PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O14170 Q9Y709 affinity chromatography technology 12167173 physical association X 2 O14170 Q9Y709 two hybrid 17016471 direct interaction X 2 Q9Y709 Q9Y709 two hybrid 11820777 direct interaction X 2 Q9Y709 O94334 affinity chromatography technology 15147268 physical association X 2 Q9Y709 P36613 two hybrid 15555586 direct interaction X 2 Q9Y709 P36613 affinity chromatography technology 15555586 physical association X 2 Q9Y709 O60101 two hybrid 17016471 direct interaction X 2 Q9Y709 O13960 two hybrid 17016471 direct interaction X 2 Q9Y709 Q10207 two hybrid 17016471 direct interaction X 2 Q9Y709 P15258 two hybrid 17016471 direct interaction X 2 Q9Y709 O94334 affinity chromatography technology 19748355 physical association X 2 O13746 Q9Y709 two hybrid 17016471 direct interaction X 2 O74531 Q9Y709 affinity chromatography technology 15147268 physical association X 2 O74531 Q9Y709 two hybrid 17016471 direct interaction X 2 O74531 Q9Y709 affinity chromatography technology 19748355 physical association X 2 Q10223 Q9Y709 affinity chromatography technology 17016471 physical association X 2 Q10223 Q9Y709 affinity chromatography technology 17016471 physical association X 2 Q10223 Q9Y709 two hybrid 17016471 direct interaction X 2 Q10223 Q9Y709 two hybrid 17016471 direct interaction X 2 O00091 Q9Y709 two hybrid 17016471 direct interaction X 2 Q9USU3 Q9Y709 pull down 25165823 direct interaction X 2 Q9USU3 Q9Y709 affinity chromatography technology 15147268 physical association X 2 Q9USU3 Q9Y709 affinity chromatography technology 18312697 physical association X 2 Q9P7W4 Q9Y709 two hybrid 11820777 direct interaction X 2 Q9P7W4 Q9Y709 affinity chromatography technology 11820777 physical association X 2 Q9P7W4 Q9Y709 affinity chromatography technology 15147268 physical association X 2 Q9P7W4 Q9Y709 two hybrid 17016471 direct interaction X 2 Q9P7W4 Q9Y709 affinity chromatography technology 19748355 physical association X 2 Q9Y709 O13790 affinity chromatography technology 23535663 physical association X 2 Q9Y709 O13790 affinity chromatography technology 11337588 physical association X 2 Q9Y709 P87053 two hybrid 11820777 direct interaction X 2 Q9Y709 O74991 affinity chromatography technology 11809834 physical association X 2 Q9Y709 O13790 affinity chromatography technology 15147268 physical association X 2 Q9Y709 P87060 affinity chromatography technology 15147268 physical association X 2 Q9Y709 P87053 affinity chromatography technology 15147268 physical association X 2 Q9Y709 O74991 affinity chromatography technology 15147268 physical association X 2 Q9Y709 O74381 affinity chromatography technology 15147268 physical association X 2 Q9Y709 O60053 affinity chromatography technology 15147268 physical association X 2 Q9Y709 O13959 affinity chromatography technology 12167173 physical association X 2 Q9Y709 P87060 affinity chromatography technology 12167173 physical association X 2 Q9Y709 O13790 affinity chromatography technology 12167173 physical association X 2 Q9Y709 O94684 two hybrid 15555586 direct interaction X 2 Q9Y709 O94684 affinity chromatography technology 15555586 physical association X 2 Q9Y709 O13790 affinity chromatography technology 15555586 physical association