PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus gad-1 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial 14704431 biogrid,i2d,mint,intact,dip exp G gad-1 nhr-111 19123269,14704431 biogrid,i2d,mint,intact,dip exp W05H7.4e gad-1 14704431 biogrid,intact,dip exp G gad-1 F54D10.7 12445390,14704431 biogrid,i2d,mint,intact exp gad-1 cyc-2.1 14704431 biogrid,i2d exp G gad-1 snpc-1.4 19123269 intact exp gad-1 T04D3.1 19123269 intact exp Y66D12A.16a gad-1 14704431 biogrid exp gad-1 Y59A8B.10a 14704431 biogrid,i2d,mint,intact,dip exp G gad-1 Y62E10A.14 12445390,14704431 biogrid,i2d,mint,intact exp gad-1 T08G5.5b 14704431 biogrid,i2d,mint,intact,dip exp G gad-1 F54C9.11 19123269 intact exp G gad-1 C25G4.4 14704431 biogrid,i2d,mint,intact,dip exp gad-1 F52C6.3 12445390,14704431 biogrid,mint,intact exp C06A5.9 gad-1 14704431 biogrid,i2d,mint,intact,dip exp gad-1 rpl-20 14704431 i2d,mint,intact exp DNA-binding protein LAG-1, K08B4.1a, Lag-1 protein gad-1 ortho G cdc-37 gad-1 ortho G gad-1 ZK742.1a ortho G gad-1 wdr-48 ortho G chp gad-1 ortho G ten-1 gad-1 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q18171 O16519 - 14704431 - X 2 O16519 - 12445390 - X 2 O45603 O16519 - 12445390 - X 2 O16519 - 14704431 - X 2 O16519 Q9GRY9 - 14704431 - X 2 O16519 Q9XUQ4 - 14704431 - X 2 O16519 - 14704431 - X 2 O16519 - 14704431 - X 2 O16519 - 14704431 - X 2 O16519 - 14704431 - X 2 O16519 Q9TZ84 - 12445390 - X 2 O16519 Q19749 - 14704431 - X 2 Q18171 O16519 two hybrid 14704431 direct interaction X 2 O44820 O16519 two hybrid 12445390 direct interaction X 2 O44820 O16519 two hybrid 14704431 direct interaction X 2 O45603 O16519 two hybrid 12445390 direct interaction X 2 O45603 O16519 two hybrid 14704431 direct interaction X 2 O16519 O01482 two hybrid 14704431 direct interaction X 2 O16519 Q9XUQ4 two hybrid 14704431 direct interaction X 2 O16519 H2KZI3 two hybrid 14704431 direct interaction X 2 O16519 Q9GRY9 two hybrid 14704431 direct interaction X 2 O16519 A7DTF6 two hybrid 14704431 direct interaction X 2 O16519 two hybrid 14704431 direct interaction X 2 O16519 Q9TZ84 two hybrid 12445390 direct interaction X 2 O16519 Q19749 two hybrid 14704431 direct interaction X 2 O16519 O45521 two hybrid 14704431 direct interaction X 2 O16519 Q9TZ84 two hybrid 14704431 direct interaction X 2 Q18171 O16519 two hybrid 14704431 physical association X 2 O16519 O01482 two hybrid 14704431 physical association X 2 O16519 two hybrid 14704431 physical association X 2 O16519 Q9XUQ4 two hybrid 14704431 physical association X 2 O16519 Q9GRY9 two hybrid 14704431 physical association X 2 O16519 two hybrid 14704431 physical association X 2 O44480 O16519 two hybrid 14704431 physical association X 2 O02174 O16519 two hybrid 14704431 physical association X 2 O16519 Q19749 two hybrid 14704431 physical association X 2 Q18171 O16519 two hybrid pooling approach 14704431 physical association X 2 O44820 O16519 two hybrid 12445390 physical association X 2 O45603 O16519 two hybrid 12445390 physical association X 2 O16519 Q9XUQ4 two hybrid pooling approach 14704431 physical association X 2 O16519 H2KZI3 two hybrid pooling approach 14704431 physical association X 2 O16519 Q9GRY9 two hybrid pooling approach 14704431 physical association X 2 O16519 O01482 two hybrid pooling approach 14704431 physical association X 2 O16519 Q20759 two hybrid pooling approach 19123269 physical association X 2 O16519 Q21747 two hybrid pooling approach 19123269 physical association X 2 O16519 Q20759 two hybrid array 19123269 physical association X 2 O16519 Q21747 two hybrid array 19123269 physical association X 2 O44480 O16519 two hybrid pooling approach 14704431 physical association X 2 O16519 Q9TZ84 two hybrid 12445390 physical association X 2 O16519 Q19749 two hybrid pooling approach 14704431 physical association X 2 O16519 O45521 two hybrid pooling approach 14704431 physical association X 2 