PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O14122 Q10426 - 16127433 - X 2 O60016 O14122 - 16127433 - X 2 O14122 - 16127433 - C 3 O14122 Q10426 pull down 24449894 direct interaction X 2 O14122 Q10426 pull down 24449894 direct interaction X 2 O14122 Q10426 affinity chromatography technology 16127433 physical association X 2 O14122 Q10426 affinity chromatography technology 16024659 physical association X 2 O14122 Q10426 affinity chromatography technology 17114925 physical association X 2 O13807 O14122 affinity chromatography technology 18794354 physical association X 2 O94276 O14122 affinity chromatography technology 20211136 physical association X 2 O60016 O14122 imaging technique 16127433 colocalization X 2 O60016 O14122 affinity chromatography technology 16127433 physical association X 2 Q10990 O14122 affinity chromatography technology 16252005 physical association X 2 O42980 O14122 pull down 15769255 direct interaction X 2 O74560 O14122 pull down 24449894 direct interaction X 2 O74560 O14122 pull down 24449894 direct interaction X 2 O74560 O14122 two hybrid 25090107 direct interaction X 2 O74560 O14122 two hybrid 16157682 direct interaction X 2 O74560 O14122 affinity chromatography technology 17114925 physical association X 2 O14122 tandem affinity purification 16252005 association C 10 O14122 pull down 20211136 physical association C 11 O14122 tandem affinity purification 16024659 association C 7 O14122 Q10426 anti tag coimmunoprecipitation 16127433 physical association X 2 O14122 Q10426 anti tag coimmunoprecipitation 16127433 physical association X 2 O60016 O14122 anti tag coimmunoprecipitation 16127433 physical association X 2 O60016 O14122 tandem affinity purification 16127433 physical association X 2 O60016 O14122 anti tag coimmunoprecipitation 16127433 physical association X 2 O14122 tandem affinity purification 18957202 association C 3 Q9HDV4 O14122 anti tag coimmunoprecipitation 18957202 physical association X 2 O74560 O14122 two hybrid 16157682 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CUL4 CLR4 16127433,16127433,16127433,16127433,16127433 0007,0428,0019,0004,0676 LC CUL4 O60130 26771498 0018 HT CUL4 RAF2 25090107,16157682 0018,0018 LC CUL4 RIK1 16127433,16127433,16127433 0007,0004,0019 LC DDB1 CUL4 18794354 0004 LC CUL4 NEP1 15769255 0096 LC CUL4 CLR4 16127433,16127433,16127433,16127433,16127433 0007,0428,0019,0004,0676 LC CUL4 RAF2 17114925,24449894 0004,0096 LC CUL4 RAF1 18957202 0676 LC CUL4 O94276 20211136,20211136 0004,0096 LC CUL4 RIK1 16024659,16024659,24449894,16127433,17114925,16127433,16127433 0676,0004,0096,0007,0004,0004,0019 LC CUL4 CDT2 16252005,16252005 0676,0004 LC CUL4 LID2 18957202 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O42980 O14122 NEP1 CUL4 0.309 15769255 Q10990 O14122 CDT2 CUL4 0.21 16252005 Q9HDV4 O14122 LID2 CUL4 0.21 18957202 O74910 O14122 RAF1 CUL4 0.21 18957202 O60016 O14122 CLR4 CUL4 0.309 16127433 O94276 O14122 O94276 CUL4 0.376 20211136 O14122 O13807 CUL4 DDB1 0.21 18794354 O60130 O14122 O60130 CUL4 0.183 26771498 O74560 O14122 RAF2 CUL4 0.876 25090107,16157682,24449894,17114925 Q10426 O14122 RIK1 CUL4 0.765 24449894,16024659,16127433,17114925