PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O94359 O43071 affinity chromatography technology 21386897 physical association X 2 P87126 O43071 affinity chromatography technology 21386897 physical association X 2 P87126 O43071 affinity chromatography technology 21386897 physical association X 2 Q7LL14 O43071 affinity chromatography technology 21386897 physical association X 2 O14011 O43071 affinity chromatography technology 21386897 physical association X 2 O14011 O43071 affinity chromatography technology 21386897 physical association X 2 O14011 O43071 affinity chromatography technology 21386897 physical association X 2 O14011 O43071 affinity chromatography technology 21386897 physical association X 2 O14011 O43071 two hybrid 21386897 direct interaction X 2 O14011 O43071 pull down 21386897 direct interaction X 2 Q9UT73 O43071 affinity chromatography technology 21386897 physical association X 2 Q06975 O43071 affinity chromatography technology 21386897 physical association X 2 Q10752 O43071 affinity chromatography technology 21386897 physical association X 2 O59816 O43071 affinity chromatography technology 21386897 physical association X 2 Q10253 O43071 affinity chromatography technology 21386897 physical association X 2 O74370 O43071 affinity chromatography technology 21386897 physical association X 2 O13713 O43071 affinity chromatography technology 24081329 physical association X 2 P36616 O43071 affinity chromatography technology 21386897 physical association X 2 Q9C1X0 O43071 affinity chromatography technology 21386897 physical association X 2 O74772 O43071 affinity chromatography technology 24874881 physical association X 2 O74772 O43071 affinity chromatography technology 21386897 physical association X 2 O14097 O43071 affinity chromatography technology 21386897 physical association X 2 O43071 P39964 biochemical 24014766 association X 2 O43071 O94316 biochemical 24014766 association X 2 O43071 O94316 affinity chromatography technology 24442611 physical association X 2 O43071 O94316 affinity chromatography technology 24442611 physical association X 2 O43071 P39964 affinity chromatography technology 15755920 physical association X 2 O43071 Q9UU80 affinity chromatography technology 21386897 physical association X 2 O43071 Q9UUC6 affinity chromatography technology 21386897 physical association X 2 O43071 P87051 affinity chromatography technology 21386897 physical association X 2 O43071 O13615 affinity chromatography technology 21386897 physical association X 2 O43071 O94316 affinity chromatography technology 21386897 physical association X 2 O43071 P39964 affinity chromatography technology 21386897 physical association X 2 O43071 O59733 affinity chromatography technology 21386897 physical association X 2 O43071 Q10414 affinity chromatography technology 21386897 physical association X 2 O43071 Q9HE06 affinity chromatography technology 21386897 physical association X 2 Q9UTT2 O43071 affinity chromatography technology 21386897 physical association X 2 O74517 O43071 affinity chromatography technology 21386897 physical association X 2 O59734 O43071 affinity chromatography technology 21386897 physical association X 2 Q9P774 O43071 affinity chromatography technology 21386897 physical association X 2 O13826 O43071 affinity chromatography technology 21386897 physical association X 2 O74555 O43071 affinity chromatography technology 21386897 physical association X 2 Q9HE07 O43071 affinity chromatography technology 21386897 physical association X 2 O42661 O43071 affinity chromatography technology 21386897 physical association X 2 P36629 O43071 affinity chromatography technology 21386897 physical association X 2 Q9P7X3 O43071 affinity chromatography technology 21386897 physical association X 2 O42643 O43071 affinity chromatography technology 21386897 