PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Uncharacterized protein C06E1.1 lgg-1 19123269 intact exp lgg-1 Y46G5A.18a 19123269 intact exp lgg-1 C27A2.6 21110867 intact exp lgg-1 C06G1.4 23619095 intact exp G lgg-1 R102.5b 19123269 intact exp G lgg-1 nhr-31 19123269 intact exp G M01E5.6 lgg-1 19167332 intact exp F20C5.6 lgg-1 19123269 intact exp G klp-6 lgg-1 14704431 biogrid,mint,intact exp G lgg-1 Y87G2A.3a 19123269,14704431 biogrid,i2d,mint,intact,dip exp, ortho G lgg-1 ZK792.8 i2d exp, ortho G D1081.8 lgg-1 ortho G lgg-1 rpa-0 ortho G lgg-1 Putative U5 small nuclear ribonucleoprotein 200 kDa helicase ortho G lgg-1 syx-5 ortho G R06B10.5 lgg-1 ortho F09E5.15b lgg-1 ortho G lgg-1 T07A9.11 ortho G lgg-1 rps-16 ortho G lgg-1 Y105E8A.16 ortho G uba-5 lgg-1 ortho G lgg-1 vdac-1 ortho G Calcium-transporting ATPase lgg-1 ortho G cyn-1 lgg-1 ortho G sel-9 lgg-1 ortho G lgg-1 T08G11.1a ortho G atp-2 lgg-1 ortho G Serine/threonine-protein phosphatase lgg-1 ortho G lgg-1 F37C12.13a ortho G Y45F10A.6a lgg-1 ortho tRNA-splicing ligase RtcB homolog lgg-1 ortho G aldo-1 lgg-1 ortho G lgg-1 Proteasome subunit beta type ortho G F22G12.4a lgg-1 ortho lgg-1 F27C1.7b ortho G Y48E1C.3 lgg-1 ortho lgg-1 rsp-3 ortho G CTP synthase lgg-1 ortho lgg-1 ZC518.2 ortho G lgg-1 F43G9.5 ortho G lgg-1 T24F1.3a ortho G lgg-1 C53D5.6 ortho G rpl-22 lgg-1 ortho G lgg-1 rps-6 ortho G eef-1B.1 lgg-1 ortho G lgg-1 paa-1 ortho G lgg-1 rps-9 ortho G lgg-1 rha-1 ortho G rpl-19 lgg-1 ortho G rpl-6 lgg-1 ortho G lgg-1 Coatomer subunit beta ortho G F53G12.1 lgg-1 ortho G tbb-4 lgg-1 ortho G lgg-1 C44B7.2a ortho Putative DEAD-box RNA helicase, Y71H2AM.19b lgg-1 ortho G lgg-1 F25B4.5 ortho G lgg-1 rop-1 ortho G crt-1 lgg-1 ortho G lgg-1 F47G9.1 ortho G chc-1 lgg-1 ortho G Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit, Oligosaccharyl transferase 48 kDa subunit lgg-1 ortho G lgg-1 snr-7 ortho G K02F2.3 lgg-1 ortho G eef-2 lgg-1 ortho G rpl-18 lgg-1 ortho G lgg-1 ZC155.7 ortho G lgg-1 Y69A2AR.18b ortho G kin-10 lgg-1 ortho G mdh-2 lgg-1 ortho G lgg-1 daf-21 ortho G lgg-1 D2085.1 ortho G R06A4.8 lgg-1 ortho G rps-3 lgg-1 ortho G lgg-1 Y47D3A.4 ortho ahcy-1 lgg-1 ortho G lgg-1 arf-1.2 ortho G rps-13 lgg-1 ortho G lgg-1 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase F56D2.6 ortho G rpl-13 lgg-1 ortho G lgg-1 F58E10.3a ortho G lgg-1 Putative serine/threonine-protein kinase C05D10.2 ortho G lgg-1 F49E10.1 ortho G rpl-27 lgg-1 ortho G alx-1 lgg-1 ortho G lgg-1 Autophagy protein 5 ortho G lgg-1 Serrate RNA effector molecule homolog ortho G rpl-24.1 lgg-1 ortho G cct-2 lgg-1 ortho G F33H2.2 lgg-1 ortho G uaf-1 lgg-1 ortho G lgg-1 krs-1 ortho G lgg-1 gos-28 ortho lgg-1 F22D3.2c ortho G Y110A7A.9a lgg-1 ortho G rpl-5 lgg-1 ortho G lgg-1 rpl-17 ortho G lgg-1 M03A8.2 ortho lgg-1 F38B6.4 ortho G lgg-1 R151.7a ortho G lgg-1 ZK328.2 ortho G lgg-1 cul-3 ortho G lgg-1 K07E3.4a, K07E3.4b ortho G lgg-1 Uncharacterized protein F07F6.4 ortho ama-1 lgg-1 ortho pbs-6 lgg-1 ortho G hsp-1 lgg-1 ortho G lgg-1 R12H7.2 ortho G lgg-1 enol-1 ortho cap-2 lgg-1 ortho G lgg-1 ZK742.1a ortho G C44E4.4 lgg-1 ortho G F31D4.2 lgg-1 ortho G lgg-1 tag-320 ortho G lgg-1 tpi-1 ortho G lgg-1 let-268 ortho lgg-1 rps-7 ortho G rps-17 lgg-1 ortho G lgg-1 lgg-2 ortho G lgg-1 Y69A2AR.7a ortho G lgg-1 mcm-5 ortho lgg-1 Y113G7A.3 ortho G lgg-1 spt-16 ortho G C26H9A.2c lgg-1 ortho G lgg-1 rps-4 ortho G lgg-1 Y56A3A.21 ortho G F56H1.4 lgg-1 ortho G lgg-1 Y106G6H.3a ortho G