PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O94646 - 12738880 - C 12 O14198 O94646 biochemical 18310102 association X 2 O14198 O94646 x-ray crystallography 18381891 association X 2 O14198 O94646 pull down 18381891 direct interaction X 2 Q9HE02 O94646 affinity chromatography technology 12738880 physical association X 2 O94646 Q10477 biochemical 18310102 association X 2 O94646 O14258 affinity chromatography technology 19720063 physical association X 2 O74825 O94646 two hybrid 19720063 direct interaction X 2 O74825 O94646 pull down 19720063 direct interaction X 2 Q10317 O94646 biochemical 18310102 association X 2 Q09696 O94646 biochemical 18310102 association X 2 P87306 O94646 biochemical 18310102 association X 2 O60104 O94646 affinity chromatography technology 15182371 physical association X 2 O94646 pull down 23123849 physical association C 6 O94646 ion exchange chromatography 23123849 physical association C 6 O94646 x-ray crystallography 23123849 physical association C 6 O94646 molecular sieving 23123849 physical association C 6 O94646 pull down 23123849 physical association C 7 O94646 ion exchange chromatography 23123849 physical association C 7 O94646 molecular sieving 23123849 physical association C 7 Q9US45 O94646 pull down 23123849 physical association X 2 Q9US45 O94646 pull down 23123849 physical association X 2 O94646 chromatography technology 11572939 physical association C 22 O94646 O14258 pull down 19720063 direct interaction X 2 O74825 O94646 two hybrid 19720063 physical association X 2 O74825 O94646 two hybrid 19720063 physical association X 2 O74825 O94646 pull down 19720063 direct interaction X 2 O94646 chromatography technology 11572939 physical association C 13

PPI - HINT Gene A Gene B PMID Method Quality MED18 MED8 18381891,18310102,18381891 0096,0401,0114 LC RPB4 MED8 19720063,19720063 0018,0096 LC MED8 MED17 18310102 0401 LC MED8 MED10 11572939 0091 LC MED8 MED1 18310102 0401 LC MED8 MED20 18310102 0401 LC MED8 MED27 18310102 0401 LC MED18 MED8 18381891,18310102,18381891 0096,0401,0114 LC ACE2 MED8 19720063,19720063 0004,0096 LC MED7 MED8 15182371 0004 LC RPB4 MED8 19720063,19720063 0018,0096 LC MED8 MED17 18310102 0401 LC MED8 MED1 18310102 0401 LC MED8 MED20 18310102 0401 LC MED8 MED27 18310102 0401 LC MED8 SRB9 12738880 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O94646 O60104 MED8 MED7 0.21 15182371 Q9HE02 O94646 SRB9 MED8 0.21 12738880 O94646 O74825 MED8 RPB4 0.832 19720063 P87306 O94646 MED17 MED8 0.21 18310102 Q09696 O94646 MED1 MED8 0.21 18310102 Q10317 O94646 MED20 MED8 0.21 18310102 Q10477 O94646 MED27 MED8 0.21 18310102 O94646 O14198 MED8 MED18 0.623 18310102,18381891 O94646 O14258 MED8 ACE2 0.61 19720063