X 2 Q9Y709 O94684 two hybrid 17016471 direct interaction X 2 Q9Y709 Q9P7D7 two hybrid 17016471 direct interaction X 2 Q9Y709 P30666 two hybrid 17016471 direct interaction X 2 Q9Y709 Q01663 two hybrid 17016471 direct interaction X 2 Q9Y709 O74991 two hybrid 16997270 direct interaction X 2 Q9Y709 Q9Y817 affinity chromatography technology 18441123 physical association X 2 Q9Y709 P87053 affinity chromatography technology 19748355 physical association X 2 Q9Y709 O74991 affinity chromatography technology 19748355 physical association X 2 Q9Y709 O74381 affinity chromatography technology 19748355 physical association X 2 Q9Y709 O60053 affinity chromatography technology 19748355 physical association X 2 Q9Y709 O74991 affinity chromatography technology 20230746 physical association X 2 O74854 Q9Y709 two hybrid 12511573 direct interaction X 2 O74854 Q9Y709 two hybrid 17016471 direct interaction X 2 Q9URY2 Q9Y709 two hybrid 17016471 direct interaction X 2 O13795 Q9Y709 affinity chromatography technology 15147268 physical association X 2 O13795 Q9Y709 affinity chromatography technology 19748355 physical association X 2 Q9USP0 Q9Y709 two hybrid 17016471 direct interaction X 2 Q9UT25 Q9Y709 two hybrid 17016471 direct interaction X 2 O14235 Q9Y709 affinity chromatography technology 15147268 physical association X 2 Q9Y709 anti bait coimmunoprecipitation 12167173 association C 3 O14170 Q9Y709 anti bait coimmunoprecipitation 15147268 physical association X 2 O14170 Q9Y709 two hybrid 17016471 physical association X 2 Q9Y709 O59704 two hybrid 11820777 physical association X 2 Q9Y709 O74783 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 O94334 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 P36613 two hybrid 15555586 physical association X 2 Q9Y709 P36613 two hybrid 15555586 physical association X 2 Q9Y709 P36613 anti tag coimmunoprecipitation 15555586 physical association X 2 Q9Y709 P15258 two hybrid 17016471 physical association X 2 Q9Y709 Q10207 two hybrid 17016471 physical association X 2 Q9Y709 O60101 two hybrid 17016471 physical association X 2 Q9Y709 O13960 two hybrid 17016471 physical association X 2 Q9Y709 P36596 anti tag coimmunoprecipitation 17016471 physical association X 2 O13746 Q9Y709 two hybrid 17016471 physical association X 2 Q9Y7Z7 Q9Y709 two hybrid 11820777 physical association X 2 Q9Y7Z7 Q9Y709 two hybrid 17016471 physical association X 2 O74531 Q9Y709 anti bait coimmunoprecipitation 15147268 physical association X 2 O74531 Q9Y709 two hybrid 17016471 physical association X 2 Q10223 Q9Y709 two hybrid 17016471 physical association X 2 Q10223 Q9Y709 two hybrid 17016471 physical association X 2 Q10223 Q9Y709 anti tag coimmunoprecipitation 17016471 physical association X 2 Q10223 Q9Y709 anti tag coimmunoprecipitation 17016471 physical association X 2 Q10223 Q9Y709 two hybrid 17016471 physical association X 2 O00091 Q9Y709 two hybrid 17016471 physical association X 2 O59671 Q9Y709 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9USU3 Q9Y709 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 anti bait coimmunoprecipitation 12167173 association C 4 Q9Y709 anti bait coimmunoprecipitation 12167173 association C 4 Q9Y709 anti bait coimmunoprecipitation 12167173 association C 4 Q9Y709 anti