rpl-21 lgg-1 ortho G lgg-1 Probable coatomer subunit gamma ortho G lgg-1 C17E4.5 ortho G rps-14 lgg-1 ortho G lgg-1 C34C6.6a ortho hsp-60 lgg-1 ortho G F32H2.5 lgg-1 ortho G dld-1 lgg-1 ortho G lgg-1 snr-4 ortho G rps-5 lgg-1 ortho G T23H2.1 lgg-1 ortho T04C9.4b lgg-1 ortho G T28H10.3 lgg-1 ortho G Uncharacterized protein B0303.3 lgg-1 ortho G lgg-1 pkc-3 ortho G C31C9.2 lgg-1 ortho G lgg-1 xrn-2 ortho G Deoxyuridinetriphosphatase, K07A1.2 lgg-1 ortho G lgg-1 F02G3.1c ortho G rps-8 lgg-1 ortho G Cell division protein kinase 5, T27E9.3 lgg-1 ortho G lin-53 lgg-1 ortho G T10G3.6a lgg-1 ortho G cct-4 lgg-1 ortho G lgg-1 snr-3 ortho G lgg-1 C07H6.4 ortho G lgg-1 rab-33 ortho G lgg-1 F23C8.6 ortho G lgg-1 rpl-9 ortho G pbs-4 lgg-1 ortho G lgg-1 F12F6.6 ortho G rpl-12 lgg-1 ortho G rps-2 lgg-1 ortho G lgg-1 T-complex protein 1 subunit gamma ortho Uncharacterized protein C30C11.4 lgg-1 ortho G lgg-1 cct-8 ortho G rpl-3 lgg-1 ortho G top-1 lgg-1 ortho G lgg-1 Y22D7AL.10 ortho G rpl-4 lgg-1 ortho G lgg-1 phb-1 ortho G lgg-1 mlc-5 ortho G Protein disulfide-isomerase lgg-1 ortho G dhhc-6 lgg-1 ortho G R11H6.5 lgg-1 ortho G lgg-1 Probable multifunctional protein ADE2, AIRC ortho G cnx-1 lgg-1 ortho G F35H12.2b lgg-1 ortho G lgg-1 rps-23 ortho G lgg-1 rpl-10a ortho G cmd-1 lgg-1 ortho G lgg-1 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial ortho G lgg-1 Probable signal recognition particle subunit SRP68, SRP68 ortho G lgg-1 Y55F3BR.1 ortho G lgg-1 Y113G7B.17 ortho G lgg-1 gsy-1 ortho G eef-1G lgg-1 ortho G lgg-1 dif-1 ortho G lgg-1 sdhb-1 ortho G lgg-1 fln-1 ortho G hsp-6 lgg-1 ortho G lgg-1 Annexin ortho G lgg-1 Y54H5A.1 ortho G pgk-1 lgg-1 ortho G vps-26 lgg-1 ortho G Y92H12A.2a lgg-1 ortho G lgg-1 rpl-16 ortho G lgg-1 Autophagy-related protein 3 ortho G lgg-1 T22D1.10 ortho G lgg-1 F01G4.2a ortho G lgg-1 JC8.2 ortho G lgg-1 C04F12.4 ortho G lgg-1 rpl-10 ortho G lgg-1 Y105E8B.5 ortho G K11C4.3c lgg-1 ortho G lgg-1 C39F7.4 ortho G lgg-1 ldh-1 ortho G lgg-1 C36B1.3 ortho lgg-1 snr-1 ortho G lgg-1 M03A8.1 ortho G Y57G11C.16 lgg-1 ortho G rab8 lgg-1 ortho G atg-7 lgg-1 ortho G lgg-1 K10B3.10b ortho G lgg-1 D1014.3 ortho G lgg-1 Y56A3A.32a ortho G 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial lgg-1 ortho G lgg-1 F55A4.1 ortho G Ceprp21 lgg-1 ortho G cct-1 lgg-1 ortho G lgg-1 W02D3.11a ortho G pas-1 lgg-1 ortho G lgg-1 enpl-1 ortho G lgg-1 Y47H9C.5a ortho lgg-1 D2089.4a ortho G unc-32 lgg-1 ortho G lgg-1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 ortho G lgg-1 cri-3 ortho G lgg-1 Receptor expression-enhancing protein ortho G lgg-1 prdx-3 ortho G lgg-1 rpl-8 ortho G lgg-1 Y38C1AA.11 ortho G lgg-1 ATP synthase subunit alpha, mitochondrial ortho G lgg-1 ZK1248.10 ortho G lgg-1 lgg-1 ortho G lgg-1 rpl-31 ortho G lgg-1 Y73B6BL.33a ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants G5EC43 Q09490 - 14704431 - X 2 Q09490 - 14704431 - X 2 Q8MQ04 Q09490 two hybrid 14704431 direct interaction X 2 Q9NA30 Q09490 two hybrid 14704431 direct interaction X 2 G5EG83 Q09490 two hybrid 14704431 physical association X 2 Q9NA30 Q09490 two hybrid 14704431 physical association X 2 Q9U389 Q09490 two hybrid pooling approach 19123269 physical association X 2 Q9U389 Q09490 two hybrid array 19123269 physical association X 2 P34296 Q09490 two hybrid pooling approach 19123269 physical association X 2 P34296 Q09490 two hybrid array 19123269 physical association X 2 Q8MQ04 Q09490 two hybrid pooling approach 14704431 physical