O16519 O45521 two hybrid pooling approach 19123269 physical association X 2 O16519 O18697 two hybrid pooling approach 19123269 physical association X 2 O16519 O45521 two hybrid array 19123269 physical association X 2 O16519 O18697 two hybrid array 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B gad-1 Q95Q01 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_1963|UniProt_27874 bait|bait prey|prey rnf-1 gad-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|MI:0471(mint)|(intact) BIOGRID_23969|DIP_3479|MINT_1952|UniProt_27868 prey|-|prey|prey bait|-|bait|bait gad-1 Q8MPS9 MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_1961 bait prey gad-1 COI MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:190499() MI:0407(direct interaction) (biogrid) BIOGRID_23980 bait prey gad-1 T04D3.1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19463|UniProt_21378 bait|bait prey|prey gad-1 Y66D12A.16 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_3487 - - zfp-3 gad-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0465(dip) DIP_3485 - - gad-1 CELE_H02I12.5 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 12445390 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_426|MINT_1959 bait|bait prey|prey gad-1 rpl-20 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0465(dip) MINT_1954|UniProt_27869|DIP_3481 bait|bait|- prey|prey|- gad-1 nhr-111 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(intact)|MI:0471(mint)|(intact)|(biogrid)|(intact) DIP_3483|UniProt_27870|MINT_1956|UniProt_20883|BIOGRID_23973|UniProt_18969 -|bait|bait|bait|bait|bait -|prey|prey|prey|prey|prey gad-1 zfp-3 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_27872 bait prey gad-1 F52C6.3 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 12445390 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_1957|UniProt_424 bait|bait prey|prey gad-1 btbd-10 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_21273|UniProt_19364 bait|bait prey|prey gad-1 Y59A8B.10 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|MI:0471(mint)|(intact) BIOGRID_23979|DIP_3486|MINT_1962|UniProt_27875 bait|-|bait|bait prey|-|prey|prey gad-1 F54D10.7 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 12445390,14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(biogrid)|(biogrid) UniProt_425|MINT_1958|BIOGRID_23975|BIOGRID_25778 bait|bait|bait|bait prey|prey|prey|prey gad-1 F23B12.5 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|MI:0465(dip) MINT_1955|UniProt_27871|BIOGRID_23972|DIP_3482 bait|bait|bait|- prey|prey|prey|- gad-1 cyc-2.1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_23971 bait prey gad-1 CELE_F54C9.11 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19096|UniProt_21008 bait|bait prey|prey gad-1 gmeb-4 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0465(dip)|(intact) MINT_1953|BIOGRID_23970|DIP_3480|UniProt_27867 bait|bait|-|bait prey|prey|-|prey gad-1 vps-39 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0465(dip)|MI:0471(mint) UniProt_27873|DIP_3484|MINT_1960 bait|-|bait prey|-|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q19749 O16519 Q19749 GAD-1 0.309 14704431 O44820 O16519 O44820 GAD-1 0.183 12445390 O45603 O16519 O45603 GAD-1 0.183 12445390 O44480 O16519 RPL-20 GAD-1 0.126 14704431 O16519 O02174 GAD-1 ZFP-3 0.033 14704431 Q9XUQ4 O16519 VPS-39 GAD-1 0.155 14704431 P19974 O16519 CYC-2.1 GAD-1 0.183 14704431 Q9GRY9 O16519 Q9GRY9 GAD-1 0.155 14704431 Q18171 O16519 SPE-44 GAD-1 0.155 14704431 Q20759 O16519 Q20759 GAD-1 0.236 19123269 Q21747 O16519 BTBD-10 GAD-1 0.236 19123269 O18697 O16519 O18697 GAD-1 0.236 19123269 O45521 O16519 NHR-111 GAD-1 0.472 19123269,14704431 Q95Q01 O16519 Q95Q01 GAD-1 0.033 14704431 Q9TZ84 O16519 Q9TZ84 GAD-1 0.183 12445390 O16519 H2KZI3 GAD-1 ZFP-3 0.126 14704431 O16519 A0A0K3AUY4 GAD-1 A0A0K3AUY4 0.126 14704431 O16519 O01482 GAD-1 RNF-1 0.155 14704431