Q9Y7T8 P41878 affinity chromatography technology 20838651 physical association X 2 Q09841 P41878 affinity chromatography technology 20838651 physical association X 2 P41878 O74954 affinity chromatography technology 22540037 physical association X 2 P41878 P87048 affinity chromatography technology 9727008 physical association X 2 P41878 P87048 imaging technique 9822592 colocalization X 2 P41878 P87048 biochemical 9727008 colocalization X 2 P41878 Q9P7A1 pull down 21091378 direct interaction X 2 P41878 Q9UTM3 affinity chromatography technology 20838651 physical association X 2 P41878 P87048 affinity chromatography technology 20838651 physical association X 2 P41878 Q9US13 affinity chromatography technology 20838651 physical association X 2 P41878 O74440 affinity chromatography technology 20838651 physical association X 2 P41878 O94517 affinity chromatography technology 20838651 physical association X 2 P41878 Q10329 affinity chromatography technology 20838651 physical association X 2 P40235 P41878 affinity chromatography technology 24055157 physical association X 2 P50524 P41878 affinity chromatography technology 20838651 physical association X 2 O74445 P41878 affinity chromatography technology 20838651 physical association X 2 P30655 P41878 affinity chromatography technology 20838651 physical association X 2 Q9P7H8 P41878 affinity chromatography technology 20838651 physical association X 2 P38937 P41878 pull down 16096059 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality BDC1 RPN11 26771498 0018 HT RPN11 RPN1 9727008,9727008 0401,0004 LC TBP1 RPN11 20838651 0004 LC O14250 RPN11 20838651 0004 LC RPN3 RPN11 20838651,22307589 0004,0004 LC RPT1 RPN11 20838651 0004 LC PRE3 RPN11 20838651 0004 LC BAG102 RPN11 24497846 0096 LC PRE10 RPN11 20838651 0004 LC BAG101 RPN11 23779158,24497846 0004,0096 LC RPN8 RPN11 20838651 0004 LC RPT4 RPN11 20838651 0004 LC RPN2 RPN11 20838651 0004 LC RPT3 RPN11 20838651,22307589 0004,0004 LC CBF11 RPN11 22540037 0004 LC RPN10 RPN11 12783882,20838651 0004,0004 LC O94517 RPN11 20838651 0004 LC PRE8 RPN11 20838651 0004 LC PTS1 RPN11 20838651 0004 LC MTS2 RPN11 20838651 0004 LC CUT8 RPN11 16096059,16096059 0004,0096 LC LET1 RPN11 20838651 0004 LC RPN11 RPN12 20838651 0004 LC RPN11 RPN1 9727008,20838651,9822592,9727008 0401,0004,0428,0004 LC RPN11 Q09682 20838651 0004 LC RPN11 Q09720 20838651 0004 LC RPN11 PUP1 20838651 0004 LC RPN11 PRE6 20838651 0004 LC RPN11 RPN7 20838651 0004 LC RPN11 Q9P7A1 21091378 0096 LC RPN11 ECM29 20838651 0004 LC RPN11 Q9P7I7 25002536 0004 LC RPN11 RPN6 20838651 0004 LC RPN11 PAM1 20838651 0004 LC RPN11 RPN9 20838651 0004 LC RPN11 Q9USM1 20838651 0004 LC RPN11 Q9USQ9 20838651 0004 LC RPN11 TXL1 21091378 0096 LC RPN11 PUP2 20838651 0004 LC RPN11 RPN501|RPN502 20838651 0004 LC RPN11 UCH2 15533439,20838651 0096,0004 LC RPN11 PUP3 20838651 0004 LC RPN11 Q9Y7Y6 20838651 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P41878 O59739 RPN11 BAG102 0.309 24497846 P41878 O60125 RPN11 BAG101 0.309 24497846 P41878 O74954 RPN11 CBF11 0.126 22540037 P41878 O42897 RPN11 RPN3 0.309 20838651,22307589 P41878 O74894 RPN11 RPT3 0.309 20838651,22307589 P41878 P38937 RPN11 CUT8 0.21 16096059 Q9P7A1 P41878 Q9P7A1 RPN11 0.309 21091378 Q9P7I7 P41878 Q9P7I7 RPN11 0.126 25002536 Q9USR1 P41878 TXL1 RPN11 0.309 21091378 Q9UUB6 P41878 UCH2 RPN11 0.472 20838651,15533439 P87048 P41878 RPN1 RPN11 0.472 20838651,9822592,9727008 P50524 P41878 RPN12 RPN11 0.126 20838651 P41878 O14126 RPN11 TBP1 0.126 20838651 P41878 O74440 RPN11 RPN8 0.126 20838651 P41878 O74350 RPN11 BDC1 0.183 26771498 P41878 O42931 RPN11 RPT1 0.126 20838651 P41878 O14250 RPN11 O14250 0.126 20838651 P41878 O59770 RPN11 PRE10 0.126 20838651 P41878 O43063 RPN11 PRE3 0.126 20838651 P41878 P41836 RPN11 LET1 0.126 20838651 P41878 O74762 RPN11 RPN2 0.126 20838651 P41878 O74445 RPN11 RPT4 0.126 20838651 P41878 O94444 RPN11 RPN10 0.309 20838651,12783882 P41878 O94517 RPN11 O94517 0.126 20838651 P41878 P36612 RPN11 MTS2 0.126 20838651 P41878 O94579 RPN11 PRE8 0.126 20838651 P41878 P30655 RPN11 PTS1 0.126 20838651 P41878 P0CU17 RPN11 RPN501 0.126 20838651 P41878 P0CU18 RPN11 RPN502 0.126 20838651 Q10335 P41878 RPN7 RPN11 0.126 20838651 Q10329 P41878 PRE6 RPN11 0.126 20838651 Q09841 P41878 PUP1 RPN11 0.126 20838651 Q09682 P41878 Q09682 RPN11 0.126 20838651 Q09720 P41878 Q09720 RPN11 0.126 20838651 Q9USQ9 P41878 Q9USQ9 RPN11 0.126 20838651 Q9P7S2 P41878 RPN6 RPN11 0.126 20838651 Q9P7H8 P41878 ECM29 RPN11 0.126 20838651 Q9USM1 P41878 Q9USM1 RPN11 0.126 20838651 Q9UQY2 P41878 PAM1 RPN11 0.126 20838651 Q9US13 P41878 RPN9 RPN11 0.126 20838651 Q9Y7T8 P41878 PUP3 RPN11 0.126 20838651 Q9UT97 P41878 PUP2 RPN11 0.126 20838651 Q9Y7Y6 P41878 Q9Y7Y6 RPN11 0.126 20838651