bait coimmunoprecipitation 12167173 association C 5 Q9Y709 anti bait coimmunoprecipitation 12167173 association C 5 Q9Y709 anti bait coimmunoprecipitation 12167173 association C 5 Q9Y709 anti bait coimmunoprecipitation 12167173 association C 5 Q9P7W4 Q9Y709 two hybrid 11820777 physical association X 2 Q9P7W4 Q9Y709 two hybrid 11820777 physical association X 2 Q9P7W4 Q9Y709 anti tag coimmunoprecipitation 11820777 physical association X 2 Q9P7W4 Q9Y709 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9P7W4 Q9Y709 two hybrid 17016471 physical association X 2 Q9Y709 P87053 two hybrid 11820777 physical association X 2 Q9Y709 O13959 anti bait coimmunoprecipitation 12167173 physical association X 2 Q9Y709 O13790 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 O74991 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 O74381 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 Q09855 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 O60053 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 P87060 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 P87053 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9Y709 O94684 anti tag coimmunoprecipitation 15555586 physical association X 2 Q9Y709 O94684 two hybrid 15555586 physical association X 2 Q9Y709 O74991 two hybrid 16997270 physical association X 2 Q9Y709 O74991 anti tag coimmunoprecipitation 16997270 physical association X 2 Q9Y709 P30666 two hybrid 17016471 physical association X 2 Q9Y709 Q9P7D7 two hybrid 17016471 physical association X 2 Q9Y709 O94684 two hybrid 17016471 physical association X 2 Q9Y709 Q01663 two hybrid 17016471 physical association X 2 O74854 Q9Y709 two hybrid 12511573 physical association X 2 O74854 Q9Y709 pull down 12511573 physical association X 2 O74854 Q9Y709 anti bait coimmunoprecipitation 15147268 physical association X 2 O74854 Q9Y709 two hybrid 17016471 physical association X 2 Q9URY2 Q9Y709 two hybrid 17016471 physical association X 2 O13795 Q9Y709 anti bait coimmunoprecipitation 15147268 physical association X 2 Q9USP0 Q9Y709 two hybrid 17016471 physical association X 2 Q9UT25 Q9Y709 two hybrid 17016471 physical association X 2 Q9P7Y9 Q9Y709 two hybrid 11820777 physical association X 2 O14235 Q9Y709 two hybrid 11820777 physical association X 2 O14235 Q9Y709 anti bait coimmunoprecipitation 15147268 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality ZWF1 SKP1 17016471 0018 LC O13746 SKP1 17016471 0018 LC ECM33 SKP1 17016471 0018 LC POP2 SKP1 17016471 0018 LC POF5 SKP1 11820777 0018 LC IKI3 SKP1 11820777 0018 LC PGK1 SKP1 17016471 0018 LC POF7 SKP1 17016471 0018 LC POF6 SKP1 12511573,12511573,17016471 0096,0018,0018 LC POF3 SKP1 16997270,16997270 0007,0018 LC PMH1 SKP1 15555586,15555586,15555586,17016471 0018,0007,0004,0018 LC RAL2 SKP1 17016471 0018 LC MCM3 SKP1 17016471 0018 LC MCS2 SKP1 15555586,15555586,15555586 0018,0007,0004 LC HAP5 SKP1 26771498 0018 HT POF1 SKP1 11820777,26771498 0018,0018 LC,HT PAP1 SKP1 17016471 0018 LC Q10207 SKP1 17016471 0018 LC POF14 SKP1 17016471,17016471,17016471 0004,0007,0018 LC LCF2 SKP1 17016471 0018 LC POF10 SKP1 11820777,11820777,17016471,11820777 0018,0007,0018,0004 LC SIN1 SKP1 11820777 0018 LC ALP7 SKP1 17016471 0018 LC TIF221 SKP1 17016471 0018 LC Q9UT25 