PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus let-70 cyp-31a3 i2d exp let-70 Uncharacterized RING finger protein T02C1.1 i2d exp rfp-1 let-70 i2d exp G let-70 F35G12.9 i2d exp G C45G7.4 let-70 i2d exp let-70 otub-1 14704431 i2d,mint,intact,dip exp G let-70 F43G6.8 i2d exp G cyp-31a2 let-70 14704431 biogrid,intact exp G let-70 F54B11.5 i2d exp G let-70 nhl-1 i2d exp C36A4.8a let-70 16628214 biogrid exp G C25D7.10 let-70 14704431 biogrid exp G let-70 Y51F10.2a 18692475,unassigned701 biogrid,mint,intact exp G let-70 prx-12 i2d exp let-70 F16A11.1a i2d exp, ortho G let-70 F55A3.1 ortho G General transcription factor IIH subunit 2 let-70 ortho G let-70 smo-1 ortho G Zinc finger protein ZPR1 homolog let-70 ortho G let-70 T07F12.1 ortho let-70 rbx-1 ortho G let-70 ufd-2 ortho let-70 C17H12.14 ortho G let-70 siah-1 ortho G R06A4.4a let-70 ortho let-70 par-4 ortho let-70 R10A10.2 ortho G let-70 rnf-5 ortho G hmp-2 let-70 ortho G let-70 cul-3 ortho G let-70 T07D1.2 ortho G rps-17 let-70 ortho G let-70 ncs-2 ortho G let-70 ubc-12 ortho G let-70 let-70 ortho G let-70 cul-1 ortho G Y92H12A.2a let-70 ortho G let-70 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial ortho G let-70 C47E12.5a ortho G let-70 rps-7 ortho G tag-277 let-70 ortho G let-70 C18B12.4 ortho G let-70 Probable protein ariadne-2, Ari-2 ortho G ubq-1 let-70 ortho G let-70 sel-11 ortho G let-70 S-methyl-5'-thioadenosine phosphorylase ortho G let-70 ZK1307.6 ortho 1G758 let-70 ortho G let-70 hrdl-1 ortho G let-70 pbs-4 ortho G let-70 epg-4 ortho G let-70 ned-8 ortho G let-70 Y71G12B.15a ortho G Dicer-related helicase, F15B10.2a let-70 ortho let-70 rps-5 ortho G let-70 K08E3.7a ortho G chc-1 let-70 ortho G let-70 arc-1 ortho G F39B2.2 let-70 ortho G let-70 ggtb-1 ortho G let-70 dcaf-1 ortho G let-70 ubq-2 ortho G let-70 nfx-1 ortho G F53G2.7 let-70 ortho G let-70 C01G6.4 ortho G rpn-11 let-70 ortho G let-70 rrbs-1 ortho G C34F11.3c let-70 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P35129 - 15530417 - X 2 P35129 - 15530417 - X 2 P35129 - 15530417 - X 2 P35129 P34537-2 - 15530417 - X 2 P35129 Q20737 - 15530417 - X 2 Q20369 P35129 - 15530417 - X 2 Q19189 P35129 - 15530417 - X 2 P35129 Q03601 - 15530417 - X 2 P35129 - 15530417 - X 2 P35129 - 15530417 - X 2 Q20052 P35129 - 15530417 - X 2 P35129 Q8WTJ8 two hybrid 18692475 direct interaction X 2 P35129 biochemical 16628214 association X 2 P35129 two hybrid 14704431 direct interaction X 2 P35129 G5EGT6 two hybrid 14704431 direct interaction X 2 P35129 Q9XVR6 two hybrid 14704431 physical association X 2 P35129 G5EGT6 two hybrid 14704431 physical association X 2 P35129 Q9XVR6 two hybrid pooling approach 14704431 physical association X 2 P35129 Q8WTJ8 two hybrid - physical association X 2 P35129 G5EGT6 two hybrid pooling approach 14704431 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B O45605 let-70 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:0() taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip) MINT_1054|DIP_2645 bait|- prey|- let-70 Y51F10.2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint) UniProt_25293|BIOGRID_29283|MINT_5275 bait|bait|bait prey|prey|prey let-70 cyp-31a2 MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_31029 prey bait C25D7.10 let-70 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_21692 bait prey let-70 otub-1 MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0465(dip) UniProt_29820|MINT_7012|DIP_1437 prey|prey|- bait|bait|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9XVR6 P35129 OTUB-1 LET-70 0.155 14704431 Q8WTJ8 P35129 Q8WTJ8 LET-70 0.332 unassigned701,18692475 P35129 G5EGT6 LET-70 CYP-31A2 0.155 14704431