PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q53EK2 Q6BDR8 affinity chromatography technology 16478984 physical association X 2 Q53EK2 O94668 affinity chromatography technology 16478984 physical association X 2 Q53EK2 Q9Y7L8 two hybrid 15331764 direct interaction X 2 Q53EK2 O60101 two hybrid 15331764 direct interaction X 2 Q53EK2 O74978 two hybrid 15331764 direct interaction X 2 Q53EK2 O14253 two hybrid 15331764 direct interaction X 2 Q53EK2 O94668 affinity chromatography technology 16478984 physical association X 2 Q53EK2 Q9Y7U4 two hybrid 21364888 direct interaction X 2 Q53EK2 P53692 affinity chromatography technology 14701739 physical association X 2 Q53EK2 O13710 affinity chromatography technology 16478984 physical association X 2 Q53EK2 O13688 affinity chromatography technology 16478984 physical association X 2 Q53EK2 O13710 pull down 16478984 direct interaction X 2 Q53EK2 O13710 affinity chromatography technology 12966087 physical association X 2 Q53EK2 O13710 affinity chromatography technology 12966087 physical association X 2 Q53EK2 P53692 affinity chromatography technology 15601840 physical association X 2 Q53EK2 Q9Y7U4 pull down 15601840 direct interaction X 2 Q53EK2 O13710 affinity chromatography technology 15331764 physical association X 2 Q53EK2 Q9Y7U4 affinity chromatography technology 15331764 physical association X 2 Q53EK2 Q9Y7U4 two hybrid 15331764 direct interaction X 2 Q53EK2 O13688 affinity chromatography technology 16478984 physical association X 2 Q53EK2 anti tag coimmunoprecipitation 15601840 association C 6 Q53EK2 anti tag coimmunoprecipitation 15601840 association C 6 Q53EK2 pull down 15601840 association C 3 Q53EK2 three hybrid 21364888 physical association C 3 Q53EK2 Q6BDR8 pull down 15331764 physical association X 2 Q53EK2 Q6BDR8 pull down 15601840 physical association X 2 Q53EK2 O94668 pull down 16478984 physical association X 2 Q53EK2 Q6BDR8 pull down 21364888 physical association X 2 Q53EK2 tandem affinity purification 16478984 association C 8 Q53EK2 tandem affinity purification 16478984 association C 8 Q53EK2 O13710 molecular sieving 12966087 physical association X 2 Q53EK2 O13710 tandem affinity purification 12966087 physical association X 2 Q53EK2 O13710 pull down 12966087 physical association X 2 Q53EK2 P53692 anti tag coimmunoprecipitation 14701739 physical association X 2 Q53EK2 Q9Y7U4 pull down 15331764 physical association X 2 Q53EK2 Q9Y7U4 two hybrid 15331764 physical association X 2 Q53EK2 O13710 tandem affinity purification 15331764 physical association X 2 Q53EK2 Q9Y7U4 pull down 15601840 physical association X 2 Q53EK2 Q9Y7U4 pull down 15601840 physical association X 2 Q53EK2 Q9Y7U4 pull down 15601840 physical association X 2 Q53EK2 Q9Y7U4 pull down 15601840 physical association X 2 Q53EK2 P53692 pull down 16478984 physical association X 2 Q53EK2 O13710 pull down 16478984 physical association X 2 Q53EK2 O13710 anti tag coimmunoprecipitation 16478984 physical association X 2 Q53EK2 O13688 pull down 16478984 physical association X 2 Q53EK2 Q9Y7U4 two hybrid 21364888 physical association X 2 Q53EK2 Q9Y7U4 pull down 21364888 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality SMC5 NSE1 12966087,12966087,12966087,12966087 0676,0071,0004,0096 LC CBC1 NSE1 15331764 0018 LC PGK1 NSE1 15331764 0018 LC O74978 NSE1 15331764 0018 LC NSE1 RPS001 15331764 0018 LC NSE1 NSE3 21364888,15331764,21364888,15331764,21364888,15331764 0588,0018,0096,0096,0018,0004 LC NSE6 NSE1 16478984,16478984,16478984 0096,0676,0004 LC SMC5 NSE1 16478984,12966087,15331764,16478984,12966087,16478984,12966087,15331764,12966087 0096,0676,0676,0007,0071,0004,0004,0004,0096 LC NSE5 NSE1 16478984,16478984 0096,0004 LC SMC6 NSE1 16478984,15601840,14701739,15601840,14701739 0096,0007,0007,0004,0004 LC NSE1 NSE4 15601840,16478984,21364888,16478984,15331764 0096,0676,0096,0004,0096 LC NSE1 NSE3 21364888,15331764,21364888,15601840,15331764,21364888,15331764 0588,0018,0096,0096,0096,0018,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q53EK2 O94668 NSE1 NSE5 0.21 16478984 Q9Y7U4 Q53EK2 NSE3 NSE1 0.837 15601840,21364888,15331764 Q53EK2 O13710 NSE1 SMC5 0.659 16478984,12966087,15331764 Q53EK2 O13688 NSE1 NSE6 0.21 16478984 Q53EK2 O14253 NSE1 CBC1 0.309 15331764 Q53EK2 O60101 NSE1 PGK1 0.309 15331764 Q53EK2 O74978 NSE1 O74978 0.309 15331764 Q53EK2 P53692 NSE1 SMC6 0.507 15601840,14701739 Q6BDR8 Q53EK2 NSE4 NSE1 0.507 16478984,15601840 Q9Y7L8 Q53EK2 RPS0A NSE1 0.309 15331764