SKP1 17016471 0018 LC SKP1 SKP1 11820777 0018 LC SKP1 MRP15 11820777,17016471 0018,0018 LC CUL1 SKP1 15147268,15147268,11337588,15555586,12167173,23535663,12167173 0006,0004,0004,0004,0004,0004,0006 LC POF8 SKP1 19748355,15147268,15147268 0004,0006,0004 LC PIP1 SKP1 12167173,12167173 0006,0004 LC POP2 SKP1 15147268,12167173,12167173 0006,0006,0004 LC POF5 SKP1 15147268,15147268 0006,0004 LC POF4 SKP1 15147268 0006 LC POF12 SKP1 19748355,15147268,15147268 0004,0006,0004 LC POF9 SKP1 19748355,15147268,15147268 0004,0006,0004 LC POF7 SKP1 19748355,15147268,15147268 0004,0004,0006 LC POF2 SKP1 15147268 0006 LC POF6 SKP1 12511573,15147268,12511573 0096,0006,0018 LC POF3 SKP1 20230746,15147268,16997270,16997270,15147268,19748355,11809834 0004,0006,0007,0018,0004,0004,0004 LC POF13 SKP1 19748355,15147268,15147268 0004,0006,0004 LC PMH1 SKP1 15555586,15555586,15555586 0018,0007,0004 LC ERG9 SKP1 17016471 0007 LC MCS2 SKP1 15555586,15555586,15555586 0018,0007,0004 LC POF1 SKP1 19748355,15147268,15147268 0004,0006,0004 LC POP1 SKP1 15147268,12167173,12167173,15147268 0006,0006,0004,0004 LC POF11 SKP1 15147268 0006 LC POF14 SKP1 17016471,17016471,17016471 0004,0007,0018 LC POF10 SKP1 11820777,15147268,11820777,19748355,15147268,11820777 0018,0006,0007,0004,0004,0004 LC FBH1 SKP1 18312697,15147268,15147268,25165823 0004,0006,0004,0096 LC SKP1 RAV1 18441123 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y709 Q09855 SKP1 POF11 0.21 15147268 Q9Y709 O59671 SKP1 POF4 0.21 15147268 Q9Y709 O60053 SKP1 POF12 0.507 15147268,19748355 Q9Y709 O74381 SKP1 POF9 0.507 15147268,19748355 Q9Y709 O59704 SKP1 IKI3 0.309 11820777 Q9Y709 O74783 SKP1 POF2 0.21 15147268 Q9Y709 P36596 SKP1 ERG9 0.126 17016471 Q9Y709 P87060 SKP1 POP1 0.61 12167173,15147268 Q9Y709 Q9Y709 SKP1 SKP1 0.332 11820777 Q9Y7Z7 Q9Y709 MRPL15 SKP1 0.436 17016471,11820777 Q9Y817 Q9Y709 RAV1 SKP1 0.21 18441123 Q9Y709 O94334 SKP1 POF13 0.507 15147268,19748355 Q9Y709 Q9UT25 SKP1 Q9UT25 0.332 17016471 Q9Y709 O60101 SKP1 PGK1 0.332 17016471 Q9Y709 Q9USU3 SKP1 FBH1 0.659 15147268,18312697,25165823 Q9Y709 Q10207 SKP1 Q10207 0.332 17016471 Q9Y709 P30666 SKP1 MCM3 0.332 17016471 Q9Y709 O74991 SKP1 POF3 0.884 16997270,19748355,11809834,15147268,20230746 Q9Y709 O13960 SKP1 ECM33 0.332 17016471 Q9Y709 O13790 SKP1 CUL1 0.808 15147268,23535663,11337588,12167173,15555586 Q9Y709 P87053 SKP1 POF1 0.808 15147268,11820777,19748355,26771498 Q9Y709 O14170 SKP1 POP2 0.671 17016471,15147268,12167173 Q9Y709 O74531 SKP1 POF7 0.671 17016471,15147268,19748355 Q9Y709 O13959 SKP1 PIP1 0.507 12167173 Q9Y709 O94684 SKP1 PMH1 0.801 17016471,15555586 Q9Y709 Q9P7W4 SKP1 POF10 0.902 15147268,11820777,19748355,17016471 Q9Y709 Q10223 SKP1 POF14 0.74 17016471 Q9Y709 P36613 SKP1 MCS2 0.702 15555586 Q9Y709 O74854 SKP1 POF6 0.801 17016471,15147268,12511573 Q9Y709 Q9P7D7 SKP1 LCF2 0.332 17016471 Q9Y709 Q9P7Y9 SKP1 SIN1 0.309 11820777 Q9Y709 Q9URY2 SKP1 ALP7 0.332 17016471 Q9Y709 Q9USP0 SKP1 TIF221 0.332 17016471 Q9Y709 P79007 SKP1 HAP5 0.183 26771498 Q9Y709 Q01663 SKP1 PAP1 0.332 17016471 Q9Y709 O00091 SKP1 ZWF1 0.332 17016471 Q9Y709 P15258 SKP1 RAL2 0.332 17016471 Q9Y709 O13746 SKP1 O13746 0.332 17016471 Q9Y709 O13795 SKP1 POF8 0.507 15147268,19748355 Q9Y709 O14235 SKP1 POF5 0.569 15147268,11820777