PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O74910 Q10426 - 16040243 - X 2 Q9URT4 O74910 affinity chromatography technology 23267073 physical association X 2 O74910 O74560 affinity chromatography technology 20211136 physical association X 2 O74910 Q10426 affinity chromatography technology 20211136 physical association X 2 O74910 Q10426 pull down 24449894 direct interaction X 2 O74910 O74560 pull down 24449894 direct interaction X 2 O74910 Q10426 pull down 24449894 direct interaction X 2 O74910 O74560 pull down 24449894 direct interaction X 2 O74910 O74560 imaging technique 16040243 colocalization X 2 O74910 Q10426 two hybrid 16040243 direct interaction X 2 O74910 Q10426 affinity chromatography technology 16024659 physical association X 2 O74910 O74560 affinity chromatography technology 17114925 physical association X 2 O74910 Q10426 affinity chromatography technology 17114925 physical association X 2 O74910 Q10426 affinity chromatography technology 22319459 physical association X 2 O74910 Q10426 two hybrid 22319459 direct interaction X 2 O74910 O60016 affinity chromatography technology 22319459 physical association X 2 O74910 O74560 affinity chromatography technology 22319459 physical association X 2 Q9UTK4 O74910 two hybrid 16157682 direct interaction X 2 O94276 O74910 affinity chromatography technology 20211136 physical association X 2 O94276 O74910 affinity chromatography technology 20211136 physical association X 2 O94276 O74910 affinity chromatography technology 23613586 physical association X 2 O74910 Q9UTR8 affinity chromatography technology 24713849 physical association X 2 O74910 O94326 affinity chromatography technology 24713849 physical association X 2 O74910 Q9UTR8 affinity chromatography technology 22144463 physical association X 2 P40381 O74910 imaging technique 16040243 colocalization X 2 O74910 pull down 20211136 physical association C 11 O74910 tandem affinity purification 16024659 association C 7 Q9HDV4 O74910 anti tag coimmunoprecipitation 18957202 physical association X 2 O74910 Q10426 two hybrid 16040243 physical association X 2 O74910 Q10426 anti tag coimmunoprecipitation 20211136 physical association X 2 O74910 O74560 anti tag coimmunoprecipitation 20211136 physical association X 2 Q9UTK4 O74910 two hybrid 16157682 physical association X 2 O94276 O74910 anti tag coimmunoprecipitation 20211136 physical association X 2 O74910 tandem affinity purification 18957202 association C 3

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O74910 O14122 RAF1 CUL4 0.21 18957202 O74910 O60016 RAF1 CLR4 0.21 22319459 O74910 O74560 RAF1 RAF2 0.863 24449894,16040243,20211136,17114925,22319459 O94276 O74910 O94276 RAF1 0.61 23613586,20211136 Q10426 O74910 RIK1 RAF1 0.95 17114925,22319459,26771498,24449894,16040243,16024659,20211136 O94326 O74910 O94326 RAF1 0.126 24713849 Q9HDV4 O74910 LID2 RAF1 0.376 18957202 Q9URT4 O74910 AMS2 RAF1 0.21 23267073 Q9UTK4 O74910 NUP189 RAF1 0.523 16157682 Q9UTR8 O74910 RED1 RAF1 0.309 22144463,24713849 P40381 O74910 SWI6 RAF1 0.126 16040243