PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus R119.4 mett-10 14704431 biogrid,i2d,mint,intact exp G R119.4 pop-1 unassigned1274 intact exp R119.4 plk-1 18692475,unassigned701,14704431 biogrid,i2d,mint,intact,dip exp R119.4 eif-3.D 18692475,unassigned701 biogrid,intact exp G R119.4 M110.4a 18692475 mint exp G R119.4 R06A4.4a 18692475,unassigned701 biogrid,mint,intact exp Eyes absent homolog R119.4 14704431 biogrid,i2d,mint,intact,dip exp G F14F3.1a, Variable abnormal-3 R119.4 14704431 biogrid,intact exp G T04D1.3d R119.4 23549480 intact exp G R119.4 W04D2.1a 18692475,unassigned701,14704431 biogrid,i2d,mint,intact,dip exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q23158 O61708 - 14704431 - X 2 O61708 Q09357 - 14704431 - X 2 O61708 - 14704431 - X 2 P34331 O61708 - 14704431 - X 2 O61708 Q564S5 - 14704431 - X 2 O61708 P34331-2 two hybrid 18692475 direct interaction X 2 O61708 O62333 two hybrid 18692475 direct interaction X 2 O61708 P34331-2 two hybrid 14704431 direct interaction X 2 O61708 Q09357 two hybrid 14704431 direct interaction X 2 P30642 O61708 two hybrid 18692475 direct interaction X 2 O61708 Q9XVU8 two hybrid 18692475 direct interaction X 2 O61708 Q564S5 two hybrid 14704431 direct interaction X 2 O61708 G5EE71 two hybrid 14704431 direct interaction X 2 O61708 Q9XVU8 two hybrid 14704431 direct interaction X 2 Q23158 O61708 two hybrid 14704431 physical association X 2 O61708 P34331-2 two hybrid 14704431 physical association X 2 O61708 Q09357 two hybrid 14704431 physical association X 2 O61708 Q564S5 two hybrid 14704431 physical association X 2 O17670 O61708 two hybrid pooling approach 14704431 physical association X 2 Q23158 O61708 two hybrid pooling approach 14704431 physical association X 2 O61708 Q09357 two hybrid pooling approach 14704431 physical association X 2 O61708 A5A8Q9 two hybrid 23549480 physical association X 2 O61708 O62333 two hybrid - physical association X 2 O61708 P34331-2 two hybrid - physical association X 2 P30642 O61708 two hybrid - physical association X 2 P34331 O61708 two hybrid pooling approach 14704431 physical association X 2 O61708 G5EDS1 two hybrid pooling approach 14704431 physical association X 2 O61708 Q9XVU8 two hybrid - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B pqn-59 plk-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704431,18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0465(dip)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(biogrid)|(biogrid) MINT_4095|MINT_4100|MINT_4101|MINT_4097|MINT_4096|MINT_4104|MINT_4108|MINT_4105|MINT_4109|MINT_4102|DIP_1344|MINT_4106|MINT_4107|MINT_4103|UniProt_29725|MINT_6891|UniProt_24905|BIOGRID_28948|BIOGRID_21566 prey|prey|prey|prey|prey|prey|prey|prey|prey|prey|-|prey|prey|prey|prey|prey|prey|prey|prey null|null|null|null|null|null|null|null|null|null|-|null|null|null|bait|bait|null|bait|bait eya-1 pqn-59 MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0465(dip) UniProt_30055|MINT_7275|DIP_1672 bait|bait|- prey|prey|- pqn-59 Q17359 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:0() MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip) MINT_259|DIP_1994 prey|- bait|- pqn-59 vab-3 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_30378|BIOGRID_22329 prey|prey bait|bait pqn-59 mett-10 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|MI:0471(mint)|(biogrid) DIP_4870|UniProt_29263|MINT_3434|BIOGRID_25399 -|prey|prey|prey -|bait|bait|bait pqn-59 unc-57 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23778 prey bait pqn-59 atn-1 MI:0018(two hybrid) pubmed:unassigned701 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24652 prey bait pqn-59 eif-3.D MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_29337|UniProt_24610 prey|prey bait|bait pqn-59 atn-1 MI:0398(two hybrid pooling approach)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0465(dip) MINT_2469|UniProt_28349|DIP_3960 prey|prey|- bait|bait|- pqn-59 imb-2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_5327|UniProt_24904|MINT_5328|MINT_5329|MINT_5326|MINT_5325|MINT_5324|MINT_5331|MINT_5330 prey|prey|prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait|bait|bait pqn-59 eya-1 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_21961 prey bait pqn-59 ifg-1 MI:0018(two hybrid) 18692475 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) MI:0471(mint) MINT_5265 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q09357 O61708 METT-10 PQN-59 0.155 14704431 Q10666 O61708 POP-1 PQN-59 0.183 26780296 O61708 G5EDS1 PQN-59 VAB-3 0.126 14704431 Q17359 O61708 Q17359 PQN-59 0.033 14704431 Q9XVU8 O61708 ATN-1 PQN-59 0.183 unassigned701 O61708 O17670 PQN-59 EYA-1 0.155 14704431 O62333 O61708 IMB-2 PQN-59 0.332 unassigned701,18692475 Q23158 O61708 ATN-1 PQN-59 0.309 18692475,14704431 P34331 O61708 PLK-1 PQN-59 0.436 unassigned701,18692475,14704431 P30642 O61708 EIF-3.D PQN-59 0.183 unassigned701 O61708 B1V8A0 PQN-59 UNC-57 {ECO:0000312|WORMBASE:T04D1.3D} 0.183 23549480 Q21531 O61708 IFG-1 PQN-59 0.183 18692475