PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Dicer-related helicase, F15B10.2a F25H8.5k 16439208 intact exp Dicer-related helicase, F15B10.2a copb-2 16439208 intact exp Dicer-related helicase, F15B10.2a gpd-3 16439208 intact exp Dicer-related helicase, F15B10.2a mdt-1.2 16439208 intact exp Dicer-related helicase, F15B10.2a Nascent polypeptide-associated complex subunit alpha, NAC-alpha 16439208 intact exp Dicer-related helicase, F15B10.2a F31D5.3b 16439208 intact exp Dicer-related helicase, F15B10.2a F10B5.7 16439208 intact exp Dicer-related helicase, F15B10.2a enol-1 16439208 intact exp Dicer-related helicase, F15B10.2a F49E8.3b 16439208 intact exp Dicer-related helicase, F15B10.2a F54D8.6 16439208 intact exp Dicer-related helicase, F15B10.2a W09B6.3 16439208 intact exp Dicer-related helicase, F15B10.2a T10B11.3 16439208 intact exp Dicer-related helicase, F15B10.2a zbp-1 16439208 intact exp Dicer-related helicase, F15B10.2a T12D8.8 16439208 intact exp Dicer-related helicase, F15B10.2a hsp-60 16439208 intact exp Dicer-related helicase, F15B10.2a hsp-3 16439208 intact exp Dicer-related helicase, F15B10.2a Y22D7AL.10 16439208 intact exp Dicer-related helicase, F15B10.2a C26E6.7b 16439208 intact exp Dicer-related helicase, F15B10.2a W04D2.5 16439208 intact exp Dicer-related helicase, F15B10.2a Probable glutaryl-CoA dehydrogenase, mitochondrial, GCD 16439208 intact exp Dicer-related helicase, F15B10.2a F58D5.1a 16439208 intact exp Dicer-related helicase, F15B10.2a F53A2.1 16439208 intact exp Dicer-related helicase, F15B10.2a F26B1.2a 16439208 intact exp Dicer-related helicase, F15B10.2a C42D4.3 16439208 intact exp Dicer-related helicase, F15B10.2a lin-41 16439208 intact exp Dicer-related helicase, F15B10.2a C25A1.4 16439208 intact exp Dicer-related helicase, F15B10.2a cct-8 16439208 intact exp Dicer-related helicase, F15B10.2a B0001.2 16439208 intact exp Dicer-related helicase, F15B10.2a K08H10.7, RNA interference promoting factor RDE-1 16439208 intact exp Dicer-related helicase, F15B10.2a cct-2 16439208 intact exp Dicer-related helicase, F15B10.2a H05C05.1c 16439208 intact exp T06A10.3 Dicer-related helicase, F15B10.2a 16439208 intact exp Dicer-related helicase, F15B10.2a T10B5.5a 16439208 intact exp Dicer-related helicase, F15B10.2a T23G7.5a 16439208 intact exp Dicer-related helicase, F15B10.2a pyc-1 16439208 intact exp Dicer-related helicase, F15B10.2a F20D1.4 16439208 intact exp Dicer-related helicase, F15B10.2a T17H7.4d 14704431 biogrid,intact exp Dicer-related helicase, F15B10.2a dld-1 16439208 intact exp Dicer-related helicase, F15B10.2a D2005.5 16439208 intact exp Dicer-related helicase, F15B10.2a snr-2 16439208 intact exp Dicer-related helicase, F15B10.2a nst-1 16439208 intact exp Dicer-related helicase, F15B10.2a F52E4.1a 16439208 intact exp Dicer-related helicase, F15B10.2a rpa-1 16439208 intact exp Dicer-related helicase, F15B10.2a cct-1 16439208 intact exp Dicer-related helicase, F15B10.2a eef-2 16439208 intact exp Dicer-related helicase, F15B10.2a