physical association X 2 Q9P6R8 O43071 affinity chromatography technology 21386897 physical association X 2 P78794 O43071 affinity chromatography technology 21386897 physical association X 2 Q9USV3 O43071 affinity chromatography technology 21386897 physical association X 2 Q9USV3 O43071 affinity chromatography technology 21386897 physical association X 2 Q09882 O43071 affinity chromatography technology 21386897 physical association X 2 P87312 O43071 affinity chromatography technology 21386897 physical association X 2 O42945 O43071 affinity chromatography technology 21386897 physical association X 2 Q9Y805 O43071 affinity chromatography technology 21386897 physical association X 2 O14113 O43071 affinity chromatography technology 25274039 physical association X 2 O14113 O43071 affinity chromatography technology 21386897 physical association X 2 O14102 O43071 affinity chromatography technology 21386897 physical association X 2 O59793 O43071 affinity chromatography technology 21386897 physical association X 2 O94417 O43071 affinity chromatography technology 21386897 physical association X 2 O43071 O94326 affinity chromatography technology 24713849 physical association X 2 O43071 O43071 affinity chromatography technology 21386897 physical association X 2 O43071 Q9P7R9 affinity chromatography technology 21386897 physical association X 2 O43071 O94620 affinity chromatography technology 21386897 physical association X 2 O43071 Q09909 affinity chromatography technology 21386897 physical association X 2 O43071 Q10163 affinity chromatography technology 21386897 physical association X 2 Q10422 O43071 affinity chromatography technology 21386897 physical association X 2 O13845 O43071 affinity chromatography technology 21386897 physical association X 2 O43071 Q9UT24 affinity chromatography technology 21386897 physical association X 2 O43071 O59706 affinity chromatography technology 21386897 physical association X 2 O43071 O13900 affinity chromatography technology 21386897 physical association X 2 Q9UTK6 O43071 affinity chromatography technology 21386897 physical association X 2 Q9P7R6 O43071 affinity chromatography technology 21386897 physical association X 2 Q9UUI3 O43071 affinity chromatography technology 21386897 physical association X 2 Q9UTR8 O43071 affinity chromatography technology 24713849 physical association X 2 Q9USM4 O43071 affinity chromatography technology 21386897 physical association X 2 Q9P7Z6 O43071 affinity chromatography technology 21386897 physical association X 2 Q9P7C5 O43071 affinity chromatography technology 21386897 physical association X 2 Q10178 O43071 affinity chromatography technology 21386897 physical association X 2 O74966 O43071 affinity chromatography technology 21386897 physical association X 2 O13799 O43071 affinity chromatography technology 24713849 physical association X 2 O94508 O43071 affinity chromatography technology 21386897 physical association X 2 O14161 O43071 affinity chromatography technology 21386897 physical association X 2 P40235 O43071 affinity chromatography technology 24055157 physical association X 2 Q09685 O43071 affinity chromatography technology 21386897 physical association X 2 Q09685 O43071 affinity chromatography technology 21386897 physical association X 2 Q9P7L8 O43071 affinity chromatography technology 21386897 physical association X 2 O74970 O43071 affinity chromatography technology 21386897 physical association X 2 Q9USZ3 O43071 affinity chromatography technology 21386897 physical association X 2 O59800 O43071 affinity chromatography technology 21386897 physical association X 2 Q9USX8 O43071 affinity chromatography technology 24442611 physical association X 2 Q9USX8 O43071 affinity chromatography technology 24442611 physical association X 2 Q9USX8 O43071 affinity chromatography technology 