PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus fem-3 Y82E9BR.15 17609115 biogrid,intact exp zif-1 Y82E9BR.15 12894212 intact exp F08G12.4 Y82E9BR.15 17304241 biogrid,intact exp F33G12.4 Y82E9BR.15 20978077 biogrid exp 3L686 Y82E9BR.15 18692475,unassigned701,14704431 biogrid,intact exp tra-1 Y82E9BR.15 17609115 biogrid,intact exp fem-2 Y82E9BR.15 17609115 biogrid,intact exp R09E10.7 Y82E9BR.15 24012004 biogrid exp fem-1 Y82E9BR.15 17609115 biogrid,intact exp zyg-11 Y82E9BR.15 17304241 biogrid,mint,intact exp, ortho zer-1 Y82E9BR.15 17304241 biogrid,mint,intact exp, ortho cul-2 Y82E9BR.15 17609115,17304241 biogrid,mint,intact exp, ortho ctr-9 Y82E9BR.15 ortho Y82E9BR.15 Y39E4B.1 ortho csn-6 Y82E9BR.15 ortho F48E8.7a Y82E9BR.15 ortho Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 Y82E9BR.15 ortho cul-5 Y82E9BR.15 ortho Probable DNA topoisomerase 2 Y82E9BR.15 ortho dgk-5 Y82E9BR.15 ortho F49D11.9 Y82E9BR.15 ortho rbx-1 Y82E9BR.15 ortho D2023.4 Y82E9BR.15 ortho snr-2 Y82E9BR.15 ortho Ras2 Y82E9BR.15 ortho rack-1 Y82E9BR.15 ortho Probable protein ariadne-2, Ari-2 Y82E9BR.15 ortho F53E4.1a Y82E9BR.15 ortho Y82E9BR.15 C29F9.7 ortho R10A10.2 Y82E9BR.15 ortho Y82E9BR.15 Y71H2AM.1 ortho W02B12.8a Y82E9BR.15 ortho csn-5 Y82E9BR.15 ortho R119.5a Y82E9BR.15 ortho cul-3 Y82E9BR.15 ortho Y82E9BR.15 DNA helicase ortho Y82E9BR.15 Y82E9BR.15 ortho B0205.3 Y82E9BR.15 ortho ned-8 Y82E9BR.15 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9BKS1 G5ECR7 - 14704431 - X 2 P49594 Q9BKS1 affinity chromatography technology 17609115 physical association X 2 P34691 Q9BKS1 affinity chromatography technology 17609115 physical association X 2 Q9BKS1 Q17390-2 affinity chromatography technology 17304241 physical association X 2 Q9BKS1 Q19213 two hybrid 17304241 direct interaction X 2 Q9BKS1 Q2WF59 two hybrid 17304241 direct interaction X 2 Q9BKS1 Q17390-2 affinity chromatography technology 17609115 physical association X 2 Q9BKS1 Q19988 affinity chromatography technology 20978077 physical association X 2 Q9BKS1 two hybrid 24012004 direct interaction X 2 Q9BKS1 G5ECR7 two hybrid 18692475 direct interaction X 2 Q9BKS1 G5ECR7 two hybrid 18692475 direct interaction X 2 Q9BKS1 P17221 affinity chromatography technology 17609115 physical association X 2 Q9BKS1 P17221 affinity chromatography technology 17609115 physical association X 2 Q9BKS1 Q13617 affinity chromatography technology 17609115 physical association X 2 Q9BKS1 P34708-2 affinity chromatography technology 17609115 physical association X 2 Q9BKS1 G5ECR7 two hybrid 14704431 direct interaction X 2 P21541 Q9BKS1 affinity chromatography technology 17304241 physical association X 2 Q9BKS1 G5ECR7 two hybrid 14704431 physical association X 2 Q9BKS1 anti tag coimmunoprecipitation 17609115 physical association C 9 Q9BKS1 P34482 two hybrid 12894212 physical association X 2 Q9BKS1 Q19213 two hybrid 17304241 physical association X 2 Q9BKS1 Q2WF59 two hybrid 17304241 physical association X 2 Q9BKS1 anti tag coimmunoprecipitation 17609115 physical association C 6 Q9BKS1 G5ECR7 two hybrid pooling approach 14704431 physical association X 2 Q9BKS1 P17221 anti tag coimmunoprecipitation 17609115 physical association X 2 Q9BKS1 P17221 pull down 17609115 physical association X 2 Q9BKS1 G5ECR7 two hybrid - physical association X 2 Q9BKS1 G5ECR7 two hybrid - physical association X 2 P21541 Q9BKS1 two hybrid 17304241 physical association X 2 P21541 Q9BKS1 pull down 17304241 physical association X 2 Q17390 Q9BKS1 pull down 17304241 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B fem-2 elc-1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17609115 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_92674|UniProt_168|BIOGRID_29403 prey|prey|prey bait|bait|bait zyg-11 elc-1 MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 17304241 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint) 651637|UniProt_1489|UniProt_1488|MINT_3839|651642|UniProt_90094|MINT_3840|BIOGRID_28515|MINT_3841 prey|bait|prey|prey|bait|bait|prey|prey|bait bait|prey|bait|bait|prey|prey|bait|bait|prey tra-1 elc-1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17609115 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_92674|UniProt_168|BIOGRID_29405 null|null|prey bait|bait|bait fem-1 elc-1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 17609115 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact) UniProt_92666|UniProt_160|UniProt_169|UniProt_92674|UniProt_168 bait|bait|prey|prey|prey prey|prey|bait|bait|bait elc-1 Q9XWU4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431,18692475 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0465(dip)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_5938|MINT_6301|MINT_5936|MINT_5937|MINT_6300|MINT_5935|MINT_6302|MINT_5933|DIP_4435|MINT_6298|MINT_2957|MINT_6299|MINT_5931|MINT_5930|MINT_6297 prey|bait|prey|prey|bait|prey|bait|prey|-|bait|prey|bait|prey|prey|bait bait|prey|bait|bait|prey|bait|prey|bait|-|prey|bait|prey|bait|bait|prey fem-3 elc-1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17609115 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid) UniProt_92674|UniProt_168|BIOGRID_29402 prey|prey|prey bait|bait|bait zif-1 elc-1 MI:0018(two hybrid) 12894212 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_216 bait prey elc-1 elb-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_24949|UniProt_24716|UniProt_28824 prey|bait|prey bait|prey|bait zer-1 elc-1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 17304241 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|(intact)|(intact) BIOGRID_28520|MINT_3842|UniProt_90096|651651|UniProt_1491 bait|bait|bait|bait|bait prey|prey|prey|prey|prey vhl-1 elc-1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 17304241 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(biogrid) UniProt_90095|UniProt_1490|651648|BIOGRID_28518 bait|bait|bait|bait prey|prey|prey|prey cul-2 elc-1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 17304241,17609115 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|MI:0471(mint)|(biogrid)|(intact)|(biogrid) UniProt_159|UniProt_1487|MINT_3838|BIOGRID_29388|651632|BIOGRID_28516 bait|prey|prey|bait|prey|prey prey|bait|bait|prey|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BKS1 Q19213 ELC-1 VHL-1 0.309 17304241 Q9BKS1 G5ECR7 ELC-1 ELB-1 0.286 14704431,unassigned701 Q9XWU4 Q9BKS1 Q9XWU4 ELC-1 0.21 14704431,18692475 Q9BKS1 P21541 ELC-1 ZYG-11 0.454 17304241 Q9BKS1 P34482 ELC-1 ZIF-1 0.309 12894212 Q9BKS1 Q2WF59 ELC-1 ZER-1 0.309 17304241 Q9BKS1 Q17390 ELC-1 CUL-2 0.21 17304241