mos-2 16439208 intact exp Dicer-related helicase, F15B10.2a F01G10.1 16439208 intact exp Dicer-related helicase, F15B10.2a F30H5.3 16439208 intact exp Dicer-related helicase, F15B10.2a Y38F2AR.1a 16439208 intact exp Dicer-related helicase, F15B10.2a C50B6.3b 16439208 intact exp Dicer-related helicase, F15B10.2a Protein argonaute 16439208 intact exp Dicer-related helicase, F15B10.2a eri-1 16439208 intact exp Dicer-related helicase, F15B10.2a T06D8.8 16439208 intact exp Dicer-related helicase, F15B10.2a panl-3 16439208 intact exp Dicer-related helicase, F15B10.2a rop-1 16439208 intact exp Dicer-related helicase, F15B10.2a K08F4.2 16439208 intact exp Dicer-related helicase, F15B10.2a mrps-14 16439208 intact exp Dicer-related helicase, F15B10.2a sip-1 16439208 intact exp Dicer-related helicase, F15B10.2a W09B6.2 16439208 intact exp Dicer-related helicase, F15B10.2a C12C8.1 16439208 intact exp Dicer-related helicase, F15B10.2a atp-2 16439208 intact exp Dicer-related helicase, F15B10.2a Putative U5 small nuclear ribonucleoprotein 200 kDa helicase 16439208 intact exp Dicer-related helicase, F15B10.2a ech-1.2 16439208 intact exp Dicer-related helicase, F15B10.2a hsp-4 16439208 intact exp Dicer-related helicase, F15B10.2a C40A11.4 16439208 intact exp RNA interference promoting factor, T20G5.11 Dicer-related helicase, F15B10.2a 12110183,16439208 biogrid,intact exp Dicer-related helicase, F15B10.2a T05B4.11 16439208 intact exp Dicer-related helicase, F15B10.2a C55B7.4a 16439208 intact exp Dicer-related helicase, F15B10.2a Y46G5A.13 16439208 intact exp Dicer-related helicase, F15B10.2a mrps-31 16439208 intact exp Dicer-related helicase, F15B10.2a Y69H2.3b 16439208 intact exp Dicer-related helicase, F15B10.2a rps-12 16439208 intact exp Dicer-related helicase, F15B10.2a snr-3 16439208 intact exp R10E4.2q Dicer-related helicase, F15B10.2a 16439208 intact exp Dicer-related helicase, F15B10.2a retr-1 16439208 intact exp Dicer-related helicase, F15B10.2a rps-13 16439208 intact exp Dicer-related helicase, F15B10.2a C46H11.9 16439208 intact exp Dicer-related helicase, F15B10.2a tbb-4 16439208 intact exp Dicer-related helicase, F15B10.2a Cathepsin Z-like enzyme, F32B5.8a 16439208 intact exp T06D8.10 Dicer-related helicase, F15B10.2a 16439208 intact exp Dicer-related helicase, F15B10.2a Y75B8A.20 16439208 intact exp Dicer-related helicase, F15B10.2a T04A8.7a 16439208 intact exp Dicer-related helicase, F15B10.2a K10D3.4 16439208 intact exp Dicer-related helicase, F15B10.2a Y63D3A.5 16439208 intact exp Dicer-related helicase, F15B10.2a D2092.2 16439208 intact exp Dicer-related helicase, F15B10.2a F45E4.2 16439208 intact exp Dicer-related helicase, F15B10.2a cyn-6 16439208 intact exp Dicer-related helicase, F15B10.2a Dicer-related helicase, F15B10.2a 16439208 intact exp, ortho Dicer-related helicase, F15B10.2a pkc-2 ortho Dicer-related helicase, F15B10.2a Coiled-coil and C2 domain-containing protein 1-like ortho Dicer-related helicase, F15B10.2a CRAL-TRIO domain-containing protein