21386897 physical association X 2 O14187 O43071 affinity chromatography technology 21386897 physical association X 2 Q9UTB8 O43071 affinity chromatography technology 21386897 physical association X 2 O14256 O43071 affinity chromatography technology 21386897 physical association X 2 O43071 tandem affinity purification 11884590 association C 48 O43071 tandem affinity purification 21386897 association C 33 O14011 O43071 anti tag coimmunoprecipitation 21386897 physical association X 2 O14011 O43071 anti tag coimmunoprecipitation 21386897 physical association X 2 O43071 tandem affinity purification 21386897 association C 13 O43071 anti tag coimmunoprecipitation 21386897 association C 3 O43071 tandem affinity purification 21386897 association C 47 O43071 tandem affinity purification 21386897 association C 41 O43071 anti tag coimmunoprecipitation 21386897 association C 3 O43071 anti tag coimmunoprecipitation 21386897 association C 3

PPI - HINT Gene A Gene B PMID Method Quality PRP19 PRP17 21386897,21386897,21386897,21386897,21386897 0004,0018,0007,0676,0096 LC PRP17 CWF10 24014766 0401 LC PRP17 CDC5 24014766 0401 LC PRP5 PRP17 21386897,21386897 0004,0676 LC NAB2 PRP17 24081329 0004 LC O13799 PRP17 24713849 0004 HT RFP1 PRP17 21386897 0004 LC RSD1 PRP17 21386897 0004 LC SAP114 PRP17 21386897 0004 LC PRP19 PRP17 21386897,21386897,21386897,21386897,21386897 0004,0018,0007,0676,0096 LC SMD2 PRP17 21386897 0676 LC O14097 PRP17 21386897,21386897 0004,0676 LC SAP49 PRP17 21386897,21386897 0004,0676 LC SDE2 PRP17 25274039,21386897 0004,0004 LC CWF21 PRP17 21386897,21386897 0004,0676 LC SPP42 PRP17 21386897,21386897 0004,0676 LC O14256 PRP17 21386897 0004 LC PRP22 PRP17 21386897,21386897 0004,0676 LC SMD1 PRP17 21386897,21386897 0004,0676 LC PRP43 PRP17 21386897,21386897 0004,0676 LC PRP17 PRP17 21386897 0004 LC PRP17 SAP61 21386897,21386897 0004,0676 LC PRP17 SYF2 21386897,21386897 0004,0676 LC PRP17 SMF1 21386897,21386897 0004,0676 LC PRP17 BIS1 21386897 0004 LC PRP17 CWF5 21386897,21386897 0004,0676 LC PRP17 LAT1 21386897 0004 LC PRP17 SAF4 21386897 0676 LC PRP17 CWF12 21386897,21386897 0004,0676 LC PRP17 SAF1 21386897,21386897 0004,0676 LC PRP17 BPB1 21386897 0004 LC PRP17 CWF14 21386897,21386897,24874881 0004,0676,0004 LC PRP17 SMG1 21386897,21386897 0004,0676 LC PRP17 PRP39 21386897 0004 LC PRP17 CWF10 21386897,21386897,24442611,24014766 0676,0004,0004,0401 LC PRP17 O94326 24713849 0004 HT PRP17 O94359 21386897 0004 LC PRP17 CWF26 21386897,21386897 0004,0676 LC PRP17 CWF11 21386897,21386897 0004,0676 LC PRP17 CWF17 21386897,21386897 0004,0676 LC PRP17 PPI1 21386897 0004 LC PRP17 DSK1 21386897 0004 LC PRP17 PRP2 21386897 0004 LC PRP17 CDC5 15755920,21386897,21386897,24014766,11884590 0004,0004,0676,0401,0676 LC PRP17 CWF15 21386897,21386897 0004,0676 LC PRP17 CWF2 21386897,21386897 0004,0676 LC PRP17 CWF4 21386897,21386897 0004,0676 LC PRP17 GAR1 21386897 0004 LC PRP17 DRE4 21386897 0004 LC PRP17 PRP45 21386897,21386897 0004,0676 LC PRP17 CWF19 21386897,21386897 0004,0676 LC PRP17 SMB1 21386897,21386897 0004,0676 LC PRP17 PRP10 21386897 0004 LC PRP17 MUG64 21386897 0004 LC PRP17 MUG161 21386897 0004 LC PRP17 Q10422 21386897 0004 LC PRP17 CDC28 21386897 0004 LC PRP17 MSL1 21386897 0004 LC PRP17 Q9C1X0 21386897 0004 LC PRP17 Q9HE06 21386897 0004 LC PRP17 Q9HE07 21386897 0004 LC PRP17 CWF24 21386897 0004 LC PRP17 CWF22 21386897 0676 LC PRP17 PRP16 21386897,21386897 0004,0676 LC PRP17 CWF16 21386897,21386897 0004,0676 LC PRP17 SAP62 21386897 0004 LC PRP17 Q9P7R6 21386897 0004 LC PRP17 CWF3 21386897,21386897 0004,0676 LC PRP17 FRG1 21386897 0004 LC PRP17 Q9P7Z6 21386897 0004 LC PRP17 USP106 21386897 0004 LC PRP17 CWF7 21386897,21386897,21386897 0004,0007,0676 LC PRP17 LEA1 21386897,21386897,24442611 0676,0004,0004 LC PRP17 SME1 21386897 0004 LC PRP17 BRR2 