association X 2 Q18192 Q09490 two hybrid pooling approach 19123269 physical association X 2 Q18192 Q09490 two hybrid array 19123269 physical association X 2 Q09490 G5EC37 confocal microscopy 19167332 colocalization X 2 Q09490 G5EC37 anti tag coimmunoprecipitation 19167332 physical association X 2 Q09490 G5EC37 pull down 19167332 physical association X 2 Q09490 Q18239 two hybrid pooling approach 21110867 physical association X 2 Q9NA30 Q09490 two hybrid pooling approach 14704431 physical association X 2 Q9NA30 Q09490 two hybrid pooling approach 19123269 physical association X 2 Q9NA30 Q09490 two hybrid array 19123269 physical association X 2 G5EFF2 Q09490 two hybrid pooling approach 19123269 physical association X 2 G5EFF2 Q09490 two hybrid array 19123269 physical association X 2 Q17740 Q09490 pull down 23619095 direct interaction X 2 Q17740 Q09490 pull down 23619095 direct interaction X 2 Q17740 Q09490 anti bait coimmunoprecipitation 23619095 physical association X 2 Q9U2F1 Q09490 two hybrid pooling approach 19123269 physical association X 2 Q9U2F1 Q09490 two hybrid array 19123269 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B lgg-1 atg-4.1 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 14704431,19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip)|(intact)|MI:0471(mint)|(intact) UniProt_29181|BIOGRID_25318|DIP_4790|UniProt_18331|MINT_3347|UniProt_20246 prey|prey|-|bait|prey|bait bait|bait|-|prey|bait|prey lgg-1 ain-1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 23619095 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_24488|UniProt_24489|UniProt_24487 prey|bait|bait unspecified role|prey|prey lgg-1 F20C5.6 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18328|UniProt_20245 bait|bait prey|prey lgg-1 zen-4 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_23441 prey bait lgg-1 dsh-2 MI:0398(two hybrid pooling approach) 21110867 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_21827 prey bait lgg-1 nhr-31 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_20199|UniProt_18284 bait|bait prey|prey lgg-1 Y46G5A.18 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_20243|UniProt_18330 bait|bait prey|prey lgg-1 R102.5 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_18329|UniProt_20244 bait|bait prey|prey lgg-1 sepa-1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19167332 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_19737|UniProt_19743|UniProt_19744 prey|neutral component|bait bait|neutral component|prey lgg-1 zen-4 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_1412|UniProt_31352 prey|prey bait|bait lgg-1 Q21493 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association) MI:0465(dip) DIP_2966 - - C06E1.1 lgg-1 MI:0398(two hybrid pooling approach)|MI:0398(two hybrid pooling approach) 19123269 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_19979|UniProt_18062 prey|prey bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q17740 Q09490 AIN-1 LGG-1 0.623 23619095 Q18239 Q09490 DSH-2 LGG-1 0.126 21110867 Q21493 Q09490 Q21493 LGG-1 0.033 14704431 Q8MQ04 Q09490 ZEN-4 LGG-1 0.126 14704431 Q9U2F1 Q09490 Q9U2F1 LGG-1 0.236 19123269 Q9U389 Q09490 Q9U389 LGG-1 0.236 19123269 Q18192 Q09490 NHR-31 LGG-1 0.236 19123269 Q09490 G5EFF2 LGG-1 G5EFF2 0.236 19123269 Q09490 P34296 LGG-1 P34296 0.236 19123269 Q09490 O17968 LGG-1 O17968 0.454 19167332 Q9NA30 Q09490 ATG-4.1 LGG-1 0.354 19123269,14704431 Q09490 G5EC37 LGG-1 SEPA-1 0.454 19167332