T23G5.2 ortho Dicer-related helicase, F15B10.2a Autophagy protein 5 ortho Dicer-related helicase, F15B10.2a Ubiquitin carboxyl-terminal hydrolase ortho Dicer-related helicase, F15B10.2a rpl-8 ortho Dicer-related helicase, F15B10.2a ubq-2 ortho Dicer-related helicase, F15B10.2a let-70 ortho Dicer-related helicase, F15B10.2a Uncharacterized helicase C28H8.3 ortho Putative DEAD-box RNA helicase, Y71H2AM.19b Dicer-related helicase, F15B10.2a ortho Dicer-related helicase, F15B10.2a rpl-3 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants H2KYY3 G5EDI8 - 14704431 - X 2 G5EDI8 H2KYY9 two hybrid 14704431 direct interaction X 2 G5EBF5 G5EDI8 affinity chromatography technology 12110183 physical association X 2 Q95QA6 G5EDI8 two hybrid 14704431 physical association X 2 G5EDI8 molecular sieving 22179787 physical association C 3 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association C 3 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association C 3 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association C 3 G5EDI8 anti bait coimmunoprecipitation 22179787 - C 4 G5EDI8 anti tag coimmunoprecipitation 22179787 - C 4 G5EDI8 anti bait coimmunoprecipitation 22179787 - C 4 G5EDI8 anti tag coimmunoprecipitation 22179787 - C 4 G5EDI8 anti bait coimmunoprecipitation 22179787 - C 4 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EDI8 G5EEH0 anti tag coimmunoprecipitation 22179787 physical association X 2 G5EDI8 G5EEH0 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EBF5 G5EDI8 anti tag coimmunoprecipitation 22179787 physical association X 2 G5EBF5 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EBF5 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EBF5 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EBF5 G5EDI8 anti bait coimmunoprecipitation 22179787 physical association X 2 G5EDI8 anti tag coimmunoprecipitation 16439208 association C 6 G5EDI8 H2KYY5 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B rde-4 drh-1 MI:0004(affinity chromatography technology) 12110183 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (biogrid) BIOGRID_29638 bait prey pat-12 drh-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_24141 bait prey drh-1 pat-12 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_28036 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9GZI7 G5EDI8 ERI-3 DRH-1 0.236 16439208 G5EDI8 G5EDI8 DRH-1 DRH-1 0.286 16439208 Q9GZI6 G5EDI8 TAF-6.1 DRH-1 0.236 16439208 Q22707 G5EDI8 PIR-1 DRH-1 0.236 16439208 Q93413 G5EDI8 DRH-3 DRH-1 0.236 16439208 G5EDI8 A3QMD6 DRH-1 A3QMD6 0.126 16439208 G5EDI8 G5EBF5 DRH-1 RDE-4 0.126 16439208 G5EDI8 G5ECK5 DRH-1 G5ECK5 0.126 16439208 G5EE04 G5EDI8 HIP-1 DRH-1 0.126 16439208 G5EE53 G5EDI8 RRF-3 DRH-1 0.126 16439208 G5EEH0 G5EDI8 RDE-1 DRH-1 0.126 16439208 G5EGP8 G5EDI8 CPZ-1 DRH-1 0.126 16439208 G5EGR6 G5EDI8 ALG-1 DRH-1 0.126 16439208 H2KYS8 G5EDI8 CPNA-1 DRH-1 0.126 16439208 H2KZG6 G5EDI8 ACDH-1 DRH-1 0.126 16439208 O02042 G5EDI8 MDT-1.2 DRH-1 0.126 16439208 O16420 G5EDI8 PHAT-5 