21386897,21386897 0004,0676 LC PRP17 Q9UT73 21386897 0004 LC PRP17 INI1 21386897 0004 LC PRP17 Q9UTK6 21386897 0004 LC PRP17 RED1 24713849 0004 HT PRP17 PRP12 21386897 0004 LC PRP17 CWF18 21386897,21386897 0004,0676 LC PRP17 SMD3 21386897,21386897 0004,0676 LC PRP17 SAP145 21386897 0004 LC PRP17 CWF25 21386897,21386897 0004,0676 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q09685 O43071 DRE4 PRP17 0.126 21386897 O43071 O14036 PRP17 SMD2 0.126 21386897 O43071 O13845 PRP17 RSD1 0.126 21386897 O43071 O13900 PRP17 SAP114 0.126 21386897 O43071 O13826 PRP17 RFP1 0.126 21386897 Q9HE06 O43071 Q9HE06 PRP17 0.126 21386897 O74772 O43071 CWF14 PRP17 0.332 21386897,24874881 O43071 O14256 PRP17 O14256 0.126 21386897 O94359 O43071 O94359 PRP17 0.126 21386897 O43071 O43071 PRP17 PRP17 0.155 21386897 O60141 O43071 SAF4 PRP17 0.126 21386897 O59816 O43071 LAT1 PRP17 0.126 21386897 O59793 O43071 BIS1 PRP17 0.126 21386897 O74555 O43071 BPB1 PRP17 0.126 21386897 O74970 O43071 PRP39 PRP17 0.126 21386897 P36616 O43071 DSK1 PRP17 0.126 21386897 Q06975 O43071 GAR1 PRP17 0.126 21386897 P36629 O43071 PRP2 PRP17 0.126 21386897 Q9C1X0 O43071 Q9C1X0 PRP17 0.126 21386897 P87051 O43071 PPI1 PRP17 0.126 21386897 Q7LL14 O43071 MSL1 PRP17 0.126 21386897 Q10752 O43071 CDC28 PRP17 0.126 21386897 Q10178 O43071 PRP10 PRP17 0.126 21386897 Q10422 O43071 Q10422 PRP17 0.126 21386897 Q10414 O43071 MUG161 PRP17 0.126 21386897 Q10253 O43071 MUG64 PRP17 0.126 21386897 Q9P7L8 O43071 SAP62 PRP17 0.126 21386897 Q9HE07 O43071 Q9HE07 PRP17 0.126 21386897 Q9P6R9 O43071 CWF22 PRP17 0.126 21386897 Q9P6R8 O43071 CWF24 PRP17 0.126 21386897 Q9USZ3 O43071 SME1 PRP17 0.126 21386897 Q9U523 O43071 ALPHA-CATENIN-RELATED PRP17 0.126 21386897 Q9P7Z6 O43071 Q9P7Z6 PRP17 0.126 21386897 Q9P7X3 O43071 FRG1 PRP17 0.126 21386897 Q9P7R6 O43071 Q9P7R6 PRP17 0.126 21386897 Q9USM4 O43071 USP106 PRP17 0.126 21386897 Q9UTB8 O43071 INI1 PRP17 0.126 21386897 Q9UT73 O43071 Q9UT73 PRP17 0.126 21386897 Q9UUI3 O43071 SAP145 PRP17 0.126 21386897 Q9UTT2 O43071 PRP12 PRP17 0.126 21386897 Q9UTK6 O43071 Q9UTK6 PRP17 0.126 21386897 O94326 O43071 O94326 PRP17 0.126 24713849 Q9USV3 O43071 CWF7 PRP17 0.416 21386897 P87126 O43071 CWF2 PRP17 0.416 21386897 O43071 O14102 PRP17 SAP49 0.236 21386897 O43071 O13615 PRP17 PRP5 0.236 21386897 O94417 O43071 CWF26 PRP17 0.236 21386897 O43071 O42945 PRP17 PRP43 0.236 21386897 O43071 O42661 PRP17 SMD1 0.236 21386897 O74517 O43071 SAF1 PRP17 0.236 21386897 O43071 O42643 PRP17 PRP22 0.236 21386897 O43071 O14187 PRP17 SPP42 0.236 21386897 O43071 O14161 PRP17 CWF21 0.236 21386897 O74370 O43071 CWF12 PRP17 0.236 21386897 O59734 O43071 SMF1 PRP17 0.236 21386897 O59733 O43071 SYF2 PRP17 0.236 21386897 O59706 O43071 SAP61 PRP17 0.236 21386897 O59800 O43071 CWF5 PRP17 0.236 21386897 O74966 O43071 SMG1 PRP17 0.236 21386897 O94316 O43071 CWF10 PRP17 0.416 21386897,24014766,24442611 P78794 O43071 CWF15 PRP17 0.236 21386897 O94620 O43071 CWF17 PRP17 0.236 21386897 O94508 O43071 CWF11 PRP17 0.236 21386897 P39964 O43071 CDC5 PRP17 0.49 21386897,24014766,11884590,15755920 P87312 O43071 CWF4 PRP17 0.236 21386897 Q09882 O43071 PRP45 PRP17 0.236 21386897 Q09909 O43071 CWF19 PRP17 0.236 21386897 Q10163 O43071 SMB1 PRP17 0.236 21386897 Q9UT24 O43071 BRR2 PRP17 0.236 21386897 Q9P7C5 O43071 CWF16 PRP17 0.236 21386897 Q9P774 O43071 PRP16 PRP17 0.236 21386897 Q9P7R9 O43071 CWF3 PRP17 0.236 21386897 Q9UUC6 O43071 SMD3 PRP17 0.236 21386897 Q9UU80 O43071 CWF18 PRP17 0.236 21386897 Q9Y805 O43071 CWF25 PRP17 0.236 21386897 O43071 O14011 PRP17 CWF8 0.702 21386897 Q9USX8 O43071 LEA1 PRP17 0.332 21386897,24442611 Q9UTR8 O43071 RED1 PRP17 0.126 24713849 O43071 O13713 PRP17 NAB2 0.21 24081329 O43071 O13799 PRP17 O13799 0.126 24713849 O43071 O14097 PRP17 O14097 0.236 21386897 O43071 O14113 PRP17 SDE2 0.309 21386897,25274039