DRH-1 0.126 16439208 O16720 G5EDI8 ALG-2 DRH-1 0.126 16439208 O17689 G5EDI8 O17689 DRH-1 0.126 16439208 O17732 G5EDI8 PYC-1 DRH-1 0.126 16439208 O17759 G5EDI8 TKT-1 DRH-1 0.126 16439208 O17953 G5EDI8 DLD-1 DRH-1 0.126 16439208 O44406 G5EDI8 ERI-1 DRH-1 0.236 16439208 O45246 G5EDI8 HSP-70 DRH-1 0.126 16439208 O45546 G5EDI8 O45546 DRH-1 0.126 16439208 P17330 G5EDI8 GPD-3 DRH-1 0.126 16439208 P20163 G5EDI8 HSP-4 DRH-1 0.126 16439208 P27420 G5EDI8 HSP-3 DRH-1 0.126 16439208 P29691 G5EDI8 EEF-2 DRH-1 0.126 16439208 P34431 G5EDI8 RETR-1 DRH-1 0.126 16439208 P34653 G5EDI8 PANL-3 DRH-1 0.126 16439208 P41937 G5EDI8 TBB-4 DRH-1 0.126 16439208 P41988 G5EDI8 CCT-1 DRH-1 0.126 16439208 P46561 G5EDI8 ATP-2 DRH-1 0.126 16439208 P47207 G5EDI8 CCT-2 DRH-1 0.126 16439208 P49196 G5EDI8 RPS-12 DRH-1 0.126 16439208 P49391 G5EDI8 MRPS-14 DRH-1 0.126 16439208 P50140 G5EDI8 HSP-60 DRH-1 0.126 16439208 P51404 G5EDI8 RPS-13 DRH-1 0.126 16439208 P52014 G5EDI8 CYN-6 DRH-1 0.126 16439208 P91198 G5EDI8 PPFR-2 DRH-1 0.126 16439208 P91277 G5EDI8 P91277 DRH-1 0.126 16439208 P91918 G5EDI8 SNR-2 DRH-1 0.126 16439208 Q09261 G5EDI8 MRPS-31 DRH-1 0.126 16439208 Q09983 G5EDI8 Q09983 DRH-1 0.126 16439208 Q10013 G5EDI8 SNR-3 DRH-1 0.126 16439208 Q17411 G5EDI8 Q17411 DRH-1 0.126 16439208 Q18572 G5EDI8 Q18572 DRH-1 0.126 16439208 Q19537 G5EDI8 RPA-1 DRH-1 0.126 16439208 Q19790 G5EDI8 DUR-1 DRH-1 0.126 16439208 Q20168 G5EDI8 Q20168 DRH-1 0.126 16439208 Q20363 G5EDI8 SIP-1 DRH-1 0.126 16439208 Q20627 G5EDI8 PAM-1 DRH-1 0.126 16439208 Q20676 G5EDI8 PCCB-1 DRH-1 0.126 16439208 Q20772 G5EDI8 Q20772 DRH-1 0.126 16439208 Q21086 G5EDI8 NST-1 DRH-1 0.126 16439208 Q21351 G5EDI8 GTBP-1 DRH-1 0.126 16439208 Q21418 G5EDI8 Q21418 DRH-1 0.126 16439208 Q21605 G5EDI8 ZBP-1 DRH-1 0.126 16439208 Q21900 G5EDI8 SUP-26 DRH-1 0.126 16439208 Q21924 G5EDI8 MOS-2 DRH-1 0.126 16439208 Q22137 G5EDI8 Q22137 DRH-1 0.126 16439208 Q22253 G5EDI8 RPN-9 DRH-1 0.126 16439208 Q23155 G5EDI8 MRPS-11 DRH-1 0.126 16439208 Q27274 G5EDI8 ROP-1 DRH-1 0.126 16439208 Q27527 G5EDI8 ENOL-1 DRH-1 0.126 16439208 Q86S29 G5EDI8 CCT-7 DRH-1 0.126 16439208 Q86S66 G5EDI8 Q86S66 DRH-1 0.126 16439208 Q8I4B8 G5EDI8 Q8I4B8 DRH-1 0.126 16439208 Q8ITW7 G5EDI8 Q8ITW7 DRH-1 0.126 16439208 Q8MQ25 G5EDI8 Q8MQ25 DRH-1 0.126 16439208 Q8T8N8 G5EDI8 Q8T8N8 DRH-1 0.126 16439208 Q93537 G5EDI8 PLP-2 DRH-1 0.126 16439208 Q94230 G5EDI8 PLP-1 DRH-1 0.126 16439208 Q95QA6 G5EDI8 PAT-12 DRH-1 0.126 14704431 Q95QU3 G5EDI8 ERI-9 DRH-1 0.126 16439208 Q95XS0 G5EDI8 ERI-5 DRH-1 0.126 16439208 Q965Q1 G5EDI8 Q965Q1 DRH-1 0.126 16439208 Q9GYJ2 G5EDI8 PHAT-2 DRH-1 0.126 16439208 Q9N358 G5EDI8 CCT-8 DRH-1 0.126 16439208 Q9NLD1 G5EDI8 HRP-2 DRH-1 0.126 16439208 Q9TZB0 G5EDI8 Q9TZB0 DRH-1 0.126 16439208 Q9TZI2 G5EDI8 ZTF-4 DRH-1 0.126 16439208 Q9U1W1 G5EDI8 TFG-1 DRH-1 0.126 16439208 Q9U2F5 G5EDI8 TIAR-2 DRH-1 0.126 16439208 Q9U2G0 G5EDI8 Q9U2G0 DRH-1 0.126 16439208 Q9U489 G5EDI8 LIN-41 DRH-1 0.126 16439208 Q9XVS2 G5EDI8 Q9XVS2 DRH-1 0.126 16439208 Q9XW83 G5EDI8 GRL-15 DRH-1 0.126 16439208